100(P24) 抗腫瘍性スチリルラクトン化合物の高立体選択的合成(ポスター発表の部)
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概要
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Several so-called antitumor styryllactones have recently been isolated from Goniothalamus giganteus in Thailand and shown to possess cytotoxic activities against human tumor cells. In the course of our program directed toward the development of highly stereoselective reactions mediated by (η^6-ο-trimethylsilylbenzaldehyde)chromium(0)complex(1) and their application to stereoselective syntheses of bioactive compounds, we now focused our effort on total syntheses of these antitumor styryllactones. By taking advantage of the chiral anti-aldol product 3, prepared from the reaction of 1 with the thioate 2 in a highly stereoselective manner, we could develop an efficient way for the synthesis of the γ-lactone 7, the first key compound of our syntheses of styryllactones, which was further transformed into the second key compound 11 for our purpose. Chemical transformation of the γ-lactone 7 and the δ-lactone 11 into all types antitumor styryllactones could be realized in an efficient and selective way. These details will be described in this symposium.
- 天然有機化合物討論会の論文
- 1996-09-02
著者
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平井 秀一
金沢大薬
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花岡 美代次
金沢大学薬学部
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向 智里
金沢大学薬学部
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向 智里
金沢大薬
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金 寅鍾
金沢大薬
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花岡 美代次
金沢大薬
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Hattori Masao
Metabolic Engineering Institute Of Natural Medicine University Of Toyama
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花岡 美代次
Institute Of Natural Medicine University Of Toyama
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