Effect of Depignentation for 3,4-di-O-Caffeoylquinic Acid Guided by Tyrosinase Inhibitory Activity from Conyza filaginoides
スポンサーリンク
概要
- 論文の詳細を見る
Examination of a water extract of Conyza filaginoides guided by tyrosinase inhibitory activity afforded twelve compounds including five phenylpropanoids, three flavonoids, two nucleic acids and two icarisides. Among them, four compounds, 3,4-di-O -caffeoylquinic acid 3, 4-O -caffeoylquinic acid 4, chlorogenic acid 5 and rutin 8 showed strong inhibitory activities with IC50s of 57.7, 393.7, 273.2 and 113.7 μM, respectively, and their inhibition modes were noncompetitive. The whitening effect of the most effective compound 3 was also examined, and it showed distinct depigmentation against UVB-irradiated skin of browm guinea pig (the depigmentation percentage was 30.8%).
- 日本油化学会の論文
- 2001-04-01
著者
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KALAUNI Surya
Institute of Natural Medicine, University of Toyama
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Kadota S
Institute Of Natural Medicine University Of Toyama
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TEZUKA Yasuhiro
Research Institute for Wakan-Yaku, Toyama Medical and Pharmaceutical University
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Tezuka Yasuhiro
Research Institute For Wakan-yaku (oriental Medicines) Toyama Medical And Pharmaceutical University
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下村 健次
御木本製薬
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KADOTA Shigetoshi
Research Institute of Wakan-Yaku (Traditional Sino-Japanese Medicines), Toyama Medical and Pharmaceu
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Kadota Shigetoshi
Research Institute For Wakan-yaku (oriental Medicines) Toyama Medical And Pharmaceutical University
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下村 健次
御木本製薬株式会社
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Ito Shiho
Research & Development Department Mikimoto Pharmaceutical Co. Ltd.
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Tada Takahiro
Research & Development Department Mikimoto Pharmaceutical Co. Ltd.
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Shimomura K
Department Of Materials Science And Engineering Iwate University
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SHIMOMURA Kenji
Research & Development Department, Mikimoto Pharmaceutical Co., Ltd.
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HATTORI Humihiro
Research & Development Department, Mikimoto Pharmaceutical Co., Ltd.
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Shimomura Kenji
Research & Development Department Mikimoto Pharmaceutical Co. Ltd.
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Shimomura Kenji
Research & Development Divesion Mikimoto Pharmaceutical Co. Ltd
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Hattori Humihiro
Research & Development Department Mikimoto Pharmaceutical Co. Ltd.
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下村 健次
御木本製薬(株)
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手塚 康弘
Institute Of Natural Medicine University Of Toyama
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門田 重利
Institute of Natural Medicine, University of Toyama
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