Functional compensation by transplantation of cell suspensions of embryonic mesencephalon into the striatum of rats with 6-hydroxydopamine lesions.
スポンサーリンク
概要
- 論文の詳細を見る
Neuronal cell suspensions were implanted into the striatum of female rats that showed apomorphine-induced rotation and a reduction in striatal dopamine after intranigral treatment with 6-hydroxydopamine. The apomorphine-induced rotation was significantly suppressed by the transplantation in 12 out of 64 rats. DOPA accumulation and dopamine level (6.3 and 3.4%, respectively, compared with those of uncompensated rats) in the striatum following treatment with an amino acid decarboxylase inhibitor were slightly restored in compensated rats.
- 公益社団法人 日本薬理学会の論文
著者
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WATANABE Hiroshi
Research Group for Biotechnology Development, Japan Atomic Energy Research Institute (JAERI-Takasaki
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Suda Hiroshi
Research Laboratory Santen Pharmaceutical Co. Ltd.
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TERASAWA Katsutoshi
University Hospital, Toyama Medical and Pharmaceutical University
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HIYAMA Yukitaka
University Hospital, Toyama Medical and Pharmaceutical University
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SEKIHARA Shun-ichi
Research Institute for Wakan-yaku, Toyama Medical and Pharmaceutical University
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SUDA Hiroshi
Research Institute for Wakan-yaku, Toyama Medical and Pharmaceutical University
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