Mechanism-Based Inhibition of CYP3A4 by Constituents of Zingiber aromaticum(Pharmacognosy)

スポンサーリンク

概要

• 論文の詳細を見る

• Sixteen compounds isolated from Zingiber aromaticum and showing concentration-dependent inhibition with IC_<50> values less than 100 μM, were analyzed for their possibility of time-, concentration-, and NADPH-de-pendent inhibition of CYP3A4 and four were analyzed for CYP2D6. All seven kaempferol glycosides and two kaempferol derivatives (4, 5, 8-14) appear to be the mechanism-based inhibitors of CYP3A4 enzyme in which the inhibition is irreversible and driven by the catalytic process. The other compounds showed no NADPH-dependent inhibition or reversible inhibition, and thus do not appear to be mechanism-based inhibitors. K_I values for compounds 4, 5, 8-14 were in the range of 2.21-27.01μM, whereas the k_<inact> values were 0.23-0.65 min^<-1>. Kaempferol-3-O-(2, 3, 4-tri-O-acetyl-α-L-rhamnopyranoside) (5) was found to be the most potent CYP3A4 inactivator with K_I and k_<inact> values of 2.21 μM and 0.45 min^<-1>, respectively.

• 公益社団法人日本薬学会の論文
• 2005-03-01

著者

• 門田 重利

  富山大学和漢医薬学総合研究所 化学応用部門

• Kadota S

  富山大学和漢医薬学総合研究所

• 門田 重利

  冨山大学和漢医薬学総合研究所

• 門田 重利

  富山大学和漢医薬学総合研究所資源開発部門化学応用分野

• 手塚 康弘

  富山大学和漢医薬学総合研究所化学応用分野

• WATABE Tadashi

  Department of Molecular Toxicology, Nihon Pharmaceutical University

• TEZUKA Yasuhiro

  Department of Natural Products Chemistry, Institute of Natural Medicine,Toyama Medical and Pharmaceu

• KALAUNI Surya

  Institute of Natural Medicine, University of Toyama

• Kadota Shigetoshi

  Department of Natural Products Chemistry, Institute of Natural Medicine, Toyama Medical and Pharmace

• Kadota Shigetoshi

  Institute Of Natural Medicine University Of Toyama

• Kadota Shigetoshi

  富山大学和漢医薬学総合研究所 化学応用分野

• Kadota S

  Institute Of Natural Medicine University Of Toyama

• Kadota Shigetoshi

  Univ. Toyama Toyama Jpn

• Kadota Shigetoshi

  インドネシア

• Watabe Tadashi

  Department Of Drug Metabolism And Molecular Toxicology Tokyo University Of Pharmacy And Life Science

• Watabe T

  Institute Of Natural Medicine Toyama Medical And Pharmaceutical University

• Usia T

  Toyama Medical And Pharmaceutical Univ. Toyama Jpn

• 門田 重利

  Institute Of Natural Medicine University Of Toyama

• Tezuka Yasuhiro

  Univ. Toyama Toyama Jpn

• Tezuka Yasuhiro

  Department Of Natural Products Chemistry Institute Of Natural Medicine Toyama Medical And Pharmaceut

• Tezuka Y

  Department Of Natural Products Chemistry Institute Of Natural Medicine Toyama Medical And Pharmaceut

• USIA Tepy

  Department of Natural Products Chemistry, Institute of Natural Medicine, Toyama Medical and Pharmace

• Kadota S

  Research Institute For Wakan-yaku(traditional Sino-japanese Medicines) Toyama Medical And Pharmaceut

• Kalauni S

  Institute Of Natural Medicine University Of Toyama

• Kadota S

  Toyama Medical And Pharamaceutical Univ. Toyama Jpn

• 門田 重利

  Research Institute For Wakan-yaku (oriental Medicines) Toyama Medical And Pharmaceutical University

• Usia Tepy

  Department Of Natural Products Chemistry Institute Of Natural Medicine Toyama Medical And Pharmaceut

• Tezuka Yasuhiro

  Department Of Natural Products Chemistry Institute Of Natural Medicine Toyama Medical And Pharmaceut

• Tezuka Yasuhiro

  Department Of General Thoracic Surgery Jichi Medical University And Saitama Medical Center

• Watabe Tadashi

  Department Of Drug Metabolism And Molecular Toxicology School Of Pharmacy Tokyo University Of Pharma

• 手塚 康弘

  Institute Of Natural Medicine University Of Toyama

• Watabe Tadashi

  Department of Natural Products Chemistry, Institute of Natural Medicine, Toyama Medical and Pharmaceutical University

