Processing of Nux Vomica. VII. Antinociceptive Effects of Crude Alkaloids from the Processed and Unprocessed Seeds of Strychnos nux-vomica in Mice
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概要
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We examined the antinociceptive effects of the crude alkaloid fractions (CAF) of nux vomica (the dried seeds of Strychnos nux-vomica L.) and the influences of various processing methods upon their antinociception in three analgesic tests in mice. In the tail-pressure test, the CAF (0.01-1 μg/kg, i.p.) of nux vomica that was unprocessed or treated with sand-, licorice-, oil- or vinegar and sand-processing showed clear antinociception. The CAF (1 μg/kg, i.p.) of vinegar-processed nux vomica showed antinociception, without effects at lower doses of 0.01 and 0.1 μg/kg and those treated with urine- or urine and sand-processing were without effects at doses of 0.01-1 μg/kg. Morphine (2 mg/kg, s.c.) showed short-lasting antinociception, without effects at a dose of 1 μg/kg. In the hot-plate test, the CAF (100 μg/kg, i.p.) of nux vomica having undergone sand-processing produced a significant antinociception, without effects at lower doses of 0.01 and 1 μg/kg. The CAF (0.01-100 μg/kg, i.p.) of nux vomica that was unprocessed or treated with oil- or vinegar and sand-processing and morphine (1 and 100 μg/kg, s.c.) were without effects. In the acetic acid-induced writhing test, the CAF (1 μg/kg, i.p.) of nux vomica that was treated with sand-processing significantly inhibited the writhing behavior, while those of nux vomica that was unprocessed or treated with oil- or vinegar and sand-processing and morphine were without effects at a dose of 1 μg/kg. The present results demonstrate the antinociceptive effects of the CAF of nux vomica and suggest that sand-processing is good for the analgesic potency of nux vomica. It is also suggested that the CAF of nux vomica has distinct antinociceptive potency, even after treatment with licorice-, oil-, vinegar and sand-processing.
- 公益社団法人日本薬学会の論文
- 1996-01-15
著者
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Kadota S
Institute Of Natural Medicine University Of Toyama
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Namba Ttuneo
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
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Namba Tsuneo
Research Institute For Wakan-yaku (traditional Sino-japanese Medicines) Toyama Medical And Pharmaceu
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Nagaoka Takema
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
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Hattori Masao
Research Institute For Wakan-yaku (traditional Sino-japanese Medicines) Toyama Medical And Pharmaceu
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Hattori Masao
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
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Namba T
Development For Drug-resources Research Institute For Wakan-yaku
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KADOTA Shigetoshi
Research Institute of Wakan-Yaku (Traditional Sino-Japanese Medicines), Toyama Medical and Pharmaceu
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CAI Baochang
Nanjing Traditional Chinese Medical and Pharmaceutical University
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NAGASAWA Tetsuro
Research Institute for Wakan-Yaku (Traditional Sino-Japanese Medicines), Toyama Medical and Pharmace
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KURAISHI Yasushi
Research Institute for Wakan-Yaku (Traditional Sino-Japanese Medicines), Toyama Medical and Pharmace
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Kuraishi Yasushi
Research Institute For Wakan-yaku (traditional Sino-japanese Medicines) Toyama Medical And Pharmaceu
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Kadota Shigetoshi
Research Institute For Wakan-yaku (oriental Medicines) Toyama Medical And Pharmaceutical University
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Nagasawa Tetsuro
Research Institute For Wakan-yaku (traditional Sino-japanese Medicines) Toyama Medical And Pharmaceu
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Namba Tsuneo
Research Institute For Wakan-yaku (traditional Sino-japanese Medicine) Toyama Medical And Pharmaceut
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Namba Tsuneo
Research Institute For Wakan-yaku (oriental Medicine) Toyama Medical And Pharmaceutical University
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HATTORI MASAO
Research Institute for Wakan-Yaku (Oriental Medicines)
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門田 重利
Institute of Natural Medicine, University of Toyama
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