Inhibitory Effects of Corymine-Related Compounds on Glycine Receptors Expressed in Xenopus Oocytes
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概要
- 論文の詳細を見る
We examined the effects of 4 corymine-related compounds on glycine-induced chloride current in Xenopus oocytes. Dihydrocorymine, N-demethyl-3-epi-dihydrocorymine and deformylcorymine dose-dependently decreased the glycine current with IC50 values of 34, 37 and 55 μM, respectively. The effect of these compounds on the glycine current was more potent than that of pleiocarpamine (IC50 > 1 mM). N-Demethyl-3-epi-dihydrocorymine and dihydrocorymine, at 100 μM, also decreased the γ-aminobutyric acid-induced current by 65% and 22%, respectively, whereas deformylcorymine and pleiocarpamine failed. The inhibitory action of deformylcorymine on the glycine current was noncompetitive. These results suggest that deformylcorymine is a novel specific noncompetitive glycine receptor antagonist. The structure-activity relationship of these compounds was discussed.
- 社団法人 日本薬理学会の論文
- 1998-06-01
著者
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Tohda Michihisa
和漢医薬学総合研究所 複合薬物薬理学分野
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Tohda Michihisa
Department Of Pharmacology Institute Of Natural Medicine Toyama Medical And Pharmaceutical Universit
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渡辺 裕司
International Research Center For Traditional Medicine Toyama Prefecture International Health Comple
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Watanabe Hiroshi
Department of Cardiology, Niigata City General Hospital
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高山 廣光
Graduate School Of Pharmaceutical Sciences Chiba Univ.
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LEEWANICH Pathama
Department of Pharmacology, Faculty of Medicine, Srinakharinwirot University
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MATSUMOTO Kinzo
Department of Pharmacology, Institute of Natural Medicine, Toyama Medical and Pharmaceutical Univers
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TAKAYAMA Hiromitsu
Faculty of Pharmaceutical Sciences, Chiba University
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AIMI Norio
Faculty of Pharmaceutical Sciences, Chiba University
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SUBHADHIRASAKUL Sanan
Department of Pharmaceutical Botany and Pharmacognosy, Faculty of Pharmaceutical Sciences, Prince of
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Sakamoto Saori
Department Of Molecular Medicinal Sciences Graduate School Of Biomedical Sciences Nagasaki Universit
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Tohda Michihisa
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Hokkaido University
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Matsumoto Kinzo
Div. Of Medicinal Pharmacology Inst. Of Natural Medicine Univ. Of Toyama
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Matsumoto Kinzo
Department Of Pharmacology Institute Of Natural Medicine:21st Century Coe Program Toyama Medical And
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Leewanich Pathama
Department Of Pharmacology Faculty Of Medicine Srinakharinwirot University
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Takayama Hiromitsu
Laboratory Of Molecular Structure And Biological Function Graduate School Of Pharmaceutical Sciences
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Matsumoto Kinzo
富山大学和漢医薬学総合研究所 複合薬物薬理学
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Sakamoto S
Department Of Molecular Medicinal Sciences Graduate School Of Biomedical Sciences Nagasaki Universit
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Aimi N
Graduate School Of Pharmaceutical Sciences Chiba University
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Aimi Norio
Faculty Of Pharmaceutical Sciences Chiba University
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Watanabe H
Division Of Medicinal Pharmacology Institute Of Natural Medicine University Of Toyama
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Takayama Hiromitsu
Faculty Of Pharmaceutical Sciences Chiba University
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Sakai S
Faculty Of Pharmaceutical Sciences Prince Of Songkla University
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Watanabe Hiroshi
Department Of Applied Chemistry And Bioengineering Graduate School Of Engineering Osaka City Univers
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Subhadhirasakul Sanan
Department Of Pharmaceutical Botany And Pharmacognosy Faculty Of Pharmaceutical Sciences Prince Of S
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Subhadhirasakul Sanan
Department of Molecular Medicinal Sciences, Graduate School of Biomedical Sciences, Nagasaki University
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