Antinociceptive and Antipyretic Effects of Alkaloids Extracted from the Stem Bark of Hunteria zeylanica
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概要
- 論文の詳細を見る
Effects of crude alkaloids extracted from the stem bark of Hunteria zeylanica GARD. (H. zeylanica) on nociceptive responses, capillary permeability, yeast-induced hyperthermia, pentobarbital-induced sleep, and spontaneous motor activity were investigated. Oral administration of 50 mg/kg H. zeylanica alkaloid extract significantly decreased the number of writhings induced by intraperitoneal acetic acid. The extract at 100-200 mg/kg significantly increased nociceptive threshold of the inflamed but not the non-inflamed paw in the Randall-Selitto test. Moreover, in the formalin test, the extract (100 mg/kg) significantly decreased licking activity in the late phase without affecting the activity in the early phase. However, the extract did not produce antinociceptive effect in the hot plate test, while it inhibited increase of vascular permeability induced by acetic acid in the capillary permeability test. Moreover, the extract dose-dependently reduced yeast-induced hyperthermia in rats without affecting normothermia. It did not affect pentobarbital-induced sleep, but significantly increased locomotor activity at 100 mg/kg. These results suggest that H. zeylanica alkaloid extract possesses antinociceptive and antipyretic effects, and that the former effect may be mediated by its anti-inflammatory action.
- 公益社団法人日本薬学会の論文
- 1994-10-15
著者
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坂井 進一郎
千葉大院薬
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坂井 進一郎
Department of Medicinal Materials
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渡辺 裕司
International Research Center For Traditional Medicine Toyama Prefecture International Health Comple
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松本 欣三
Division of Pharmacology, Research Institute for Wakan-Yaku (Oriental Medicines) Toyama Medical and
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渡辺 裕司
Division of Pharmacology, Research Institute for Wakan-Yaku (Oriental Medicines) Toyama Medical and
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松本 欣三
富山大学和漢医薬学総合研究所複合薬物薬理学
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坂井 進一郎
Showa College of Pharmaceutical Sciences
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SUBHADHIRASAKUL Sanan
Department of Pharmaceutical Botany and Pharmacognosy, Faculty of Pharmaceutical Sciences, Prince of
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REANMONGKOL Wantana
Division of Pharmacology, Research Institute for Wakan-Yaku (Oriental Medicines), Toyama Medical and
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Matsumoto Kinzo
Division Of Pharmacology Research Institute For Wakan-yaku (oriental Medicines)
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佐々木 茂貴
Faculty Of Pharmaceutical Sciences Kyushu University
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Reanmongkol Wantana
Division Of Pharmacology Research Institute For Wakan-yaku (oriental Medicines) Toyama Medical And P
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坂井 進一郎
Thailand And Department Of Pharmaceutical Chemistry Faculty Of Pharmaceutical Sciences Chiba Univers
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Subhadhirasakul Sanan
Department Of Pharmaceutical Botany And Pharmacognosy Faculty Of Pharmaceutical Sciences Prince Of S
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/ 松本
Division of Pharmacology, Research Institute for Wakan-Yaku, Toyama Medical and Pharmaceutical University
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Subhadhirasakul Sanan
Department of Molecular Medicinal Sciences, Graduate School of Biomedical Sciences, Nagasaki University
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渡辺 裕司
Division of Medicinal Pharmacology, Institute of Natural Medicine, University of Toyama
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