Inhibition of NO Production by Highly-Oxygenated Diterpenes of Orthosiphon stamineus and Their Structure-Activity Relationship
スポンサーリンク
概要
- 論文の詳細を見る
Nitric oxide (NO) has been implemented in various pathological processes. In the present study, 47 highlyoxygenated isopimarane-type and novel carbon framework staminane-type diterpenes isolated from Orthosiphon stamineus of Indonesia, Okinawa, Myanmar and Vietnam were evaluated for their inhibitory activity in NO production by lipopolysaccharide (LPS)-activated macrophage-like J774.I cells. All the isolated diterpenes showed concentration-dependent inhibition of NO production in LPS-activated macrophage-like J774.1 cells, and based on the results, their structure-activity relationshis were established.
- 社団法人日本薬学会の論文
- 2003-04-01
著者
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AWALE Suresh
Institute of Natural Medicine, University of Toyama
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KADOTA Shigetoshi
Institute of Natural Medicine, University of Toyama
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TEZUKA Yasuhiro
Institute of Natural Medicine, Toyama Medical and Pharmaceutical University
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門田 重利
富山医科薬科大学和漢薬研究所化学応用部門
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Awale Suresh
インドネシア
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Awale Suresh
富山大学和漢医薬学総合研究所
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Awale Suresh
Institute Of National Medicine Toyama Medical And Pharmaceutical University
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BANSKOTA Arjun
Institute of Natural Medicine, University of Toyama
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Banskota A
Institute Of Natural Medicine University Of Toyama
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Banskota Arjun
富山医科薬科大学和漢薬研究所
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Banskota Arjun
Institute Of National Medicine Toyama Medical And Pharmaceutical University
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Kadota Shigetoshi
富山大学和漢医薬学総合研究所 化学応用分野
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Kadota S
Institute Of Natural Medicine University Of Toyama
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Kadota Shigetoshi
インドネシア
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Awale Suresh
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
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Banskota A
富山医科薬科大学和漢薬研究所化学応用部門
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Banskota Arjun
Department Of Natural Products Chemistry Institute Of Natural Medicine Toyama Medical And Pharmaceut
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門田 重利
Institute Of Natural Medicine University Of Toyama
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Tezuka Yasuhiro
Institute Of Natural Medicine Univeristy Of Toyama
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Kadota Shigetoshi
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
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Kalauni S
Institute Of Natural Medicine University Of Toyama
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Kadota S
Toyama Medical And Pharamaceutical Univ. Toyama Jpn
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Banskota Arjun
Department Of Natural Products Chemistry Institute Of Natural Medicine Toyama Medical And Pharmaceut
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手塚 康弘
Institute Of Natural Medicine University Of Toyama
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Banskota Arjun
Institute For Marine Biosciences National Research Council
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門田 重利
Institute of Natural Medicine, University of Toyama
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