Processing of Nux Vomica. IV. : A Comparison of Cytotoxicity of Nine Alkaloids from Processed Seeds of Strychnos nux-vomica on Tumor Cell Lines

概要

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Of the alkaloids isolated from the processed seeds of Strychnos nux-vomica, isostrychnine N-oxide and isobrucine N-oxide showed the most potent cytotoxicity to the tumor cell lines of K562, HeLa and HEP-2. The IC_<50> values of the former were 9.0 and 9.7 μM. against HeLa and K562, respectively, and that of the latter was 4.3 μm against HEP-2. These values were lower than those of the major alkaloids, strychnine and brucine. Since these compounds were formed by N-oxidation and/or ring-opening reaction of strychnos alkaloids during the processings, such as parching in a sand bath or frying in oil, both of these processing methods may be appropriate when nux vomica is to be used for possible treatment of cancer in traditional Chinese medicine.
日本生薬学会の論文
1995-03-20