Determination of novel nitrogen-containing metabolites after oral administration of swertiamarin to rats
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概要
- 論文の詳細を見る
Wistarラットを用いて伝統医療に用いられるスウェルチア植物の主成分であるswertiamarin(1)の代謝研究をおこなった。swertiamarin(1)を経口投与後,ラットの血漿を液体クロマトグラフィー/イオントラップマススペクトロメトリー法で分析し,新規代謝物(R)-gentianol(4a),(S)-gentianol(4b),及び既知代謝物gentianine(2)を同定した。これら全ては窒素を含む代謝物であり,代謝物の構造は,swertiamarin(1)から合成した標準化合物とのHPLCでの保持時間,MS,MS/MSスペクトルの直接比較により決定した。(S)-gentianol(4b)を,gentianine(2)から得たgentianone(3)の立体選択的還元反応により合成し,その絶対立体配置を新モッシャー法により確定した。
- 和漢医薬学会の論文
- 2008-05-30
著者
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服部 征雄
富山大学和漢医薬学総合研究所
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KAWASAKI Masashi
Faculty of Engineering,Toyama Prefectural University
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WANG Zhigang
Division of Metabolic Engineering, Institute of Natural Medicine, University of Toyama
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MA Chaomei
Division of Metabolic Engineering, Institute of Natural Medicine, University of Toyama
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TANG Shuhan
Division of Metabolic Engineering, Institute of Natural Medicine, University of Toyama
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KIDA Hiroaki
ALPS Pharmaceutical Ind. Co., Ltd.
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Ma Chaomei
Division Of Metabolic Engineering Institute Of Natural Medicine University Of Toyama
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Tang Shuhan
Division Of Metabolic Engineering Institute Of Natural Medicine University Of Toyama
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Wang Zhigang
Division Of Metabolic Engineering Institute Of Natural Medicine University Of Toyama
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TOYOOKA Naoki
Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama
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Toyooka Naoki
Graduate School Of Medicine And Pharmaceutical Sciences University Of Toyama
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Kawasaki Masashi
Faculty Of Engineering Toyama Prefectural University
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Kida Hiroaki
Alps Pharmaceutical Ind. Co. Ltd
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