Neuroprotective Effects of Constituents of the Oriental Crude Drugs,Rhodiola sacra, R. sachalinensis and Tokaku-joki-to, against Beta-amyloid Toxicity, Oxidative Stress and Apoptosis
スポンサーリンク
概要
- 論文の詳細を見る
We tested the constituents of two Rhodiola plants, Rhodiola sacra S. H. Fu and R. sachalinensis A. BOR, and an Oriental crude drug, Tokaku-joki-to, for their neuroprotective effects. Of the 58 compounds tested, six had considerable protective effects against beta-amyloid-induced death of B103 neuronal cells in vitro. These six compounds also showed protective effects against staurosporine-induced cell death, and two of the six compounds protected neurons from H_2O_2-induced cell death. These results suggest that some of the tested compounds protect neurons from beta-amyloid toxicity based on antiapoptotic and antioxidative activity.
- 公益社団法人日本薬学会の論文
- 2002-08-01
著者
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Kadota Shigetoshi
富山大学和漢医薬学総合研究所 化学応用分野
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Kadota S
Institute Of Natural Medicine University Of Toyama
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Kadota Shigetoshi
インドネシア
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門田 重利
Institute Of Natural Medicine University Of Toyama
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Tezuka Yasuhiro
Institute Of Natural Medicine Univeristy Of Toyama
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Fan Wenzhe
Institute Of National Medicine Toyama Medical And Pharmaceutical University
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Kadota Shigetoshi
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
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Kalauni S
Institute Of Natural Medicine University Of Toyama
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Kadota S
Toyama Medical And Pharamaceutical Univ. Toyama Jpn
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Nishijo H
System Emotional Science Graduate School Of Medicine Toyama Medical And Pharmaceutical University
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Nishijo Hisao
Faculty Of Medicine Department Of Physiology Toyama Medical And Pharmaceutical University
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Jung Min
Institute For Medical Sciences Ajou University School Of Medicine
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MOOK-JUNG Inhee
Brain Disease Research Center, Ajou University School of Medicine
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KIM Hee
Brain Disease Research Center, Ajou University School of Medicine
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Mook-jung Inhee
Brain Disease Research Center Ajou University School Of Medicine
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Kim Hee
Brain Disease Research Center Ajou University School Of Medicine
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手塚 康弘
Institute Of Natural Medicine University Of Toyama
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門田 重利
Institute of Natural Medicine, University of Toyama
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