Highly-Oxygenated Tsopimarane-Type Diterpenes from Orthosiphon stamineus of Indonesia and Their Nitric Oxide Inhibitory Activity
スポンサーリンク
概要
- 論文の詳細を見る
From the methanolic extract of Indonesian Orthosiphon stamineus, nine new highly-oxygenated isopimarane-type diterpenes [7-O-deacetylorthosiphol B (1), 6-hydroxyorthosiphol B (2), 3-0-deacetylorthosiphol I (3), 2-0-deacetyIorthosiphol J (4), siphonols A-E (5-9)1 have been isolated together with nine known diterpenes forthosiphols H (10), K (11), M (12) and N (13); staminols A (14) and B (15); neoorthosiphols A (16) and B (17); norstaminol A (18)|. Their structures were determined based on the spectroscopic data. The isolated diterpenes inhibited nitric oxide (NO) production in lipopolysaccharide (LPS)-activated macrophagc-like J774.1 cells. Compounds 4-7, 9, 10, 14, and 17 showed inhibitory activities more potent (IC_<50'>, 10.8-25.5μM) than a positive control N^G-monomethyl-L-arginine (L-NMMA; IC_<50'>, 26.0 μM).
- 社団法人日本薬学会の論文
- 2003-03-01
著者
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AWALE Suresh
Institute of Natural Medicine, University of Toyama
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KADOTA Shigetoshi
Institute of Natural Medicine, University of Toyama
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門田 重利
富山医科薬科大学和漢薬研究所化学応用部門
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Awale Suresh
インドネシア
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Awale Suresh
富山大学和漢医薬学総合研究所
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Awale Suresh
Institute Of National Medicine Toyama Medical And Pharmaceutical University
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BANSKOTA Arjun
Institute of Natural Medicine, University of Toyama
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TEZUKU Yasuhiro
Institute of Natural Medicine, Toyama Medical and Pharmaceutical University
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BANSKOTA Arjin
Institute of Natural Medicine, Toyama Medical and Pharmaceutical University
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ADNYANA I
Institute of Natural Medicine, Toyama Medical and Pharmaceutical University
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Banskota A
Institute Of Natural Medicine University Of Toyama
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Banskota Arjun
富山医科薬科大学和漢薬研究所
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Banskota Arjun
Institute Of National Medicine Toyama Medical And Pharmaceutical University
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Kadota Shigetoshi
富山大学和漢医薬学総合研究所 化学応用分野
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Kadota S
Institute Of Natural Medicine University Of Toyama
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Kadota Shigetoshi
インドネシア
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Awale Suresh
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
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Adnyana I
Toyama Medical And Pharmaceutical Univ. Toyama Jpn
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Adnyana I
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
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Banskota A
富山医科薬科大学和漢薬研究所化学応用部門
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Banskota Arjun
Department Of Natural Products Chemistry Institute Of Natural Medicine Toyama Medical And Pharmaceut
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門田 重利
Institute Of Natural Medicine University Of Toyama
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Tezuka Yasuhiro
Institute Of Natural Medicine Univeristy Of Toyama
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Kadota Shigetoshi
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
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Kalauni S
Institute Of Natural Medicine University Of Toyama
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Kadota S
Toyama Medical And Pharamaceutical Univ. Toyama Jpn
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Banskota Arjun
Department Of Natural Products Chemistry Institute Of Natural Medicine Toyama Medical And Pharmaceut
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手塚 康弘
Institute Of Natural Medicine University Of Toyama
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Banskota Arjun
Institute For Marine Biosciences National Research Council
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門田 重利
Institute of Natural Medicine, University of Toyama
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