Developing of anti-HIV agents from natural resources(Chemical & Pharmacological study)

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概要

• 論文の詳細を見る

• rights: 本文データは和漢医薬学会の許諾に基づきCiNiiから複製したものであるMost drugs clinically used to suppress replication of HIV, the virus that causes AIDS, are nucleosides and their analogs, but their use is limited due to their severe toxicity, emerging drug resistance and cost. These challenges prompt the search for new anti-HIV-1 agents that are affordable for resource-poor countries and have fewer side effects. As an approach, traditional medicines from different places of the world were evaluated with a panel of in vitro bioassays [designed to monitor inhibition of HIV-1-induced cytopathic effect (CPE), and HIV essential enzymes; reverse transcriptase (RT), protease (PR), and integrase (IN)], and active leads were then isolated and identified. In this review, structurally diverse compounds that have potent anti-HIV activity were classified to CPE inhibitors (phorbol diterpenes), RT inhibitors (caffeic acid derivatives and polyphenols), PR-inhibitors (derivatives of oleanane, ursane and lupane type triterpenes). Other compounds included are IN inhibitors. Structural modification of the active compounds and conjugation with synthesized anti-HIV agents were carried out, which, hopefully, could help for developing novel and effective anti-HIV agents.

• 和漢医薬学会の論文

著者

• NAKAMURA Norio

  富山医科薬科大学和漢薬研究所

• Nakamura N

  Institute Of Natural Medicine University Of Toyama

• 花岡 美代次

  金沢大学薬学部

• Nakamura Norio

  Institute Of Natural Medicine University Of Toyama

• Ma Chaomei

  Inst. Of Natural Medicine Univ. Of Toyama

• HATTORI Masao

  Institute of Natural Medicine, University of Toyama

• Nakamura N

  Faculty Of Pharmaceutical Sciences Doshisha Women's College Of Liberal Arts

• Hattori Masao

  Institute Of Natural Medicine University Of Toyama

• Hattori Masao

  Research Institute For Wakan-yaku (traditional Sino-japanese Medicines) Toyama Medical And Pharmaceu

• Hattori M

  Research Institute For Wakan-yaku Toyama Medical And Pharmaceutical University

• MESELHY Meselhy

  Faculty of Pharmacy, Cairo University

• EL MEKKAWY

  Division of Pharmaceutical Industry, National Research Center

• MA Chaomei

  School of Pharmacy, Memorial University of Newfoundland

• TEWTRAKUL Supinya

  Faculty of Pharmaceutical Sciences, Prince of Songkla University

• TEWTRAKUL Supinya

  Institute of Natural Medicine, Toyama Medical and Pharmaceutical University

• Nakamura N

  Institute Of Natural Medicine Toyama Medical And Pharmaceutical University

• Meselhy M

  Toyama Medical And Pharmaceutical Univ. Toyama Jpn

• Meselhy Meselhy

  Faculty Of Pharmacy Cairo University

• Meselhy Meselhy

  (present Address)faculty Of Pharmacy Cairo University

• Tewtrakul Supinya

  Faculty Of Pharmaceutical Sciences Prince Of Songkla University

• Hattori M

  Institute Of Natural Medicine University Of Toyama

• El Mekkawy

  Division Of Pharmaceutical Industry National Research Center

• Hattori Masao

  Institute Of Natural Medicine Faculty Of Pharmaceutical Sciences

• Hattori Masao

  Metabolic Engineering Institute Of Natural Medicine University Of Toyama

• Nakamura Norio

  Institute Of Natural Medicine Toyama And Pharmaceutical University

• Nakamura Norio

  Institute Of Natural Medicine

• 花岡 美代次

  Institute Of Natural Medicine University Of Toyama

• El-Mekkawy Sahar

  Division of Pharmaceutical Industry, National Research Center

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