DNA array analysis of gene expression changes by Choto-san in the ischemic rat brain
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概要
- 論文の詳細を見る
痴呆モデル動物である両側総頸動脈永久結紮ラット脳中での釣藤散による遺伝子発現変化をDNAマイクロアレイ法により検討した。被検4,277種の遺伝子中181種類の発現が脳虚血4日後の脳中で上昇し,釣藤散1g/kg 1日1回3日間経口投与により回復することが明らかとなった。また,32種類の発現が,脳虚血により減少し,釣藤散で回復することもわかった。この結果より,釣藤散は関連遺伝子の発現変化を介して抗痴呆効果をあらわしている可能性が考えられる。
- 和漢医薬学会の論文
- 2004-08-20
著者
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東田 道久
富山医科薬科大学和漢薬研究所生物試験部門
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渡邉 裕司
富山医科薬科大学和漢薬研究所生物試験部門
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Tohda Michihisa
和漢医薬学総合研究所 複合薬物薬理学分野
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Tohda Michihisa
富山医科薬科大学和漢薬研究所
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Tohda Michihisa
タイ
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Tohda Michihisa
和漢医薬学総合研究所 複合薬物薬理学
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渡辺 裕司
International Research Center For Traditional Medicine Toyama Prefecture International Health Comple
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Watanabe Hiroshi
Department of Cardiology, Niigata City General Hospital
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MURAKAMI Yukihisa
Department of Pharmacology, Institute of Natural Medicine, Toyama Medical and Pharmaceutical Univers
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MATSUMOTO Kinzo
Department of Pharmacology, Institute of Natural Medicine, Toyama Medical and Pharmaceutical Univers
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Murakami Yukihisa
Department Of Pharmacology Institute Of Natural Medicine:21st Century Coe Program Toyama Medical And
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渡邉 浩司
富山医科薬科大学和漢薬研究所生物試験部門
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HAYASHI HISAE
Department of Cardiovascular Surgery, Tokyo Women's Medical College
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Tohda Michihisa
Department Of Pharmacology Institute Of Natural Medicine (wakan-yaku) Toyama Medical And Pharmaceuti
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Matsumoto Kinzo
Department Of Pharmacology Institute Of Natural Medicine:21st Century Coe Program Toyama Medical And
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Watanabe H
Health Science University Of Hokkaido
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Watanabe Hiroshi
Radia Industry Co. Ltd
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Hayashi Hisae
Department Of Pharmacology Institute Of Natural Medicine
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渡邉 裕司
富山医科薬科大学生物試験部門
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Tohda M
Department Of Pharmacology Institute Of Natural Medicine Toyama Medical And Pharmaceutical Universit
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東田 道久
Division Of Medicinal Pharmacology Institute Of Natural Medicine University Of Toyama
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Watanabe Hiroshi
Biotechnology Laboratory Japan Atomic Energy Research Institute
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Watanabe Hiroshi
Department Of Applied Chemistry And Bioengineering Graduate School Of Engineering Osaka City Univers
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