Potent Anticonvulsant Paeonimetabolin-I Derivatives Obtained by Incubation of Paeoniflorin and Thiol Compounds with Lactobacillus brevis
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概要
- 論文の詳細を見る
Seventeen thiopaeonimetabolin-I adducts were obtained as mixtures of diastereoisomers after incubation of paeoniflorin with Lactobacillus brevis in the presence of various thiols. Four compounds, 8-(n-hexylthio)- (8), 8-cyclopentylthio-, 8-(p-tolyl)thio- and 8-benzoylthio- (18) paeonimetabolins, showed 100% protection against pentylenetetrazole-induced convulsions at doses of 0.125,0.25,or 0.50 mmol/kg, relative to valproic acid (100% protection at 1.5 mmol/kg). For 8 and 18,the principle anticonvulsant activity resided in the (7S)-isomers while (7R)-isomers showed muscle relaxation effects.
- 社団法人日本薬学会の論文
- 1998-09-15
著者
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MESELHY Meselhy
Research Center for Ethnomedicines, Institute of Natural Medicine, Toyama Medical and Pharmaceutical
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Nakamura N
Faculty Of Pharmaceutical Sciences Doshisha Women's College Of Liberal Arts
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WATANABE Hiroshi
Research Group for Biotechnology Development, Japan Atomic Energy Research Institute (JAERI-Takasaki
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Hattori Masao
Research Institute For Wakan-yaku (traditional Sino-japanese Medicines) Toyama Medical And Pharmaceu
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Hattori M
Research Institute For Wakan-yaku Toyama Medical And Pharmaceutical University
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NAKAMURA Norio
Research Institute for Wakan-Yaku, Toyama Medical and Pharmaceutical University
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ABDEL-HAFEZ Atef
Institute of Natural Medicine, Toyama Medical and Pharmaceutical University
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Mohamed Tarek
Department Of Pharmaceutical Medical Chemistry Faculty Of Pharmacy Assiut University
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EL-GENDY Mahmound
Department of Pharmaceutical Medical Chemistry, Faculty of Pharmacy, Assiut University
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MAHFOUZ Nadia
Department of Pharmaceutical Medical Chemistry, Faculty of Pharmacy, Assiut University
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ABDEL-HAFEZ Atef
Faculty of Pharmacy, Assiut University
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EL-GENDY Mahmoud
Faculty of Pharmacy, Assiut University
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MAHFOUZ Nadia
Faculty of Pharmacy, Assiut University
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MOHAMED Tarek
Faculty of Pharmacy, Assiut University
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Abdel-hafez Atef
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
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Nakamura N
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
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Meselhy M
Toyama Medical And Pharmaceutical Univ. Toyama Jpn
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Meselhy Meselhy
Faculty Of Pharmacy Cairo University
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Meselhy Meselhy
(present Address)faculty Of Pharmacy Cairo University
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Meselhy Meselhy
Research Center For Ethnomedicines Institute Of Natural Medicine Toyama Medical And Pharmaceutical U
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El-gendy Mahmound
Department Of Pharmaceutical Medical Chemistry Faculty Of Pharmacy Assiut University
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Watanabe H
Toyama Medical And Pharmaceutical Univ. Toyama Jpn
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Mahfouz Nadia
Department Of Pharmaceutical Medical Chemistry Faculty Of Pharmacy Assiut University
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Nakamura Norio
Research Institute For Wakan-yaku (oriental Medicines) Toyama Medical And Pharmaceutical University
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HATTORI MASAO
Research Institute for Wakan-Yaku (Oriental Medicines)
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