Cytotoxic Constituents of Propolis from Myanmar and Their Structure–Activity Relationship
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概要
- 論文の詳細を見る
Thirteen cycloartane-type tritepenes (1—13) and four prenylated flavanones (14—17) isolated from propolis collected in Myanmar, were evaluated for their cytotoxic activity against a panel of six different cancer cell lines; three murine cancer cell lines (colon 26-L5 carcinoma, B16-BL6 melanoma, and Lewis lung carcinoma) and three human cancer cell lines (lung A549 adenocarcinoma, cervix HeLa adenocarcinoma and HT-1080 fibrosarcoma). Among them, a cycloartane-type triterpene, 3α,27-dihydroxycycloart-24E-en-26-oic acid (3), showed the most potent cytotoxicity against B16-BL6 cells with an IC50 value of 5.91 μM, comparable to those of positive controls, doxorubicin (IC50, 5.66 μM) and 5-fluorouracil (IC50, 4.88 μM). In addition, (2S)-5,7-dihydroxy-4′-methoxy-8,3′-diprenylflavanone (14) exhibited strong cytotoxicity against all the tested cancer cell lines with the IC50 values ranging from 14.0 to 26.4 μM. Based on the observed results, the structure–activity relationships are discussed.
- 日本薬学会の論文
著者
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AWALE Suresh
Institute of Natural Medicine, University of Toyama
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KADOTA Shigetoshi
Institute of Natural Medicine, University of Toyama
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TEZUKA Yasuhiro
Institute of Natural Medicine, Toyama Medical and Pharmaceutical University
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Awale Suresh
インドネシア
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Awale Suresh
富山大学和漢医薬学総合研究所
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Awale Suresh
Institute Of National Medicine Toyama Medical And Pharmaceutical University
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Li Feng
Institute of Natural Medicine, University of Toyama
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Awale Suresh
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
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Li Feng
Institute Of Advanced Material Study Kyushu University
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Tezuka Yasuhiro
Institute Of Natural Medicine Univeristy Of Toyama
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Kadota Shigetoshi
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
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Li Feng
Institut National De La Recherche Scientifique Inrs-sante Universite Du Quebec
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Tezuka Yasuhiro
Institute of Natural Medicine, University of Toyama
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