Corymine Potentiates NMDA-Induced Currents in Xenopus Oocytes Expressing NR1a/NR2B Glutamate Receptors
スポンサーリンク
概要
- 論文の詳細を見る
Previous studies demonstrated that corymine, an indole alkaloid isolated from the leaves of Hunter zeylanica, dose-dependently inhibited strychnine-sensitive glycine-induced currents. However, it is unclear whether this alkaloid can modulate the function of the N-methyl-<sc>D</sc>-aspartate (NMDA) receptor on which glycine acts as a co-agonist via strychnine-insensitive glycine binding sites. This study aimed to evaluate the effects of corymine on NR1a/NR2B NMDA receptors expressed in Xenopus oocytes using the two-electrode voltage clamp technique. Corymine significantly potentitated the NMDA-induced currents recorded from oocytes on days 3 and 4 after cRNA injection but it showed no effect when the current was recorded on days 5 and 6. The potentiating effect of corymine on NMDA-induced currents was induced in the presence of a low concentration of glycine (≤0.1 μM). Spermine significantly enhanced the potentiating effect of corymine observed in the oocytes on days 3 and 4, while the NMDA-receptor antagonist 2-amino-5-phosphonopentanone (AP5) and the NMDA-channel blocker 5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine (MK-801) reversed the effect of corymine. On the other hand, the nonspecific chloride channel blocker 4,4-di-isothiocyano stilbene-2,2-disulfonoc acid (DIDS) had no effect on the corymine potentiation of NMDA currents. There was no good correlation between corymine- and spermine-induced potentiation of the NMDA-current response in Xenopus oocytes. These results suggest that corymine potentiates the NMDA-induced currents by interacting with a site different from the spermine binding site.
- 社団法人 日本薬理学会の論文
- 2005-05-20
著者
-
TOHDA Michihisa
Division of Medical Pharmacology, Institute of Natural Medicine, University of Toyama
-
渡邉 裕司
富山医科薬科大学和漢薬研究所生物試験部門
-
Tohda Michihisa
和漢医薬学総合研究所 複合薬物薬理学分野
-
Tohda Michihisa
富山医科薬科大学和漢薬研究所
-
Tohda Michihisa
タイ
-
Tohda Michihisa
和漢医薬学総合研究所 複合薬物薬理学
-
MATSUMOTO Kinzo
Division of Medicinal Pharmacology, Institute of Natural Medicine, Toyama Medical and Pharmaceutical
-
渡辺 裕司
International Research Center For Traditional Medicine Toyama Prefecture International Health Comple
-
Watanabe Hiroshi
Division of Infectious Diseases, Department of Infectious Medicine, Kurume University School of Medi
-
Takayama H
Faculty Of Pharmaceutical Sciences Teikyo University
-
Takayama Hiroaki
帝京大学 薬
-
Takayama Hiroaki
Faculty Of Pharmaceutical Sciences Teikyo University
-
SOPHASAN Samaisukh
Department of Physiology, Faculty of Sciences, Mahidol University
-
高山 廣光
Graduate School Of Pharmaceutical Sciences Chiba Univ.
