Hepatoprotective Principles of Swertia japonica MAKINO on D-Galactosamine/Lipopolysaccharide-Induced Liver Injury in Mice
スポンサーリンク
概要
- 論文の詳細を見る
The n-BuOH extract of Swertia japonica showed a significant hepatoprotective effect on D-galactosamine(D-GalN)/lipopolysaccharide (LPS)-induced liver injury in mice. The activity-guided fractionation led to the isolation of a new tetrahydroxanthone derivative, tetrahydroswertianolin (1), as well as two known iridoids, gentiopicroside (2) and sweroside (3). Their structures were elucidated by spectroscopic methods and chemical reactions. Of the three compounds, 2 and 3 possessed mild hepatoprotective activity at a dose range of 25-50 mg/kg, whereas, 1 exhibited potent activity in a dose-dependent manner. The hepatoprotective effect of tetrahydroswertianolin (1) was stronger than that of glycyrrhizin which was used as a positive control.
- 公益社団法人日本薬学会の論文
- 1997-11-15
著者
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Kadota S
富山大学和漢医薬学総合研究所
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Kadota S
Institute Of Natural Medicine University Of Toyama
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Hase Koji
富山医科薬科大学和漢薬研究所
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Nanba T
Toyama Medical And Pharmaceutical Univ. Toyama Jpn
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Namba Ttuneo
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
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Namba Tsuneo
富山医科薬科大学 生薬
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Namba Tsuneo
Research Institute For Wakan-yaku (traditional Sino-japanese Medicines) Toyama Medical And Pharmaceu
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Nagaoka Takema
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
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Nagaoka Takema
富山医科薬科大学和漢薬研究所
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Li J
Research Institute For Wakan-yaku (traditional Sino-japanese Medicines) Toyama Medical And Pharmaceu
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Basnet Purusotam
Research Institute For Wakan-yaku (traditional Sino-japanese Medicines) Toyama Medical And Pharmaceu
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Hase Koji
Research Institute For Wakan-yaku (traditional Sino-japanese Medicines) Toyama Medical And Pharmaceu
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Xiong Quanbo
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
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KADOTA Shigetoshi
Research Institute of Wakan-Yaku (Traditional Sino-Japanese Medicines), Toyama Medical and Pharmaceu
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LI Jianxin
Research Institute for Wakan-Yaku (Traditional Sino-Japanese Medicines)
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XIONG Quanbo
Research Institute for Wakan-Yaku (Traditional Sino-Japanese Medicines), Toyama Medical and Pharmace
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TAKAMURA Shuichi
Health Science Laboratories, Yamanouchi Pharmaceutical Co., Ltd.,
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NAMBA Ttuneo
Research Institute for Wakan-Yaku (Traditional Sino-Japanese Medicines), Toyama Medical and Pharmace
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Basnet Purusotam
富山医科薬科大学和漢薬研究所
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Basnet Purusotam
Research Center For Ethnomedicines Institute Of Natural Medicine Toyama Medical And Pharmaceutical U
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Kadota Shigetoshi
Research Institute For Wakan-yaku (oriental Medicines) Toyama Medical And Pharmaceutical University
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Li Jianxin
Research Institute For Wakan-yaku (traditional Sino-japanese Medicines) Toyama Medical And Pharmaceu
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Takamura Shuichi
Faculty Of Medicine Toyama Medical And Pharmaceutical University
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Basnet P
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
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Takamura S
Graduate School Of Engineering Nagoya University
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Li Jianxin
Research Institute For Wakan-yaku (traditional Sino-japanese Medicines) Toyama Medical And Pharmaceu
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Hase Koji
Research Institute For Wakan-yaku (traditional Sino-japanese Medicines) Toyama Medical And Pharmaceu
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門田 重利
Institute of Natural Medicine, University of Toyama
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