Evaluation of the Nitric Oxide Radical Scavenging Activity of Manganese Complexes of Curcumin and Its Derivative(Pharmacology)

元データ 2004-02-01 社団法人日本薬学会

概要

Curcumin manganese complex (CpCpx) and diacetylcurcumin manganese complex (AcylCpCpx) were determined as to their effect on the nitric oxide (NO) radical scavenging in vitro method using a sodium nitroprusside generating NO system compared with their parent compound and astaxanthin, an extreme antioxidant. All compounds effectively reduced the generation of NO radicals in a dose dependent manner. They exhibited strong NO radical scavenging activity with low IC_<50> values. The IC_<50> values of curcumin, diacetylcurcumin, CpCpx and AcylCpCpx obtained are 20.39±4.10 μM, 28.76±1.48μM, 9.79±1.50μM and 8.09±0.99μM, respectively. CpCpx and AcylCpCpx show greater NO radical scavenging than their parent compounds, curcumin and acetylcurcumin, respectively. However, the IC_<50> values of curcumin and related compounds were found to be less than astaxanthin, an extreme antioxidant, with the lower IC_<50> value of 3.42±0.50μM.

著者

Tohda Michihisa 和漢医薬学総合研究所 複合薬物薬理学分野
Tohda Michihisa 富山医科薬科大学和漢薬研究所
Tohda Michihisa Department Of Pharmacology Institute Of Natural Medicine Toyama Medical And Pharmaceutical Universit
Tohda Michihisa 和漢医薬学総合研究所 複合薬物薬理学
渡辺 裕司 International Research Center For Traditional Medicine Toyama Prefecture International Health Comple
Watanabe Hiroshi Department of Cardiology, Niigata City General Hospital
SUMANONT Yaowared Division of Medicinal Pharmacology, Institute of Natural Medicine, University of Toyama
VAJRAGUPTA Opa Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Mahidol University
MURAKAMI Yukihisa Department of Pharmacology, Institute of Natural Medicine, Toyama Medical and Pharmaceutical Univers
MATSUMOTO Kinzo Department of Pharmacology, Institute of Natural Medicine, Toyama Medical and Pharmaceutical Univers
Murakami Yukihisa 富山大学和漢医薬学総合研究所 複合薬物薬理学
Mukarami Yukihisa Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
Murakami Yukihisa Division Of Medicinal Pharmacology Institute Of Natural Medicine Toyama Medical And Pharmaceutical U
Murakami Yukihisa Research Institute For Wakan-yaku (traditional Sino-japanese Medicines)
Murakami Yukihisa Department Of Pharmacology Institute Of Natural Medicine:21st Century Coe Program Toyama Medical And
Vajaragupta Opa Department Of Pharmaceutical Chemistry Faculty Of Pharmacy Mahidol University
Murakami Yuko Department Of Bioactive Molecules National Institute Of Infectious Diseases
Tohda Michihisa Department Of Pharmacology Faculty Of Pharmaceutical Sciences Hokkaido University
Matsumoto Kinzo Div. Of Medicinal Pharmacology Inst. Of Natural Medicine Univ. Of Toyama
Matsumoto Kinzo Division Of Medicinal Pharmacology Institute Of Natural Medicine Toyama Medical And Pharmaceutical U
Matsumoto Kinzo Department Of Pharmacology Institute Of Natural Medicine:21st Century Coe Program Toyama Medical And
SUMANONT Yaowared Department of Pharmacology, Institute of Natural Medicine, Toyama Medical and Pharmaceutical Univers
Matsumoto K Div. Of Medicinal Pharmacology Inst. Of Natural Medicine Univ. Of Toyama
Sumanont Yaowared Division Of Medicinal Pharmacology Institute Of Natural Medicine University Of Toyama
Matsumoto Kinzo 富山大学和漢医薬学総合研究所 複合薬物薬理学
Murakami Y Department Of Bioactive Molecules National Institute Of Infectious Diseases
Murakami Y Toho Univ. Chiba Jpn
渡邉 裕司 富山医科薬科大学生物試験部門
Watanabe Hiroshi Department Of Applied Chemistry And Bioengineering Graduate School Of Engineering Osaka City Univers
Vajragupta Opa Department of Medicinal Chemistry, Faculty of Pharmacy, Mahidol University

関連論文

▼もっと見る