-
Sophasan Samaisukh
Department Of Physiology Faculty Of Science Mahidol University
-
TAKAYAMA Hiromitsu
Laboratory of Molecular Structure and Biological Function, Graduate School of Pharmaceutical Science
-
LEEWANICH Pathama
Department of Pharmacology, Faculty of Medicine, Srinakharinwirot University
-
渡邉 浩司
富山医科薬科大学和漢薬研究所生物試験部門
-
Tohda Michihisa
Division Of Medical Pharmacology Institute Of Natural Medicine University Of Toyama
-
Tohda Michihisa
Department Of Pharmacology Institute Of Natural Medicine (wakan-yaku) Toyama Medical And Pharmaceuti
-
Matsumoto Kinzo
Div. Of Medicinal Pharmacology Inst. Of Natural Medicine Univ. Of Toyama
-
Matsumoto Kinzo
Division Of Medicinal Pharmacology Institute Of Natural Medicine Toyama Medical And Pharmaceutical U
-
Matsumoto K
Div. Of Medicinal Pharmacology Inst. Of Natural Medicine Univ. Of Toyama
-
Watanabe H
Health Science University Of Hokkaido
-
Watanabe Hiroshi
Radia Industry Co. Ltd
-
Leewanich Pathama
Department Of Pharmacology Faculty Of Medicine Srinakharinwirot University
-
Takayama Hiromitsu
Laboratory Of Molecular Structure And Biological Function Graduate School Of Pharmaceutical Sciences
-
Matsumoto Kinzo
富山大学和漢医薬学総合研究所 複合薬物薬理学
-
Watanabe Hiroshi
Division Of Cardiology Niigata University Graduate School Of Medical And Dental Science
-
渡邉 裕司
富山医科薬科大学生物試験部門
-
Tohda M
Department Of Pharmacology Institute Of Natural Medicine Toyama Medical And Pharmaceutical Universit
-
Watanabe H
Division Of Medicinal Pharmacology Institute Of Natural Medicine University Of Toyama
-
東田 道久
Division Of Medicinal Pharmacology Institute Of Natural Medicine University Of Toyama
-
Watanabe Hiroshi
Biotechnology Laboratory Japan Atomic Energy Research Institute
-
Watanabe Hiroshi
Division Of Cardiology Hemotology And Endocrinology Niigata University Graduate School Of Medical And Dental Science
関連論文
- Effects of Tokishakuyakusan on the ovary in hypophysectomized rats
- Enhanced expression of BCL2/adenovirus EIB 19-kDa-interacting protein 3 mRNA, a candidate for intrinsic depression-related factor, and effects of imipramine in the frontal cortex of stressed mice
- I-074(30) 釣藤鈎アルカロイド成分リンコフィリン及びイソリンコフィリンの in vitro 海馬虚血モデルにおける神経保護作用とその機序
- P-35 一過性脳虚血誘発のマウス学習障害に対する釣藤鈎の作用
- MS-I-3 一過性脳虚血誘発のマウス学習障害に対する釣藤鈎の作用
- Effects of Tokishakuyakusan on hypothalamic pituitary adenylate cyclase-activating polypeptide (PACAP) and PACAP type I receptor (PAC_1) expression in hypophysectomized and ovariectomized rats
- Effects of Manganese Complexes of Curcumin and Diacetylcurcumin on Kainic Acid-Induced Neurotoxic Responses in the Rat Hippocampus(Pharmacology)
- Hypouricemic Effects of Acacetin and 4,5-O-Dicaffeoylquinic Acid Methyl Ester on Serum Uric Acid Levels in Potassium Oxonate-Pretreated Rats(Pharmacology)
- P-11 Eupafolin のα_2 受容体への作用 : 血圧および血管平滑筋収縮への影響
- Effects of Choto-san and Chotoko on thiopental-induced sleeping time
- A-011(31) 脳卒中易発症高血圧ラットにおける釣藤散構成生薬エキスの抗高血圧効果
- 神経分化・増殖へのセロトニン2C受容体の関与と和漢薬作用 (第14回天然薬物の開発と応用シンポジウム 講演要旨集) -- (一般講演 漢方薬の有効性の科学的解明2)
- 釣藤散の脳血管性痴呆改善効果の薬理学的裏付け (第14回天然薬物の開発と応用シンポジウム 講演要旨集) -- (シンポジウム-2 漢方薬の基礎研究から新しい臨床研究への展開)
- 両側総頚動脈永久結紮による中枢神経の進行性障害及び脳内ACh含量の変化
