Two New Cytotoxic Phenylallylflavanones from Mexican Propolis
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概要
- 論文の詳細を見る
Two new phenylallylflavanones, (2R,3R)-6-[1-(4′-hydroxy-3′-methoxyphenyl)prop-2-en-1-yl]pinobanksin (1) and (2R,3R)-6-[1-(4′-hydroxy-3′-methoxyphenyl)prop-2-en-1-yl]pinobanksin 3-acetate (2) were isolated from a methanolic extract of Mexican propolis. Their structures were elucidated with spectroscopic analysis. Both compounds (1, 2) exhibited preferential cytotoxic activity against PANC-1 human pancreatic cancer cells in a nutrient-deprived medium with the concentration at which 50% cells died preferentially in NDM (PC50) values of 17.9 μM and 9.1 μM, respectively.
著者
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AWALE Suresh
Institute of Natural Medicine, University of Toyama
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KADOTA Shigetoshi
Institute of Natural Medicine, University of Toyama
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Awale Suresh
Institute Of National Medicine Toyama Medical And Pharmaceutical University
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Li Feng
Institute of Natural Medicine, University of Toyama
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Tezuka Yasuhiro
Institute Of Natural Medicine Univeristy Of Toyama
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Kadota Shigetoshi
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
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Li Feng
Institut National De La Recherche Scientifique Inrs-sante Universite Du Quebec
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Tezuka Yasuhiro
Institute of Natural Medicine, University of Toyama
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He Yu-Min
Institute of Natural Medicine, University of Toyama
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