• 門田 重利

  Institute of Natural Medicine, University of Toyama

関連論文

• Investigation on traditional medicine at Phu Quoc Island and Ninh Thuan Province in Vietnam
• Hypouricemic Effects of Acacetin and 4,5-O-Dicaffeoylquinic Acid Methyl Ester on Serum Uric Acid Levels in Potassium Oxonate-Pretreated Rats(Pharmacology)
• Xanthine Oxidase Inhibitors from the Heartwood of Vietnamese Caesalpinia sappan
• P-27 ミャンマーの薬用植物Dant-da-ku-niの化学成分と種々の癌細胞に対する細胞増殖抑制活性(腫瘍,一般演題ポスター,第24回和漢医薬学会大会 和漢薬の複雑さ-経験知と科学知-)
• 化学応用分野(資源開発部門,各部門・附属センターの活動と業績)
• 化学応用分野(各部門・附属センターの活動と業績)
• プロポリス成分CAPEおよびその類縁体の癌転移抑制活性に関する研究
• K-082(31) 五味子 (Schisandrae fructus) に含まれるチトクロム P450 3A4 阻害成分の同定
• In vivo Antiosteoporotic Effects of Dioscorea spongiosa and Its Constituent, Methyl protodioscin
• Hepatoprotective effects of the major lignans isolated from the wood of Taxus yunnanensis
• P-35 人参トリオール系サポニン代謝物の脂肪酸抱合物による抗腫瘍効果の発現
• J-3 プロポリス成分 CAPE 及びその類縁体による癌転移の抑制
• Traditional medicine of Madura island in Indonesia
• Panduratins D-I, Novel Secondary Metabolites from Rhizomes of Boesenbergia pandurata
• New prenylated flavones from Artocarpus champeden, and their antimalarial activity in vitro
• Constituents of Boesenbergia pandurata and Their cytotoxicity against PANC-1 Cells under Nutrient Deprived Condition(The 24th Annual Meeting of Medical and Pharmaceutical Society for WAKAN-YAKU)
• The healing art of traditional medicines in Myanmar
• Antimalarial Activity of Cassane- and Norcassane-Type Diterpenes from Caesalpinia crista and Their Structure-Activity Relationship(Pharmacology)
• Constituents of Caesalpinia crista from Indonesia
• Methyl Migrated Cassane-Type Furanoditerpenes of Caesalpinia crista from Myanmar
• Nitric Oxide (NO) Production Inhibitory Constituents of Tabebuia avellanedae from Brazil
• New Cassane-Type Diterpenes of Caesalpinia crista from Myanmar
• Constituents of the Leaves of Woodfordia fruticosa KURZ. I : Isolation, Structure, and Proton and Carbon-13 Nuclear Magnetic Resonance Signal Assignments of Woodfruticosin (Woodfordin C), an Inhibitor of Deoxyribonucleic Acid Topoisomerase II
• Studies on the Constituents of Medicinal and Related Plants in Sri Lanka. IV. Isolation and Structure Determination of Hyperenone-B, Mysorenone-B, and Mysorenone-C from Hypericum mysorense HEYNE and Synthesis of Hyperenone-A and -B
• Studies on the Constituents of Medicinal and Related Plants in Sri Lanka. II. Isolation and Structures of New γ-Pyrone and Related Compounds from Hypericum mysorense HEYNE
• ODOROUS METABOLITES OF AN ACELLULAR SLIME MOLD, PHYSARUM POLYCEPHALUM SCHW., AND A BASIDIOMYCETE, PHALLUS IMPUDICUS PERS.
• ISOLATION AND STRUCTURE OF MAGNOSALIN AND MAGNOSHININ, NEW NEOLIGNANS FROM MAGNOLIA SALICIFORIA MAXIM
• P-33 痒みモデルマウスを用いた漢方方剤の抗そう痒作用の検討
• 30C-13 紅景天(Rhodiola sacra S. H. Fu の地下部)のプロリルエンドペプチダーゼ阻害活性成分に関する研究
• 31A-12 伝統薬物による抗骨粗鬆活性成分の研究 (III) : 接骨木 Sambucus sieboldiana B_ex G_. (茎)と漢方方剤について
• 31A-11 牛膝の抗骨粗鬆活性に関する研究
• 30D-02 マクロファージからの NO 産生を抑制する生薬の探索
• 30A-08 マウス結腸癌実験的肝転移モデルにおける青〓子の転移抑制効果
• S-2 ススキ花穂による実験的アトピー性皮膚炎に及ぼす効果
• Five New C-Methyl Flavonoids, the Potent Aldose Reductase Inhibitors from Matteuccia orientalis TREV.
