An α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Antagonist and an N-Methyl-D-aspartate (NMDA) Channel Blocker Synergistically Impair Spatial Memory in Rats
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概要
- 論文の詳細を見る
The interaction of the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) antagonist YM90K with the competitive N-methyl-D-aspartate (NMDA) antagonist CGS19755 or with the NMDA channel blocker MK801 on the spatial memory of rats was examined by the 4-arm-baited radial maze task. When administered alone, these drugs had no effect on the spatial memory. The combination YM90K and MK801 synergistically disrupted working and reference memories, whereas the combination of YM90K and CGS19755 had no effect. These results indicate that the blockade of the AMPA recepor and NMDA channels produces a synergistic impairment of spatial memory and suggest that interaction between the AMPA and NMDA receptors plays a role in congnitive function.
- 社団法人日本薬学会の論文
- 1998-11-15
著者
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Watanabe Hiroshi
Department of Cardiology, Niigata City General Hospital
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MATSUMOTO Kinzo
Department of Pharmacology, Institute of Natural Medicine, Toyama Medical and Pharmaceutical Univers
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Matsumoto Kinzo
Department Of Pharmacology Research Insitute For Wakan-yaku (oriental Medicines) Toyama Medical And
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Matsumoto Kinzo
Department Of Pharmacology Institute Of Natural Medicine:21st Century Coe Program Toyama Medical And
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LI Hongbin
Department of Pharmacology, Research Insitute for Wakan-Yaku (Oriental Medicines), Toyama Medical an
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Li Hongbin
Department Of Pharmacology Research Insitute For Wakan-yaku (oriental Medicines) Toyama Medical And
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Watanabe Hiroshi
Department Of Applied Chemistry And Bioengineering Graduate School Of Engineering Osaka City Univers
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