EFFECTS OF d-COCLAURINE AND d-RETICULINE, BENZYLTETRA-HYDROISOQUINOLINE ALKALOIDS, ON LEVELS OF 3,4-DIHYDROXY-PHENYLACETIC ACID AND HOMOVANILLIC ACID IN THE MOUSE STRIATUM
スポンサーリンク
概要
- 論文の詳細を見る
An intracereboventricular injection of d-coclaurine (50μg), a benzyltetrahydro-isoquinoline alkaloid extracted from Magnolia salicifolia, produced a slight increase in 3,4-dihydroxyphenylacetic acid level and a significant increase in homovanillic acid level in the mouse striatum. Another alkaloid d-reticuline (200 μg) increased only homovaillic acid level. An intracerebroventricular pretreatment with d-colaurine (50 μg) did not antagonize suppressive effect of apomorphine on l-dopa formation produced by γ-butyrolactone (750 mg/kg i.p.) plus armatic amino acid decarboxylase inhibitor, NSD-1015 (100 mg/kg i.p.). These results suggest that d-coclaurine blocks postsynaptic but not presynaptic dopamine receptors in the mouse striatum.
- 公益社団法人日本薬学会の論文
著者
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WATANABE Hiroshi
Research Group for Biotechnology Development, Japan Atomic Energy Research Institute (JAERI-Takasaki
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Watanabe Kazuo
Laboratory Of Chemical Pharmacology Department Of Drug Evaluation And Toxicological Sciences Faculty
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Watanabe K
Department Of Drug Evaluation And Toxicological Sciences Faculty Of Pharmaceutical Sciences Chiba Un
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Watanabe Kazuo
Department Of Biology School Of Science Nagoya University
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Watanabe Kazuo
Department Of Drug Evaluation And Toxicological Sciences Chiba University
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KIKUCHI TORU
Research Institute for Wakan-yaku, Toyama Medical and Pharmaceutical University, Toyama
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Watanabe Kazuo
Department Of Biology Faculty Of Science Osaka University
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Kikuchi Toru
Research Institute For Wakan-yaku Toyama Medical And Pharmaceutical University Toyama
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