Change in Formation of Gastric Lesions by Aspirin during Aging in Rats
スポンサーリンク
概要
- 論文の詳細を見る
Formation of gastric lesions induced by orally administered aspirin (100 mg/kg) was examined in 4 to 86 week-old Sprague-Dawley male rats. Gastric mucosal prostaglandin I_2 (PGI_2) level and gastric secretion in basal state were also examined in these rats. Gastric mucosal PGI_2 level was measured by bioassay and gastric secretion was collected by the pyloric ligation method for 4 h. Gastric lesions reached the maximum value in 7 week-old, and lowest in 60 week-old. Acid output also reached the maximum value in 7 week-old. As for PGI_2 level, it showed the maximum value in 20 week-old, and moderately decreased thereafter. In 86 week-old, PGI_2 level was further lowered to about 35% of 20 week-old rats. A linear positive correlation was noted between formation of aspirin-induced gastric lesion and acid secretion. From these results, it was concluded that formation of gastric lesions by aspirin was closely related to acidity of the gastric secretion. It was also suggested that in aged rats, aspirin-induced gastric lesions may at least partly be associated with the reduced PGI_2 level.
- 公益社団法人日本薬学会の論文
著者
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WATANABE Kazuo
Department of Pathology, Fukushima Medical University Hospital
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Uchida Masayuki
Food Functionality Research Institute Meiji Milk Products Co. Ltd.
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Kawano Osamu
Research Laboratories Grelan Pharmaceutical Co. Ltd.
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Uchida M
Food Functionality Research Institute Meiji Milk Products Co. Ltd.
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Uchida M
Research Laboratories Grelan Pharmaceutical Co. Ltd.:department Of Drug Evaluation And Toxicological
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UCHIDA Masayuki
Research Laboratories, Grelan Pharmaceutical Co., Ltd.
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Watanabe Kazuo
Department Of Pathology Fukushima Medical University Hospital
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Watanabe Kazuo
Laboratory Of Chemical Pharmacology Department Of Drug Evaluation And Toxicological Sciences Faculty
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Watanabe K
Department Of Drug Evaluation And Toxicological Sciences Faculty Of Pharmaceutical Sciences Chiba Un
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Watanabe Kazuo
Department Of Biology School Of Science Nagoya University
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Watanabe Kazuo
Department Of Drug Evaluation And Toxicological Sciences Faculty Of Pharmaceutical Sciences Chiba Un
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Watanabe Kazuo
Department Of Drug Evaluation And Toxicological Sciences Chiba University
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Watanabe Kazuo
Department Of Biology Faculty Of Science Osaka University
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