Chemical Transformation of Protoberberines. XI. A Novel Synthesis of 2,3,10,11-Tetraoxygenated Protoberberine Alkaloids from Corresponding 2,3,9,10-Tetraoxygenated Protoberberine Alkaloids(Organic,Chemical)
スポンサーリンク
概要
- 論文の詳細を見る
2,3,9,10-Tetraoxygenated protoberberin alkaloids, berberine (1a). palmatine (1b), and coptisine (1c), were efficiently converted into the corresponding 12-hydroxy-2,3,10,11-tetraoxygenated protoberberines (6a, 6b, 6c) through an oxidative C_8-C_<8a> bond cleavage with m-chloroperbenzoic acid, followed by the enamide photo-cyclization. On successive treatment with diethyl chlorophosphate and sodium in liquid ammonia, the 12-hydroxy derivatives (6a, 6b, 6c) underwent reductive dehydroxylation to produce the correspondins 2,3,10,11-tetratoxygenated protoberberines, tetrahy-dropseudoberberine (4a), (±)-xylopinine (4b), and tetrahydropseudocoptisine (4c), respectively.
- 社団法人日本薬学会の論文
- 1987-01-25
著者
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花岡 美代次
Faculty of Pharmaceutical Sciences, Kanazawa University
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花岡 美代次
金沢大学薬学部
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花岡 美代次
Faculty Of Pharmaceutical Sciences Osaka University
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花岡 美代次
Faculty Of Pharmaceutical Sciences Kanazawa University
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向 智里
金沢大学薬学部
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向 智里
Faculty of Pharmaceutical Sciences, Kanazawa University
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趙 元済
Faculty of Pharmaceutical Sciences, Kanazawa University
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向 智里
Faculty Of Pharmaceutical Sciences Osaka University
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趙 元済
Faculty Of Pharmaceutical Sciences Kanazawa University
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丸谷 真理
Faculty of Pharmaceutical Sciences, Kanazawa University
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丸谷 真理
Faculty Of Pharmaceutical Sciences Kanazawa University
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