Antioxidative Effects of Phenylethanoids from Cistanche deserticola
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概要
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The acetone-H_2O (9 : 1) extract from the stem of Cistanche deserticola showed a strong free radical scavenging activity. Nine major phenylethanoid compounds were isolated from this extract. They were identified by NMR as acteoside, isoacteoside, 2'-acetylacteoside, tubuloside B, echinacoside, tubuloside A, syringalide A 3'-α-rhamno-pyranoside, cistanoside A and cistanoside F. All of these compounds showed stronger free radical scavenging activities than α-tocopherol on 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical and xanthine/xanthine oxidase (XOD) generated superoxide anion radical (O^<&minusou;>_2). Among the nine compounds, isoacteoside and tubuloside B, whose caffeoyl moiety is at 6'-position of the glucose, showed an inhibitory effect on XOD. We further studied the effects of these phenylethanoids on the lipid peroxidation in rat liver microsomes induced by enzymatic and non-enzymatic methods. As expected, each of them exhibited significant inhibition on both ascorbic acid/Fe^<2+> and ADP/NADPH/Fe^<3+> induced lipid peroxidation in rat liver microsomes, which were more potent than α-tocopherol or caffeic acid.The antioxidative effect was found to be potentiated by an increase in the number of phenolic hydroxyl groups in the molecule.
- 公益社団法人日本薬学会の論文
- 1996-12-15
著者
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Tani Tadao
Research Laboratories For High Quality Of Life Sumitomo Metal Industries Ltd.
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Kadota S
Institute Of Natural Medicine University Of Toyama
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Namba Ttuneo
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
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Namba Tsuneo
富山医科薬科大学 生薬
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Namba Tsuneo
Research Institute For Wakan-yaku (traditional Sino-japanese Medicines) Toyama Medical And Pharmaceu
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Nagaoka Takema
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
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Nagaoka Takema
富山医科薬科大学和漢薬研究所
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Xiong Quanbo
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
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KADOTA Shigetoshi
Research Institute of Wakan-Yaku (Traditional Sino-Japanese Medicines), Toyama Medical and Pharmaceu
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XIONG Quanbo
Research Institute for Wakan-Yaku (Traditional Sino-Japanese Medicines), Toyama Medical and Pharmace
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Kadota Shigetoshi
Research Institute For Wakan-yaku (oriental Medicines) Toyama Medical And Pharmaceutical University
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Namba Tsuneo
Research Institute For Wakan-yaku (traditional Sino-japanese Medicine) Toyama Medical And Pharmaceut
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Namba Tsuneo
Research Institute For Wakan-yaku (oriental Medicine) Toyama Medical And Pharmaceutical University
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Tani Tadato
Research Laboratories for High Quality of Life, Sumitomo Metal Industries Ltd.,
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門田 重利
Institute of Natural Medicine, University of Toyama
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