- 一過性虚血及び抗コリン薬スコポラミン誘発の学習障害に対する四物湯の改善作用及び処方解析
- スコポラミン誘発のマウス学習行動障害に対する四物湯及び構成生薬の影響 : 産婦・中枢神経系
- 生薬資源の生産と品質管理
- Panax ginseng Extract Improves the Scopolamine-Induced Disruption of 8-Arm Radial Maze Performance in Rats
- Panax ginseng Extract Improves the Performance of Aged Fischer 344 Rats in Radial Maze Task but Not in Operant Brightness Discrimination Task
- Analysis of Resonance Transitions in X-Ray Spectra of Electron Interaction with Highly Charged Iron Ions
- Analysis of Dielectronic Recombination Transitions for Highly Charged Iron Ions
- Corymine Potentiates NMDA-Induced Currents in Xenopus Oocytes Expressing NR1a/NR2B Glutamate Receptors
- Enhanced Expression of BCL2/Adenovirus EIB 19-kDa-Interacting Protein 3 mRNA, a Candidate for Intrinsic Depression-Related Factor, and Effects of Imipramine in the Frontal Cortex of Stressed Mice
- P-01 補中益気湯長期間処置によるNG108-15細胞の遺伝子発現変化(脳神経・精神,一般演題ポスター,第24回和漢医薬学会大会 和漢薬の複雑さ-経験知と科学知-)
- The mRNA Expression Differences of RNA Editing Enzymes in Differentiated and Undifferentiated NG108-15 Cells
- Effects of Choto-san and Its Related Constituents on Endogenous Antioxidant Systems(Pharmacology)
- RNA Editing and Short Variant of Serotonin 2C Receptor mRNA in Neuronally Differentiated NG108-15 Cells
- Antioxidant and Free Radical-Scavenging Activity of Choto-san and Its Related Constituents(Pharmacology)
- Chronic Treatment With Imipramine Inhibits Cell Growth and Enhances Serotonin 2C Receptor mRNA Expression in NG 108-15 Cells
- Inhibition in a microgravity environment of the recovery of Escherichia coli cells damaged by heavy ion beams during the NASDA ISS Phase I Program of NASA Shuttle/Mir Mission No. 6
- Effects of Hochu-ekki-to (Bu-Zhong-Yi-Qi-Tang), a Kampo medicine on serotonin 2C subtype receptor-evoked current response and the receptor mRNA expression
- Radiation response mechanisms of the extremely radioresistant bacterium Deinococcus radiodurans
- Characterization of RecA424 and RecA670 Proteins from Deinococcus radiodurans
- The Characterization of Deinococcus radiodurans RecA424 and RecA670 Proteins
- DNA Repair-promoting Protein from Deinococcus radiodurans
- 脳血管性認知症病態モデルにおける漢方薬「釣藤散」の薬理作用とその機序
- 複合薬物薬理学分野(病態制御部門,各部門・附属センターの活動と業績)
- 複合薬物薬理学分野(病態制御部門,各部門・附属センターの活動と業績)
- 生物試験分野(各部門・附属センターの活動と業績)
- 自然発症高血圧ラットにおける釣藤散の抗高血圧作用 : 釣藤鈎及び石膏の役割について
- P-29 釣藤鈎フェノール分画及び成分の降圧, 脳虚血予防作用
- 生物試験部門
- 釣藤散,釣藤鈎及びそのアルカロイド成分の脳虚血予防作用 : マウス水迷路学習行動を指標として
- P-6 自然発症高血圧ラットの血圧に対する釣藤鈎メタノールエキスおよびそのフェノール成分の作用
- P-5 自然発症高血圧ラットにおける釣藤散の降圧作用
- Investigation on traditional medicine in Myanmar and Vietnam
- Inhibitory Effects of Corymine-Related Compounds on Glycine Receptors Expressed in Xenopus Oocytes
- タイ薬用植物成分 mitragynine の抗侵害受容作用に関与するオピオイド受容体サブタイプ
- Effects of Mitragynine on cAMP Formation Mediated by δ-Opiate Receptors in NG108-15 Cells
- Behavioral Studies on Alkaloids Extracted from the Leaves of Hunteria zeylanica
- Inhibitory Effect of Alkaloids Extracted from the Stem Bark of Hunteria zeylanica on 5-Lipoxygenase Activity in Vitro
- Heavy-Ion Microbeam System at JAEA-Takasaki for Microbeam Biology
- Why Does Hemocyte Density Rise during the Wandering Stage of the Silkworm, Bombyx mori?
