Dipasperoside A, a Novel Pyridine Alkaloid-Coupled Iridoid Glucoside from the Roots of Dipsacus asper
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概要
- 論文の詳細を見る
A new pyridine alkaloid-coupled iridoid glucoside, dipasperoside A (1), and 20 known compounds (2–21) were isolated from a water extract of Dipsacus asper roots. Compound 1 possessed a unique structural feature with a nicotinic acid nucleus coupled through C-5 with C-7 of a secoiridoid/iridoid glucoside dimer, and esterified with a C-7 hydroxyl group of an iridoid glucoside monomer. All isolates were evaluated for their inhibitory activity against nitric oxide (NO) production in a lipopolysaccharide (LPS)-activated murine macrophage cell line, RAW264.7.
- 公益社団法人 日本薬学会の論文
著者
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Li Feng
Institute of Natural Medicine, University of Toyama
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SAIKI Ikuo
Institute of Natural Medicine, University of Toyama
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Tezuka Yasuhiro
Institute Of Natural Medicine Univeristy Of Toyama
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TANAKA Ken
Institute of Natural Medicine, University of Toyama
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Li Feng
Institut National De La Recherche Scientifique Inrs-sante Universite Du Quebec
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Saiki Ikuo
Institute Of Immunological Science Hokkaido University
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Tanaka Ken
Institute Of Natural Medicine University Of Toyama
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Watanabe Shiro
Institute of Natural Medicine, University of Toyama
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- Dipasperoside A, a Novel Pyridine Alkaloid-Coupled Iridoid Glucoside from the Roots of Dipsacus asper