γ-BUTYROLACTONE ENHANCES THE ACTIVITY OF GABA IN THE GASTRIC ACID SECRETION OF ANESTHETIZED RATS
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概要
- 論文の詳細を見る
Influences of γ-butyrolactone (GBL) on GABA agonists-induced gastric acid secretion were studied in anesthetized rats. GBL potentiated the effect of GABA and GABA agonists on gastric acid secretion, and γ-hydroxybutyric acid, a metabolite of GBL, tended to enhance the effect of GABA. However, GBL did not influence 2-deoxy-D-glucose or bethanechol-stimulated acid secretion. A benzodiazepine, diazepam, also increased the secretagogue action of baclofen. A GABA antagonist, bicuculline, but not picrotoxin, inhibited the acid secretion stimulated by the combination of GBL and GABA or muscimol. Aminooxyacetic acid, an inhibitor of GABA transaminase, potentiated the effect of GABA. Dopamine receptor agonists and antagonist did not modify the effect of GABA. Neither GABA mimetic action of GBL nor its influences on the dopaminergic system are involved in the effect of the compound on gastric acid secretion. Although the possibility that GBL inhibits GABA degradation is not excluded, the compound appears to increase the sensitivity of GABA receptor to GABA mimetics in the gastric acid secretion.
- 社団法人 日本薬理学会の論文
著者
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GOTO Yoshiaki
Department of Electrical and Electronic Engineering, Akita University
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WATANABE Kazuo
Department of Pathology, Fukushima Medical University Hospital
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Watanabe Hiroshi
Department of Cardiology, Niigata City General Hospital
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Goto Yoshiaki
Department Of Cardiology Gifu Prefectural General Medical Center
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Watanabe K
Nihon Univ. Chiba Jpn
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Shimizu Masao
Department Of Applied Physics Faculty Of Engineering Nagoya University
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MAEDA-HAGIWARA Masaki
Department of Pharmacometrics, Research Institute for Wakan-yaku, Toyama Medical & Pharmaceutical Un
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Watanabe Kazuo
Department Of Pathology Fukushima Medical University Hospital
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Goto Yoshiaki
Department Of Agricultural Chemistry Nagoya University
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Watanabe Kazuo
Department Of Biology Faculty Of Science Osaka University
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Watanabe Hiroshi
Department Of Applied Chemistry And Bioengineering Graduate School Of Engineering Osaka City Univers
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WATANABE Kazuo
Department of Pharmacometrics, Research Institute for Wakan-yaku, Toyama Medical & Pharmaceutical University
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MAEDA-HAGIWARA Masaki
Department of Pharmacology, Research Institute for Wakan-yaku, Toyama Medical & Pharmaceutical University
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