Apocynins A-D : New Phenylpropanoid-substituted Flavan-3-ols Isolated from Leaves of Apocynum venetum (Luobuma-Ye)
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概要
- 論文の詳細を見る
Four new phenylpropanoid-substituted flavan-3-ols called apocynins A-D (1-4) have been isolated from the leaves of Apocynum venetum (Apocynaceae), together with two known phenylpropanoid-substituted flavan-3-ols, catechin-[8,7-e]-4α-(3,4-dihydroxyphenyl)-dihydro-2(3H)-pyranone (5) and cinchonain I1 (6), and four known flavan-3-ols, (-)-epicatechin, (+)-catechin, (-)epigallocatechin, and (+)-gallocatechin. Their structures were elucidated on the basis of spectral analysis, including 2D NMR and CD spectra. They showed hepatoprotective activity against D-galactosamine (D-GaIN)/tumor necrosis factor-α(TNF-α)-induced cell death in primary cultured mouse hepatocytes.
- 公益社団法人日本薬学会の論文
- 1999-07-15
著者
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KADOTA Shigetoshi
Institute of Natural Medicine, University of Toyama
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TEZUKA Yasuhiro
Institute of Natural Medicine, Toyama Medical and Pharmaceutical University
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Kadota S
富山大学和漢医薬学総合研究所
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KALAUNI Surya
Institute of Natural Medicine, University of Toyama
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XIONG Quanbo
Institute of Natural Medicine, Toyama Medical and Pharmaceutical University
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Kadota S
Institute Of Natural Medicine University Of Toyama
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Namba Ttuneo
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
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Namba Tsuneo
富山医科薬科大学 生薬
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Nagaoka Takema
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
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Nagaoka Takema
富山医科薬科大学和漢薬研究所
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HATTORI Masao
Institute of Natural Medicine, University of Toyama
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Xiong Quanbo
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
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Hattori Masao
Research Institute For Wakan-yaku (traditional Sino-japanese Medicines) Toyama Medical And Pharmaceu
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Hattori M
Research Institute For Wakan-yaku Toyama Medical And Pharmaceutical University
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Hattori Masao
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
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Tezuka Yasuhiro
Institute Of Natural Medicine Univeristy Of Toyama
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Namba Tsuneo
Institute Of Natural Medical Toyama Medicine And Pharmaceutical University
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FAN Wenzhe
Institute of Natural Medicine, Toyama Medical and Pharmaceutical University
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Fan Wenzhe
Institute Of National Medicine Toyama Medical And Pharmaceutical University
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Kadota Shigetoshi
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
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Hattori Masao
Institute Of Natural Medicine Faculty Of Pharmaceutical Sciences
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門田 重利
Institute of Natural Medicine, University of Toyama
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