Effects of Flavonoids and Alkaloids on Reverse Transcriptase
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概要
- 論文の詳細を見る
One hundred-ninety flavonoids and 75 alkaloids were studied for their inhibitory effects on the Avian Myeloblastosis Virus reverse transcriptase (AMV-RT) by using (rA)_n-p(dT)_<12-18> or (rC)_n-p(dG)_<12-18> as a template-primer. Of the flavonoids tested, 6-hydroxyluteolin (50), pedalitin (52), 6-hydroxykaempferol (109) and quercetagetin (129), were the most potent inhibitors with IC_<50>≦10 μM. Five other flavonoids, baicalein (19), baicalin methyl ester (23), scutellarein (33), myricetin (126) and gossypetin (130), gave IC_<50> between 35 and 200 μM. The kinetic studies on 50, 126 and 130 gave the inhibitory constants (K_i) of 10, 94 and 90 μM, respectively, with respect to the substrate and 5, 200 and 100 μM, respectively, with respect to the template-primer. Structurally different alkaloids such as isoquinoline, indol, steroidal, quinolizidine, pyrrolizidine, pyridine and imidazole alkaloids were also investigated for the activity and berberine type alkaloids were shown to have a strong inhibitory activity. Flavonoids or alkaloids that inhibited AMV-RT did not show any significant effect on DNA-polymerase I.
- 日本生薬学会の論文
- 1991-09-20
著者
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花岡 美代次
金沢大学薬学部
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Nagaoka Takema
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
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Hanaoka Miyoji
Faculty Of Pharmaceutical Sciences Kanazawa University
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Hattori Masao
Research Institute For Wakan-yaku (traditional Sino-japanese Medicines) Toyama Medical And Pharmaceu
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Miyaichi Y
北陸大学 薬学科生薬学
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Tomimori Tsuyoshi
School Of Pharmacy Hokuriku University
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Tomimori Tsuyoshi
Research Institute For Wakan-yaku (traditional Sino-japanese Medicine) Toyama Medical And Pharmaceut
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花岡 美代次
Institute Of Natural Medicine University Of Toyama
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Namba Tsuneo
Research Institute For Wakan-yaku (oriental Medicine) Toyama Medical And Pharmaceutical University
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KUSUMOTO INES
Research Institute for Wakan-Yaku (Traditional Sino-Japanese Medicines), Toyama Medical and Pharmace
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Kusumoto I
Research Institute For Wakan-yaku (traditional Sino-japanese Medicines) Toyama Medical And Pharmaceu
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MIYAICHI YUKINORI
Research Institute for Wakan-Yaku (Traditional Sino-Japanese Medicines), Toyama Medical and Pharmace
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HATTORI MASAO
Research Institute for Wakan-Yaku (Oriental Medicines)
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