Association of Chlamydia Pneumoniae Infection and Carotid Intima-Media Wall Thickness in Japanese Americans
スポンサーリンク
概要
- 論文の詳細を見る
Background Chlamydia pneumoniae (Cp) infection has been proposed as a risk factor for coronary artery disease (CAD), but it remains unclear whether Cp plays a role in the progression of early stage carotid atherosclerosis. Methods and Results The associations among Cp IgG/IgA antibodies, inflammation markers such as C-reactive protein (CRP) and interleukin (IL)-6, and the maximal progression of carotid intima-media wall thickness (max IMT) were evaluated using ultrasonography in 259 Japanese Americans. The presence of Cp IgG or IgA antibodies itself did not show significant correlation with max IMT after adjustment for age and sex. However, in the Cp IgG seropositive group, the subjects with high IL-6 levels showed more pronounced max IMT progression than those with low IL-6 levels after adjustment of the other CAD risk factors. Moreover, in the Cp IgA seropositive group, the subjects with high CRP or IL-6 levels had significantly higher levels of max IMT compared with those with low CRP or IL-6. Conclusions The results support the hypothesis that a chronic latent Cp infection with inflammation might accelerate the development of early stage atherosclerotic lesions.
- 社団法人日本循環器学会の論文
- 2006-06-20
著者
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YAMANE Kiminori
Department of Molecular and Internal Medicine, Graduate School of Biomedical Sciences, Hiroshima Uni
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NAKANISHI Shuhei
Department of Molecular and Internal Medicine, Graduate School of Biomedical Sciences, Hiroshima Uni
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KOHNO Nobuoki
Department of Molecular and Internal Medicine, Graduate School of Biomedical Sciences, Hiroshima Uni
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Tasaki Naohito
Department of Molecular Medicine, Hiroshima University Graduate School
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Watanabe Hiroshi
Department of Cardiology, Niigata City General Hospital
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Nakanishi Shuhei
Department Of Molecular And Internal Medicine Graduate School Of Biomedical Sciences Hiroshima Unive
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Nakanishi Shuhei
広島大学 医歯学総合研究科分子内科学
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Kohno Nobuoki
Department Of Molecular And Internal Medicine Graduate School Of Biomedical Sciences Hiroshima Unive
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Kohno Nobuoki
広島大学 医歯薬学総合研究科分子内科学
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Kohno Nobuoki
Department Of Molecular And Internal Medicine Hiroshima University Graduate School Of Biomedical Sci
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Jitsuiki Kuniaki
Department of Molecular and Internal Medicine, Division of Clinical Medical Science, Programs for Ap
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Nakajima Masamitsu
Department of Molecular and Internal Medicine, Division of Clinical Medical Science, Programs for Ap
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Kurihara Hidemi
Department of Periodontal Medicine, Division of Frontier Medical Science, Graduate School of Biomedi
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Tasaki Naohito
Department Of Molecular And Internal Medicine Hiroshima University
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Tasaki Naohito
Department Of Cardiology Hiroshima General Hospital
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Tasaki Naohito
Department Of Molecular And Internal Medicine Division Of Clinical Medical Science Programs For Appl
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Kohno Nobuoki
Department Of Internal Medicine Hiroshima University Graduate School Of Medicine
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Kohno Nobuoki
Second Department Of Internal Medicine Hiroshima University School Of Medicine
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Nakajima Masamitsu
Department Of Molecular And Internal Medicine Division Of Clinical Medical Science Programs For Appl
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Yamane Kiminori
Department Of Molecular And Internal Medicine Graduate School Of Biomedical Sciences Hiroshima Unive
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Yamane Kiminori
Department Of Molecular And Internal Medicine Graduate School Biomedical Sciences Hiroshima Universi
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Yamane Kiminori
Department Of Molecular And Internal Medicine Division Of Clinical Medical Science Programs For Appl
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Kohno Nobuoki
Department Of Molecular And Internal Medicine Division Of Clinical Medical Science Programs For Appl
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Kurihara Hidemi
Department Of Endodontology And Periodontology Hiroshima University School Of Dentistry
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Kurihara Hidemi
Department Of Periodontal Medicine Division Of Frontier Medical Science Graduate School Of Biomedica
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Jitsuiki Kuniaki
Department Of Molecular And Internal Medicine Division Of Clinical Medical Science Programs For Appl
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Kohno Nobuoki
Department Of Molecular And Internal Medicine Hiroshima University Graduate School Of Biomedical Sci
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Kohno Nobuoki
Department Of Molecular And Internal Medicine Graduate School Of Biomedical Sciences Hiroshima Unive
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Kohno Nobuoki
Department Of Molecular And Internal Medicine Graduate School Of Biomedical Sciences Hiroshima Unive
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Watanabe Hiroshi
Department Of Molecular And Internal Medicine Graduate School Biomedical Sciences Hiroshima Universi
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Watanabe Hiroshi
Department Of Applied Chemistry And Bioengineering Graduate School Of Engineering Osaka City Univers
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