Association of Chlamydia Pneumoniae Infection and Carotid Intima-Media Wall Thickness in Japanese Americans

元データ 2006-06-20 社団法人日本循環器学会

概要

Background Chlamydia pneumoniae (Cp) infection has been proposed as a risk factor for coronary artery disease (CAD), but it remains unclear whether Cp plays a role in the progression of early stage carotid atherosclerosis. Methods and Results The associations among Cp IgG/IgA antibodies, inflammation markers such as C-reactive protein (CRP) and interleukin (IL)-6, and the maximal progression of carotid intima-media wall thickness (max IMT) were evaluated using ultrasonography in 259 Japanese Americans. The presence of Cp IgG or IgA antibodies itself did not show significant correlation with max IMT after adjustment for age and sex. However, in the Cp IgG seropositive group, the subjects with high IL-6 levels showed more pronounced max IMT progression than those with low IL-6 levels after adjustment of the other CAD risk factors. Moreover, in the Cp IgA seropositive group, the subjects with high CRP or IL-6 levels had significantly higher levels of max IMT compared with those with low CRP or IL-6. Conclusions The results support the hypothesis that a chronic latent Cp infection with inflammation might accelerate the development of early stage atherosclerotic lesions.

著者

YAMANE Kiminori Department of Molecular and Internal Medicine, Graduate School of Biomedical Sciences, Hiroshima Uni
NAKANISHI Shuhei Department of Molecular and Internal Medicine, Graduate School of Biomedical Sciences, Hiroshima Uni
KOHNO Nobuoki Department of Molecular and Internal Medicine, Graduate School of Biomedical Sciences, Hiroshima Uni
Tasaki Naohito Department of Molecular Medicine, Hiroshima University Graduate School
Watanabe Hiroshi Department of Cardiology, Niigata City General Hospital
Nakanishi Shuhei Department Of Molecular And Internal Medicine Graduate School Of Biomedical Sciences Hiroshima Unive
Nakanishi Shuhei 広島大学 医歯学総合研究科分子内科学
Kohno Nobuoki Department Of Molecular And Internal Medicine Graduate School Of Biomedical Sciences Hiroshima Unive
Kohno Nobuoki 広島大学 医歯薬学総合研究科分子内科学
Kohno Nobuoki Department Of Molecular And Internal Medicine Hiroshima University Graduate School Of Biomedical Sci
Jitsuiki Kuniaki Department of Molecular and Internal Medicine, Division of Clinical Medical Science, Programs for Ap
Nakajima Masamitsu Department of Molecular and Internal Medicine, Division of Clinical Medical Science, Programs for Ap
Kurihara Hidemi Department of Periodontal Medicine, Division of Frontier Medical Science, Graduate School of Biomedi
Tasaki Naohito Department Of Molecular And Internal Medicine Hiroshima University
Tasaki Naohito Department Of Cardiology Hiroshima General Hospital
Tasaki Naohito Department Of Molecular And Internal Medicine Division Of Clinical Medical Science Programs For Appl
Kohno Nobuoki Department Of Internal Medicine Hiroshima University Graduate School Of Medicine
Kohno Nobuoki Second Department Of Internal Medicine Hiroshima University School Of Medicine
Nakajima Masamitsu Department Of Molecular And Internal Medicine Division Of Clinical Medical Science Programs For Appl
Yamane Kiminori Department Of Molecular And Internal Medicine Graduate School Of Biomedical Sciences Hiroshima Unive
Yamane Kiminori Department Of Molecular And Internal Medicine Graduate School Biomedical Sciences Hiroshima Universi
Yamane Kiminori Department Of Molecular And Internal Medicine Division Of Clinical Medical Science Programs For Appl
Kohno Nobuoki Department Of Molecular And Internal Medicine Division Of Clinical Medical Science Programs For Appl
Kurihara Hidemi Department Of Endodontology And Periodontology Hiroshima University School Of Dentistry
Kurihara Hidemi Department Of Periodontal Medicine Division Of Frontier Medical Science Graduate School Of Biomedica
Jitsuiki Kuniaki Department Of Molecular And Internal Medicine Division Of Clinical Medical Science Programs For Appl
Kohno Nobuoki Department Of Molecular And Internal Medicine Hiroshima University Graduate School Of Biomedical Sci
Kohno Nobuoki Department Of Molecular And Internal Medicine Graduate School Of Biomedical Sciences Hiroshima Unive
Kohno Nobuoki Department Of Molecular And Internal Medicine Graduate School Of Biomedical Sciences Hiroshima Unive
Watanabe Hiroshi Department Of Molecular And Internal Medicine Graduate School Biomedical Sciences Hiroshima Universi
Watanabe Hiroshi Department Of Applied Chemistry And Bioengineering Graduate School Of Engineering Osaka City Univers

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