A Convenient Synthesis of 1,2,3,4,6,7,12,12b-Octahydroindolo-[2,3-α]quinolizine Derivatives
スポンサーリンク
概要
- 論文の詳細を見る
Convenient syntheses of 1,2,3,4,6,7,12,12b-octahydroindolo[2,3-α]quinolizine derivatives (4a, b) and a relatd unsaturated lactam (14) are described. The condensation of tryptamine (1) with 8a, b (prepared from 7a, b by decarboethoxylation), followed by treatment with alkali gave the lactams (4a, b), respectively. The stereochemistry of 4b was determined by conversion to the known cis- and trans-compounds (5b). The condensation of 1 with the sulfenylated ester (10), which was prepared in two ways, followed by treatment with alkali gave the lactams (12a, b). Oxidation of 12a, b with m-chloroperbenzoic acid gave the sulfoxides (13) which were heated at 50℃ to give the lactams (14,15) and the pyridone (16).
- 公益社団法人日本薬学会の論文
- 1986-01-25
著者
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坂井 進一郎
千葉大院薬
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坂井 進一郎
Faculty of Pharmaceutical Sciences, Chiba University
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山中 悦二
Department Of Medicinal Materials:faculty Of Pharmaceutical Sciences Chiba University
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山中 悦二
Faculty of Pharmaceutical Sciences, Chiba University
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成嶋 真弓
Faculty of Pharmaceutical Sciences, Chiba University
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犬飼 邦江(旧姓長島)
Faculty of Pharmaceutical Sciences, Chiba University
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坂井 進一郎
Faculty Of Pharmaceutical Sciences Chiba University
-
犬飼 邦江(旧姓長島)
Faculty Of Pharmaceutical Sciences Chiba University
-
成嶋 真弓
Faculty Of Pharmaceutical Sciences Chiba University
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