Hepatoportective Constituents of the Seeds of Combretum quadrangulare
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概要
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Hepatoprotective effect of MeOH, MeOH-H_2O (1 : 1) and H_2O extracts of Combretum quadrangulare seeds were examined on D-galactosamine (D-GalN)/tumor necrosis factor-α(TNF-α)-induced cell death in primary cultured mouse hepatocytes. The MeOH extract showed the strongest inhibitory effect on D-GalN/TNF-α-induced cell death (IC_<50>, 56.4μg/ml). Moreover, the MeOH extract also significantly lowered the serum glutamic pyruvic transaminase (sGPT) level on D-GalN/lipopolysaccharide (LPS)-induced liver injury in mice. Bioguided separation of the MeOH extract led to the isolation of 38 compounds of various classes including triterpene glucosides, lignans and catechin derivatives. Among the isolated triterpene glucosides, lupane-type (1-3; IC_<50>, 63.1,59.8 and 76.2μM, respectively) and ursane-type (11,mixture of 12 and 14; IC_<50>, 30.2 and 34.6μM, respectively) compounds exhibited strong hepatoprotective activity. 1-O-Galloyl-6-O-(4-hydroxy-3,5-dimethoxy)benzoyl-β-D-glucose (26; IC_<50>, 7.2μM), methyl gallate (28; IC_<50>, 19.9μM), and (-)-epicatechin (31; IC_<50>, 71.2μM) also had a potent hepatoprotective effect on D-GalN/TNF-α-induced cell death in primary cultured mouse hepatocytes.
- 公益社団法人日本薬学会の論文
- 2000-11-01
著者
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KADOTA Shigetoshi
Institute of Natural Medicine, University of Toyama
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TEZUKA Yasuhiro
Institute of Natural Medicine, Toyama Medical and Pharmaceutical University
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KALAUNI Surya
Institute of Natural Medicine, University of Toyama
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BANSKOTA Arjun
Institute of Natural Medicine, University of Toyama
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KAWAKAMI Tsukasa
Institute of Natural Medicine, Toyama Medical and Pharmaceutical University
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ADNYANA I
Institute of Natural Medicine, Toyama Medical and Pharmaceutical University
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TRAN Kim
National University Ho Chi Minh City
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Banskota A
Institute Of Natural Medicine University Of Toyama
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Banskota Arjun
富山医科薬科大学和漢薬研究所
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Banskota Arjun
Institute Of National Medicine Toyama Medical And Pharmaceutical University
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Kadota S
Institute Of Natural Medicine University Of Toyama
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Tominaga Kazunari
Department Of Gastroenterology Osaka City University Graduate School Of Medicine
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Tran Kim
National University Hochiminh City
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Tominaga K
Osaka City Univ. Osaka Jpn
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Adnyana I
Toyama Medical And Pharmaceutical Univ. Toyama Jpn
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Adnyana I
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
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Tezuka Yasuhiro
Institute Of Natural Medicine Univeristy Of Toyama
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Torii K
Department Of Nuclear Medicine Graduate School Of Medicine Osaka City University
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Kadota Shigetoshi
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
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Kawakami Tsukasa
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
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手塚 康弘
Institute Of Natural Medicine University Of Toyama
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Banskota Arjun
Institute For Marine Biosciences National Research Council
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門田 重利
Institute of Natural Medicine, University of Toyama
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