Chemical and Biological Evaluation of Germinated and Mature Antler-shaped Fruiting Bodies of Ganoderma lucidum
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概要
- 論文の詳細を見る
For the purpose of evaluating germinated (I) and mature (II) antler-shaped fruiting bodies of Ganoderma lucidum, aqueous extracts of both crude drugs were compared from the point of view of chemical constituents and antitumor activity. In both aqueous extracts, ganodermanontriol and ganoderic acid A were major components of Ganoderma alcohols and acids, respectively. However, the total lanostane-type triterpene content of II was 6times greater than that of I. The contents and compositions of the respective triterpenes were different from each other. However, the total polysaccharide contents of aqueous extracts of I and II were not significantly different, as indicated by 13.4 and 11.7%, respectively. The aqueous extracts of I and II showed inhibitory effects on the growth of s.c. transplanted Lewis lung carcinoma (LLC) in BDF-1 mice by intraperitoneal administration; an aqueous extract of I gave T/C values of 80.8 and 73.0% at doses of 100 and 500mg/kg/ di.p., and that of II, T/C values of 76.5 and 61.5% at the same doses, respectively, indicting the extracts I and II were similar antitumor activity.
- 日本生薬学会の論文
- 2004-06-20
著者
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Nakamura N
Institute Of Natural Medicine University Of Toyama
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Min Byung-sun
Coll. Of Pharmacy Catholic Univ. Of Daegu
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Min Byung
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
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Nakamura N
Faculty Of Pharmaceutical Sciences Doshisha Women's College Of Liberal Arts
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Gao Jiang-jing
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
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Gao Jiang
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
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Gao Jiang
Institute Of Natural Medicine Facully Of Pharmaceutical Sciences And Pharmaceutical University
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Hattori Masao
Research Institute For Wakan-yaku (traditional Sino-japanese Medicines) Toyama Medical And Pharmaceu
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Hattori M
Research Institute For Wakan-yaku Toyama Medical And Pharmaceutical University
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Hattori Masao
Department Of Metabolic Engineering Institute Of Natural Medicine Toyama Medical And Pharmaceutical
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LEE You
Korea Ginseng & Tobacco Research Institute
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Min Byung
Institute Of Natural Medicine Facully Of Pharmaceutical Sciences And Pharmaceutical University
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Nakamura N
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
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Min Byung-sun
Laboratory Of Immunomodulator Korea Research Institute Of Bioscience And Biotechnology
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Min Byung
Laboratory Of Immunomodulator Korea Research Institute Of Bioscience And Biotechnology
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Hattori M
Institute Of Natural Medicine University Of Toyama
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Hattori Masao
Institute Of Natural Medicine Faculty Of Pharmaceutical Sciences
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Lee You
Korea Ginseng & Tobacco Research Institute
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Nakamura Norio
Institute Of Natural Medicine Toyama And Pharmaceutical University
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Nakamura Norio
Institute Of Natural Medicine
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