• I-A-15 伝統薬物による抗骨粗鬆活性成分の研究 : 升麻の活性成分について
• THREE NOVEL DIARYLHEPTANOIDS, CALYXIN A, CALYXIN B, AND 3-EPI-CALYXIN B FROM A CHINESE CRUDE DRUG "YUNNAN CAO KOU" (ALPINIA BLEPHAROCALYX K. SCHUM.)
• Enzymatic Sulfation of Glycosides and Their Corresponding Aglycones by Arylsulfate Sulfotransferase from a Human Intestinal Bacterium
• MATTEUORIENATE A AND B, TWO NEW AND POTENT ALDOSE REDUCTASE INHIBITORS FROM MATTEUCCIA ORIENTALIS (HOOK.) TREV.
• Enzymatic Sulfation of Polyphenols Related to Tannins by Arylsulfotransferase
• モルモット摘出回腸標本におけるステビア発酵エキスの抗histamine作用
• 伝統薬物を用いた抗ウイルス薬の開発
• 30C-04 生薬を用いた浴湯剤に関する研究 (III) : 生薬成分の皮膚透過に対する中国産川〓の吸収促進効果
• 30A-02 ヘルペスウイルス (HSV) 感染症に有効な大根草エキスの抗 HSV 活性成分の同定とその作用機序の解析
• S-3 伝統医薬から抗ウイルス剤の開発
• Mechanism-Based Inactivation of Human Liver Microsomal CYP3A4 by Rutaecarpine and Limonin from Evodia Fruit Extract
• タキサス天然成分タキサン化合物による腫瘍細胞増殖抑制とApoptosis誘導
• 3P-1172 エチレンナノバブルの作成とその利用(第2報)(6a生物化学工学,一般講演,生物化学工学,伝統の技と先端科学技術の融合)
• Two New Quinochalcone Yellow Pigments from Carthamus tinctorius and Ca^ Antagonistic Activity of Tinctormine
• TINCTRMINE, A NOVEL Ca^ ANTAGONIST N-CONTAINING QUINOCHALCONE C-GLYCOSIDE FROM CARTHAMUS TINCTORIUS L.
• Constituents of the Roots of Boerhaavia diffusa L. III. Identification of Ca^ Channel Antagonistic Compound from the Methanol Extract
• Inhibitors of nitric oxide (NO) production in murine macrophage-like J774.1 cells from Brazilian propolis
• Constituents of the Roots of Cynanchum bungei DECNE.Isolation and Structures of Four New Glucosides, Bunngeiside-A, -B, -C, and -D
• Inhibitory effect of Kampo medicines on bone resorption in vitro and preventive effect on bone loss in vivo
• 化学応用分野(資源開発部門,各部門・附属センターの活動と業績)
• A field survey of agarwood in Indonesia
• II-B-12 老化促進モデルマウスの空間認知機能障害に対する丹参成分 lithospermate B の作用
• II-A-8 空間認知機能障害に対する丹参の改善作用 : 老化促進モデルマウスでの検討
• Studies on the Neutral Constituents of Pachysandra terminalis SIEB. et ZUCC. VIII. Methyl Migration in the Dehydration Reaction of Pachysonol and Pachysandiol-B Derivatives
• An amazing cow's urine therapy practice in Myanmar (News Letter)
• Field survey of agarwood cultivation at Phu Quoc Island in Vietnam
• Investigation on traditional medicine in Myanmar and Vietnam
• S-5 紅豆杉の生物活性成分の探索
• A survey on agarwood in Vietnam
• Antioxidative and antihepatotoxic principles of Tuocha
• Synthesis and antihepatotoxic and antiproliferative activities of di- and tri-O-caffeoylquinic acid derivatives
• Anti-Helicobacter pylori activity of steroidal alkaloids obtained from three Veratrum plants
• 29B-03 LDL の酸化による内皮細胞傷害とマクロファージ泡沫化における羅布麻の関与
• 30B-08 羅布麻葉 (Apocynum venetum) エキスの血圧に及ぼす効果
• Constituents of the Seeds of Swietenia mahagoni JACQ. III. : Structures of Mahonin and Secomahoganin
• Constitutents of the Seeds of Swietenia mahagoni JACQ.II. : Structures of Swietemahonin A, B, C, D, E, F, and G and Swietemahonolide
• Constituents of the Seeds of Swietenia mahagoni JACQ. I. : Isolation, Structures, and ^1H- and ^C-Nuclear Magnetic Resonance Signal Assignments of New Tetranortriterpenoids Related to Swietenine and Swietenolide
