Healing process of acetic acid-induced gastric ulcer and gastric mucosal prostaglandin E generation level in rats.

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概要

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• The prostaglandin E (PGE) generation level (PGE level) in the gastric mucosa was investigated in relation to the healing and relapse of acetic acid-induced gastric ulcers in the rat. The PGE level around ulcers showed higher levels after ulcer induction and decreased during the ulcer diminishing period. Thereafter, the PGE levels showed an inclination to increase during the ulcer exacerbation period. In reulcerated rats, PGE levels were significantly higher. In conclusion, a high level of PGE may indicate an ulcer exacerbation state.

• 公益社団法人 日本薬理学会の論文

著者

• Kawano Osamu

  Research Laboratories Grelan Pharmaceutical Co. Ltd.

• UCHIDA Masayuki

  Research Laboratories, Grelan Pharmaceutical Co., Ltd.

• Irino Osamu

  Research Lab. Grelan Pharmaceutical Co. Ltd.

• MISAKI Noriyuki

  Research Laboratories, Grelan Pharmaceutical Co., Ltd.

• KAWANO Osamu

  Research Laboratories, Grelan Pharmaceutical Co., Ltd.

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• Healing process of acetic acid-induced gastric ulcer and gastric mucosal prostaglandin E generation level in rats.
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