Conversion of aconitine lipoaconitine by human intestinal bacteria and their antinociceptive effects in mice
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概要
- 論文の詳細を見る
Aconitineはヒト腸内細菌とインキュベーションすることにより,lipoaconitine(LA)に変換された。Frit-FAB LC/MSやGC/MSによる分析結果から,このLAの脂肪酸組成は用いた菌種の脂肪酸組成と類似していることが明らかとなった。すなわち,Bacteroides fragilisから生成するLAの主な脂肪酸はanteiso-C15:0,n-C15:0,n-C16:0であり,Klebsiella pneumoniaeや糞便の細菌叢によって生成するものはn-C16:0であった。また,Clostridium butyricumからのLAはC18:1,C18:0,C16:1,C16:0であった。LAはまた,リン酸緩衝液中でaconitineと加熱処埋した細菌や細胞破砕後の沈殿物とのインキュベーションによっても生成した。Aconitineは0.1mg/kgの用量で侵害受容高感受性マウスにおける侵害受容閾値を増大させたが,8-O-oleoylbenzoylaconine(OBA)は3.0mg/kgの高用量で活性を示し,毒性も見られた。8-O-Palmitoylbenzoylaconine(PBA)は30mg/kgで活性を示した。これらの知見からORA,PBAは附子やそのアルカロイド(aconitine)の抗侵害受容作用に重要な役割を演じてはいないことが示唆された。
- 和漢医薬学会の論文
- 1999-04-30
著者
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Wang Hong
Department of Oriental Medicinal Material & Processing, College of Life Science, Kyung Hee Universit
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服部 征雄
富山大学和漢医薬学総合研究所
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服部 征雄
富山医科薬科大学和漢薬研究所
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MESELHY Meselhy
Institute of Natural Medicine, Faculty of Pharmaceutical Sciences and Pharmaceutical University
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NAKAMURA Norio
富山医科薬科大学和漢薬研究所
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Nanba T
Toyama Medical And Pharmaceutical Univ. Toyama Jpn
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Namba Ttuneo
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
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Namba Tsuneo
Research Institute For Wakan-yaku (traditional Sino-japanese Medicines) Toyama Medical And Pharmaceu
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Hattori Masao
Department Of Metabolic Engineering Institute Of Natural Medicine Toyama Medical And Pharmaceutical
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MESELHY Meselhy
Department of Metabolic Engineering, Institute of Natural Medicine, Toyama Medical and Pharmaceutica
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NAKAMURA Norio
Department of Metabolic Engineering, Institute of Natural Medicine, Toyama Medical and Pharmaceutica
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KAWATA Yukio
Development for Drug-resources, Research Institute for Wakan-Yaku
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MA Cho-mei
Departments of Cell-Resources Engineering, Research Institute for Wakan-Yaku
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NAMBA Tsuneo
Development for Drug-resources, Research Institute for Wakan-Yaku
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SATOH Kazuya
Department of Applied Pharmacology
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KURAISI Yasushi
Department of Applied Pharmacology
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Namba T
Development For Drug-resources Research Institute For Wakan-yaku
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Meselhy Meselhy
Departments Of Cell-resources Engineering Research Institute For Wakan-yaku
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Meselhy Meselhy
Department Of Cell-resources Engineering Institute Of Natural Medicine Toyama Medical And Pharmaceut
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Nakamura N
Toyama Medical And Pharmaceutical Univ. Toyama Jpn
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Ma Cho-mei
Departments Of Cell-resources Engineering Research Institute For Wakan-yaku
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Kawata Yukio
Development For Drug-resources Research Institute For Wakan-yaku
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Meselhy M
Institute Of Natural Medicine Facully Of Pharmaceutical Sciences And Pharmaceutical University
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服部 征雄
富山医科薬科大学
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Wang Hong
Department Of Applied Biology Faculty Of Textile Science And Technology Shinshu University
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Namba Tsuneo
富山医科薬科大学和漢薬研究所 資源開発部門
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Nakamura N
Departments Of Cell-resources Engineering Research Institute For Wakan-yaku
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Kuraishi Yasushi
Department Of Applide Biochemistry Research Institute For Wakan-yaku Toyama Toyama Medical And Pharm
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Nakamura Norio
Department Of Biology Yokohama City University
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Nakamura Norio
Institute Of Natural Medicine Facully Of Pharmaceutical Sciences And Pharmaceutical University
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Nakamura Norio
Institute Of Natural Medicine
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Nakamura Norio
Department Of Anatomy Gunma University School Of Medicine
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Wang Hong
Departments Of Cell-resources Engineering Research Institute For Wakan-yaku
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