Aodose Reductase Inhibitory Constituents of the Root of Salvia miltiorhiza BUNGE
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概要
- 論文の詳細を見る
The constituents of the MeOH extract of Salvia miltiorhiza BUNGE, which showed strong aldose reductase (AR) inhibitory activity, were examined, and two new abietane-type diterpenoids, danshenol A (1) and danshenol B (2), were isolated together with six known ones : dihydrotanshinone I (3), cryptotanshinone (4), tanshinone I (5), tanshinone IIA (6), (-)-danshexinkun A (7), and sugiol (8). Among them, 4,5,and 8 were weak AR inhibitors with IC_<50> from 4.80 to >10.0μM, while 1,2,3,6,and 7 were strong inhibitors (IC_<50> from 0.10 to 1.75μM). Danshenol A (1), the strongest inhibitor, had IC_<50> of 0.10μM which is comparable to that of epalrestat in clinical use.Moreover, from a consideration of IC_<50> and yield of each compound, it was concluded that tanshinone IIA (6) is the major active constituent of the MeOH extract and danshenol A (1) and (-)-danshexinkun A (7) are the minor ones.
- 公益社団法人日本薬学会の論文
- 1997-08-15
著者
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Kadota S
富山大学和漢医薬学総合研究所
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Kadota S
Institute Of Natural Medicine University Of Toyama
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TEZUKA Yasuhiro
Research Institute for Wakan-Yaku, Toyama Medical and Pharmaceutical University
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Namba Ttuneo
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
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Namba Tsuneo
富山医科薬科大学 生薬
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Namba Tsuneo
Research Institute For Wakan-yaku (traditional Sino-japanese Medicines) Toyama Medical And Pharmaceu
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Nagaoka Takema
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
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Nagaoka Takema
富山医科薬科大学和漢薬研究所
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Basnet Purusotam
Research Institute For Wakan-yaku (traditional Sino-japanese Medicines) Toyama Medical And Pharmaceu
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Tezuka Yasuhiro
Research Institute For Wakan-yaku (oriental Medicines) Toyama Medical And Pharmaceutical University
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KADOTA Shigetoshi
Research Institute of Wakan-Yaku (Traditional Sino-Japanese Medicines), Toyama Medical and Pharmaceu
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KASIMU Rena
Research Institute for Wakan-Yaku (Traditional Sino-Japanese Medicines), Toyama Medical and Pharmace
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Basnet Purusotam
富山医科薬科大学和漢薬研究所
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Basnet Purusotam
Research Center For Ethnomedicines Institute Of Natural Medicine Toyama Medical And Pharmaceutical U
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Kadota Shigetoshi
Research Institute For Wakan-yaku (oriental Medicines) Toyama Medical And Pharmaceutical University
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Kasimu Rena
Research Institute For Wakan-yaku (traditional Sino-japanese Medicines) Toyama Medical And Pharmaceu
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Basnet P
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
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Namba Tsuneo
Research Institute For Wakan-yaku (traditional Sino-japanese Medicine) Toyama Medical And Pharmaceut
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Namba Tsuneo
Research Institute For Wakan-yaku (oriental Medicine) Toyama Medical And Pharmaceutical University
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門田 重利
Institute of Natural Medicine, University of Toyama
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