Effect of Pentobarbital on Gastric Acid Secretion Elicited by Secretagogues or Electrical Vagal Stimulation in Rats under Urethane Anesthesia
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概要
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The effect of pentobarbital, which stimulates gastric acid secretion in urethane-anesthetized rats, on secretagogue-stimulated or electrically stimulated acid secretion was studied in the rat perfused stomach. 2-Deoxy-D-glucose (2-DG)-stimulated gastric acid secretion was markedly depressed by intravenous injection of pentobarbital, but was definitely increased by lateral cerebroventricular injection and was unaffected by injection into the fourth cerebroventricle. Bethanechol-stimulated secretion was augmented by intravenous injection of pentobarbital. In vagotomized rats, pentobarbital did not affect the bethanechol-stimulated or electrically vagally stimulated secretion. These findings indicate that pentobarbital produces both stimulatory and inhibitory effects on gastric acid secretion through a central mechanism, especially in the forebrain. It was proposed that the inhibitory response would result from some interaction of intravenous 2-DG and pentobarbital in the central regulatory system of gastric secretion.
- 公益社団法人日本薬学会の論文
著者
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Watanabe K
Nihon Univ. Chiba Jpn
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Yano S
Chiba Univ. Chiba Jpn
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Yano Shingo
Laboratory Of Molecular Pharmacology & Pharmacotherapeutics Graduate School Of Pharmaceutical Sc
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LIN WenC.
Laboratory of Chemical Pharmacology, Department of Drug Evaluation and Toxicological Sciences, Facul
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WATANABE Kazuo
Laboratory of Chemical Pharmacology, Department of Drug Evaluation and Toxicological Sciences, Facul
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Lin Wenc.
Laboratory Of Chemical Pharmacology Department Of Drug Evaluation And Toxicological Sciences Faculty
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Watanabe Kazuo
Laboratory Of Chemical Pharmacology Department Of Drug Evaluation And Toxicological Sciences Faculty
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Watanabe Kazuo
Laboratory Of Applied Botany Faculty Of Agriculture Kyoto University
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YANO Shingo
Laboratory of Chemical Pharmacology, Department of Drug Evaluation and Toxicological Sciences, Faculty of Pharmaceutical Sciences, Chiba University
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