• MAHONIN AND SECOMAHOGANIN, NEW TETRANORTRITERPENOIDS FROM SWIETENIA MAHOGANI (L.) JACQ
• Constituents of the Roots of Boerhaavia diffusa L. IV. Isolation and structure Determination of Boeravinones D, E, and F
• Studies on the Constituents of Orchidaceous Plants. IV. : Proton and Carbon-13 Signal Assignments of Cycloeucalenol-Type Triterpenes from Nervilia purpurea SCHLECHTER by Two-Dimensional Nuclear Magnetic Resonance Spectroscopy
• Studies on the Constituents of Medicinal and Related Plants in Sri Lanka. III. Novel Sesquilignans from Hedyotis lawsoniae
• EFFICIENT SYNTHESIS OF PAEONILACTONE-A AND -B FROM (-)-CARVONE
• 生薬を用いた浴湯剤に関する研究(第2報) : 黄連エキスの皮膚透過促進効果
• 生薬を用いた浴湯剤に関する研究 : 川〓エキスの経皮吸収促進効果
• I-B-5 生薬を用いた浴湯剤に関する研究 1 : 川〓エキスの経皮吸収および経皮吸収促進作用について
• Hypoglycemic effect of Aemotoxylon campechanum on streptozotocin (STZ)-induced diabetic rats
• Cytochrome P450 2D6 (CYP2D6) Inhibitory Constituents of Catharanthus roseus(Pharmacognosy)
• Mechanism-Based Inhibition of CYP3A4 by Constituents of Zingiber aromaticum(Pharmacognosy)
• Constituents of Zingiber aromaticum and Their CYP3A4 and CYP2D6 Inhibitory Activity
• A Combination of Soft-Shell Turtle Powder and Essential Oil of a Unicellular Chorophyte Prevents Bone Loss and Decreased Bone Strength in Ovariectomized Rats(Pharmacognosy)
• Constituents of Cimicifugae Rhizoma. I. Isolation and Characterization of Ten New Cycloartenol Triterpenes from Cimicifuga heracleifolia KOMAROV
• Studies on the Neutral Constitutents of Pachysandra terminalis SIEB. et ZUCC. XI. Occurrence of Pachysana-16,21-diene-3β, 28-diol and Pachysan-16-ene-3β, 28-diol, Novel Triterpene-diols with a New Skeleton Related to Friedelane
• 28E-05 羅布麻 (Apocynum venetum L.) 葉の肝臓保護作用及びその活性成分に関する研究
• I-B-8 南蛮毛の I 型アレルギー反応に対する作用
• Odorous Metabolites of Fungi, Chaetomium globosum KINZE ex FR. and Botrytis cinerea PERS. ex FR., and a Blue-green Alga, Phormidium tenue (MENEGHINI) GOMONT
• EFFECTIVE SEPARATION OF STEROL C-24 EPIMERS BY REVERSED-PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY
• 2'-Hydroxymatteucinol, a New C-Methyl Flavanone Derivative from Matteccia orientalis; Potent Hypoglycemic Activity in Streptozotocin (STZ)-Induced Diabetic Rat
• Studies on the Constituents of Medicinal and Related Plants in Sri Lanka. I. New Triterpenes from Hedyotis lawsoniae
• Two New 2-Arylbenzofuran Derivatives from Hypoglycemic Activity-Bearing Fractions of Morus insignis
• Palbinone, a Novel Terpenoid from Peaonia albiflora; Potent Inhibitory Activity on 3α-Hydroxysteroid Dehydrogenase
• DETHIO-TETRA (METHYLTHIO) CHETOMIN, A NEW ANTIMICROBIAL METABOLITE OF CHAETOMIUM GLOBOSUM KINZE EX FR. STRUCTURE AND PARTIAL SYNTHESIS FROM CHETOMIN
• Constituents of the Roots of Boerhaavia diffusa L. II. : Structure and Stereochemistry of a New Rotenoid, Boeravinone C
• Constituents of the Roots of Boerhaavia diffusa L. I. : Examination of Sterols and Structures of New Rotenoids, Boeravinones A and B
• STRUCTURE AND NMR SPECTRA OF BOERAVINONE C, A NEW ROTENOID ANALOGUE FROM ___- ___- LINN
• BOERAVINONE A AND B, NEW ROTENOID ANALOGUES FROM ___- ___- LINN

もっと見る 閉じる

スポンサーリンク