Panax ginseng Extract Improves the Scopolamine-Induced Disruption of 8-Arm Radial Maze Performance in Rats
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概要
- 論文の詳細を見る
The effects of Panax ginseng ethanol extract and its water (WSF)-and lipid-soluble (LSF) fractions on the scopolamine-induced disruption of radial maze performance in rats were examined. Ginseng root was refluxed with ethanol, and WSF and LSF were prepared from this ethanol extract. Scopolamine (0.075-0.3mg/kg, i.p.) dose-dependently impaired the maze performance. However, the oral administration of Panax ginseng ethanol extract and WSF (2-8g dried root/kg) 90min before testing improved the maze performance disrupted by scopolamine (0.3mg/kg) in a dose-dependent manner, but LSF failed to attenuate the disruption. These data suggest that ginseng extract possesses a beneficial effect regarding spatial cognitive impairment and that the water-soluble fraction of ginseng extract mainly contributes to the effect of the ethanol extract.
- 社団法人日本薬学会の論文
- 1995-10-15
著者
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清水 岑夫
富山医科薬科大学薬学部
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渡辺 裕司
International Research Center For Traditional Medicine Toyama Prefecture International Health Comple
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新田 浩之
富山医科薬科大学和漢薬研究所生物試験部門
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新田 浩之
Division of Pharmacology, Research Institute for Wakan-Yaku (Oriental Medicines) Toyama Medical and
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松本 欣三
Division of Pharmacology, Research Institute for Wakan-Yaku (Oriental Medicines) Toyama Medical and
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清水 岑夫
Laboratory of Pharmacognosy, Department of Medicinal Resources, Faculty of Pharmaceutical Sciences T
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倪 小虎
Division of Pharmacology, Research Institute for Wakan-Yaku (Oriental Medicines) Toyama Medical and
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渡辺 裕司
Division of Pharmacology, Research Institute for Wakan-Yaku (Oriental Medicines) Toyama Medical and
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清水 岑夫
Faculty Of Pharmaceutical Science Toyama Medical And Pharmaceutical University
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清水 岑夫
富山医科薬科大学薬
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清水 岑夫
富山大学薬学部
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清水 岑夫
富山医科薬科大学和漢薬研究所
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清水 岑夫
Faculty Of Pharmaceutical Science
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松本 欣三
富山大学和漢医薬学総合研究所複合薬物薬理学
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倪 小虎
Division Of Pharmacology Research Institute For Wakan-yaku (oriental Medicines) Toyama Medical And P
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Ni Xiao-hu
Division Of Pharmacology Research Institute For Wakan-yaku (oriental Medicines)
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Matsumoto Kinzo
Division Of Pharmacology Research Institute For Wakan-yaku (oriental Medicines)
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Nitta Hiroyuki
Division Of Pharmacology Research Institute For Wakan-yaku (oriental Medicines)
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渡辺 裕司
Division of Medicinal Pharmacology, Institute of Natural Medicine, University of Toyama
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