Effects of ifenprodil glucuronide derivative on platelet aggregation and vasocontraction.
スポンサーリンク
概要
- 論文の詳細を見る
It has been supposed that ifenprodil glucuronide derivative, detectable in large amount in rabbit plasma, is related to the pharmacological actions by ifenprodil tartrate. However, a synthesized ifenprodil glucuronide derivative was found to have no effect on platelet aggregation and vasocontraction in vitro. These results indicate that ifenprodil itself rather than its glucoronide derivative manifested the pharmacological actions.
- 公益社団法人 日本薬理学会の論文
著者
-
Saitoh Kiyoshi
Research Lab. Grelan Pharmaceutical Co. Ltd.
-
Irino Osamu
Research Lab. Grelan Pharmaceutical Co. Ltd.
-
Manabe Tatsuo
Research Lab. Grelan Pharmaceutical Co. Ltd.
-
MANABE Tatsuo
Research Laboratory, Grelan Pharmaceutical, Co., Ltd.
-
HONDA Hideo
Research Laboratory, Grelan Pharmaceutical, Co., Ltd.
-
SAITOH Kiyoshi
Research Laboratory, Grelan Pharmaceutical, Co., Ltd.
関連論文
- DISPOSITION OF IFENPRODIL TARTRATE AND MANIFESTATION OF ANTI-PLATELET EFFECTS IN HUMAN AND ANIMALS
- Healing process of acetic acid-induced gastric ulcer and gastric mucosal prostaglandin E generation level in rats.
- Effects of ifenprodil glucuronide derivative on platelet aggregation and vasocontraction.