Metabolism of Paeoniflorin and Related Compounds by Human Intestinal Bacteria
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概要
- 論文の詳細を見る
In the course of studies on the metabolism of active components of crude drugs by intestinal bacteria, paeoniflorin, oxypaeoniflorin, and benzoylpaeoniflorin isolated from the roots of Paeonia albiflora PALLAS (Paeoniaceae) were incubated with a human fecal suspension. Paeoniflorin, as well as oxypaeoniflorin and benzoylpaeoniflorin, was converted to three metabolites (paeonimetabolines I, II and III) by intestinal bacteria. The structure of the major metabolite (paeonimetaboline I) was elucidated by spectroscopic methods. Through screening of various strains of intestinal bacteria from human feces, Peptostreptococcus anaerobius was shown to have potent ability to transform paeoniflorin to paeonimetaboline I.
- 社団法人日本薬学会の論文
- 1985-09-25
著者
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清水 岑夫
Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University
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森田 直賢
Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University
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林 利光
Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University
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服部 征雄
富山医科薬科大学和漢薬研究所
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林 利光
富山医科薬科大学薬学部
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小橋 恭一
Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University
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服部 征雄
Research Institute for Wakan-Yaku, Toyama Medical and Pharmaceutical University
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徐 国鈞
China Pharmaceutical University
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難波 恒雄
Research Institute for Wakan-Yaku (Oriental Medicines), Toyama Medical and Pharmaceutical University
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舒 躍中
Research Institute for Wakan-Yaku Toyama Medical and Pharmaceutical University
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徐 国鈞
Nanking College of Pharmacy
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清水 岑夫
Faculty Of Pharmaceutical Science Toyama Medical And Pharmaceutical University
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清水 岑夫
富山医科薬科大学薬
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清水 岑夫
富山大学薬学部
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清水 岑夫
富山医科薬科大学和漢薬研究所
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清水 岑夫
Faculty Of Pharmaceutical Science
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森田 直賢
Department Of Medicinal Resources Faculty Of Pharmaceutical Sciences Toyama Medical & Pharmaceut
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舒 躍中
富山医科薬科大学和漢薬研究所資源開発部門
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Kobayashi K
Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University
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林 利光
富山医科薬科大学薬学部生薬学教室
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服部 征雄
Research Institute For Wakan-yaku (oriental Medicines) Toyama Medical And Pharmaceutical University
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難波 恒雄
Research Institute For Wakan-yaku (oriental Medicines) Toyama Medical And Pharmaceutical University
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林 利光
Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University
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