Prolyl Endopeptidase Inhibitors from the Underground Part of Rhodiola sachalinensis
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概要
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The methanolic extract of the underground part of Rhodiola sachalinensis was found to show inhibitory activity on prolyl endopeptidase(PEP, EC.3.4.21.26), an enzyme that plays a role in the metabolism of proline-containing neuropeptidase which is recognized to be involved in learning and memory. From the MeOH extract, five new monoterpenoids named sachalinols A(24), B(25)and C(26)and sachalinosides A(23)and B(27)were isolated, together with twenty-two known compounds, gallic acid(1), trans-p-hydroxycinnamic acid(2), p-tyrosol(3), salidroside(4), 6"-O-galloylsalidroside(5), benzyl β-_D-glucopyranoside(6), 2-phenylethyl β-_D-glucopyranoside(7), trans-cinnamyl β-_D-glucopyranoside(8), rosarin(9), rhodiocyanoside A(10), lotaustralin(11), octyl β-_D-glucopyranoside(12), 1, 2, 3, 6-tetra-O-galloyl-β-_D-glucose(13), 1, 2, 3, 4, 6-penta-O-galloyl-β-_D-glucose(14), kaempferol(15), Kaempferon 3-O-β-_D-xylofuranosyl(1→2)-β-_D-glucopyranoside(16), kampferol 3-O-β-_D-glucopyranosyl(1→2)-β-_D-glucopyranoside(17), rhodionin(18), rhodiosin(19), (-)-epigallocatechin(20), 3-O-β-_D-galloylepigallocatechin-(4→8)-epigallocatechin 3-O-gallate(21)and rosiridin(22). Among these, nineteen compounds other than 3, 4 and 9 have been isolated for the first time from R.sachalinensis, and six(6, 8, 13, 16, 17, 20)are isolated from Rhodiola plants for the first time. Among them, six compounds(13, 14, 18, 19, 21, 22)showed noncompetitive inhibition against Flavobacterium PEP, with an IC_<50> of 0.025, 0.17, 22, 41, 0.44 and 84μ_M, respectively.
- 公益社団法人日本薬学会の論文
- 2001-04-01
著者
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KADOTA Shigetoshi
Institute of Natural Medicine, University of Toyama
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TEZUKA Yasuhiro
Institute of Natural Medicine, Toyama Medical and Pharmaceutical University
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KALAUNI Surya
Institute of Natural Medicine, University of Toyama
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Kadota S
Institute Of Natural Medicine University Of Toyama
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Ni Khin
Mandalay Art & Science University
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Tezuka Yasuhiro
Institute Of Natural Medicine Univeristy Of Toyama
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FAN Wenzhe
Institute of Natural Medicine, Toyama Medical and Pharmaceutical University
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Fan Wenzhe
Institute Of National Medicine Toyama Medical And Pharmaceutical University
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Kadota Shigetoshi
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
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手塚 康弘
Institute Of Natural Medicine University Of Toyama
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門田 重利
Institute of Natural Medicine, University of Toyama
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