Antimalarial Activity of Cassane- and Norcassane-Type Diterpenes from Caesalpinia crista and Their Structure-Activity Relationship(Pharmacology)

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概要

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• Malaria is one of the most life-threatening infectious diseases worldwide and claims the millions of peoples life each year. The appearance of drug-resistance Plasmodium falciparum has made the treatment of malaria increasingly problematic, and thus, it is a dire need to search the new alternatives of current drugs. In the present study, 44 cassane- and norcassane-type diterpenes isolated from Caesalpinia crista of Myanmar and Indonesia were evaluated for their antimalarial activity against the malaria parasite Plasmodium falciparum FCR-3/A2 clone in vitro. Most of the tested diterpenes displayed antimalarial activity, and norcaesalpinin E (28) showed the most potent activity with an IC_<50> value of 0.090μM, more potent than the clinically used drug chloroquine (IC_<50>, 0.29μM). Based on the observed results, a structure-activity relationship has been established.

• 社団法人日本薬学会の論文
• 2006-05-01

著者

• AWALE Suresh

  Institute of Natural Medicine, University of Toyama

• KADOTA Shigetoshi

  Institute of Natural Medicine, University of Toyama

• TEZUKA Yasuhiro

  Institute of Natural Medicine, Toyama Medical and Pharmaceutical University

• 門田 重利

  富山大学和漢医薬学総合研究所 化学応用部門

• Kadota S

  富山大学和漢医薬学総合研究所

• 門田 重利

  冨山大学和漢医薬学総合研究所

• 門田 重利

  富山大学和漢医薬学総合研究所資源開発部門化学応用分野

• 手塚 康弘

  富山大学和漢医薬学総合研究所化学応用分野

• Awale Suresh

  インドネシア

• Awale Suresh

  富山大学和漢医薬学総合研究所

• Awale Suresh

  Institute Of National Medicine Toyama Medical And Pharmaceutical University

• KALAUNI Surya

  Institute of Natural Medicine, University of Toyama

• SYAFRUDDIN Din

  Eijkman Institute for Molecular Biology

• ASIH Puji

  Eijkman Institute for Molecular Biology

• LINN Thein

  Department of Traditional Medicine, Ministry of Health, Union of Myanmar

• BANSKOTA Arjun

  Institute of Natural Medicine, University of Toyama

• LINN Thein

  Institute of Natural Medicine, University of Toyama

• Banskota A

  Institute Of Natural Medicine University Of Toyama

• Banskota Arjun

  富山医科薬科大学和漢薬研究所

• Banskota Arjun

  Institute Of National Medicine Toyama Medical And Pharmaceutical University

• Kadota Shigetoshi

  Institute Of Natural Medicine University Of Toyama

• Kadota Shigetoshi

  富山大学和漢医薬学総合研究所 化学応用分野

• Kadota S

  Institute Of Natural Medicine University Of Toyama

• Kadota Shigetoshi

  Univ. Toyama Toyama Jpn

• Kadota Shigetoshi

  インドネシア

• Awale Suresh

  Institute Of Natural Medicine Toyama Medical And Pharmaceutical University

• Banskota A

  富山医科薬科大学和漢薬研究所化学応用部門

• Banskota Arjun

  Department Of Natural Products Chemistry Institute Of Natural Medicine Toyama Medical And Pharmaceut

• 門田 重利

  Institute Of Natural Medicine University Of Toyama

• Tezuka Yasuhiro

  Univ. Toyama Toyama Jpn

• Tezuka Yasuhiro

  Institute Of Natural Medicine Univeristy Of Toyama

• Tezuka Yasuhiro

  Department Of Natural Products Chemistry Institute Of Natural Medicine Toyama Medical And Pharmaceut

• Tezuka Y

  Department Of Natural Products Chemistry Institute Of Natural Medicine Toyama Medical And Pharmaceut

• Kadota S

  Research Institute For Wakan-yaku(traditional Sino-japanese Medicines) Toyama Medical And Pharmaceut

• Kadota Shigetoshi

  Institute Of Natural Medicine Toyama Medical And Pharmaceutical University

• Linn Thein

  Department Of Traditional Medicine Ministry Of Health Union Of Myanmar

• Kalauni S

  Institute Of Natural Medicine University Of Toyama

• Kadota S

  Toyama Medical And Pharamaceutical Univ. Toyama Jpn

• 門田 重利

  Research Institute For Wakan-yaku (oriental Medicines) Toyama Medical And Pharmaceutical University

• Banskota Arjun

  Department Of Natural Products Chemistry Institute Of Natural Medicine Toyama Medical And Pharmaceut

• Tezuka Yasuhiro

  Department Of Natural Products Chemistry Institute Of Natural Medicine Toyama Medical And Pharmaceut

• 手塚 康弘

  Institute Of Natural Medicine University Of Toyama

• Banskota Arjun

  Institute For Marine Biosciences National Research Council

• 門田 重利

  Institute of Natural Medicine, University of Toyama

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