- Regeneration of Hemopoietic Organs in the Silkworm, Bombyx mori, After Locally Targeted Irradiation with Heavy Ion Beams
- Cloning of Structural Gene of Deinococcus radiodurans UV-Endonuclease β(Biochemistry & Molecular Biology)
- Effects of Heavy-ion Radiosurgery on the Hemopoietic Function of the Silkworm Bombyx mori
- Radiosurgery applications of the local irradiation by heavy ion beams : Decrease of antibacterial activity ofhemolymph after local irradiation on the hemopoietic organs of larvae of silkworm, Bomyx mori
- Cell Irradiation System with a Single or Precise Numbers of Heavy Ions using a Collimated Heavy Ion Microbeamat TIARA, JAERI Takasaki
- Recovery of Deinococcus radiodurans from radiation damage was enhanced under microgravity
- Permanent Occlusion of Bilateral Internal Carotid Arteries Produces Cognitive Deficits in Two Learning Behavior Tasks
- Tetramethylpyrazine Improves Spatial Cognitive Impairment Induced by Permanent Occlusion of Bilateral Common Carotid Arteries or Scopolamine in Rats
- 桂アルデヒドの中枢作用
- Anti-hypertensive and anti-stroke effects of Chrysanthemum extracts in stroke-prone spontaneously hypertensive rats
- Imipramine-induced increase in 5-HT2C receptor mRNA level in the rat brain
- Possible Involvement of Signal Transducers and Activators of Transcription 3 System on Depression in the Model Mice Brain
- Chotosan Enhances Macrophage Colony-Stimulating Factor mRNA Expression in the Ischemic Rat Brain and C6Bu-1 Glioma Cells(Biochemistry)
- Chotosan, a Kampo Formula, Ameliorates Chronic Cerebral Hypoperfusion-Induced Deficits in Object Recognition Behaviors and Central Cholinergic Systems in Mice
- Preventive Effect of Chotosan, a Kampo Medicine, on Transient Ischemia-Induced Learning Deficit Is Mediated by Stimulation of Muscarinic M_1 But Not Nicotinic Receptor(Pharmacology)
- Social Isolation Stress-Induced Oxidative Damage in Mouse Brain and Its Modulation by Majonoside-R2, a Vietnamese Ginseng Saponin(Pharmacology)
- The Effects of Choto-san on the mRNA Expression of Alzheimer's Disease Related Factors in the Permanent Ischemic Rat Brain(Pharmacology)
- 脳虚血誘発のマウス空間認知障害に対する釣藤散の効果 (第15回天然薬物の開発と応用シンポジウム講演要旨集) -- (一般講演)
- Expression Changes of the mRNA of Alzheimer's Disease Related Factors in the Permanent Ischemic Rat Brain(Pharmacology)
- DNA array analysis of gene expression changes by Choto-san in the ischemic rat brain
- Evaluation of the Nitric Oxide Radical Scavenging Activity of Manganese Complexes of Curcumin and Its Derivative(Pharmacology)
- Serotonin 2C Receptor (5-HT2CR) mRNA Editing–Induced Down-Regulation of 5-HT2CR Function in Xenopus Oocytes: the Significance of Site C Editing
- Berberine Exerts Neuroprotective Actions against in Vitro Ischemia-Induced Neuronal Cell Damage in Organotypic Hippocampal Slice Cultures : Involvement of B-Cell Lymphoma 2 Phosphorylation Suppression(Pharmacology)
- Cytoprotective and Cytotoxic Effects of Curcumin : Dual Action on H_2O_2-Induced Oxidative Cell Damage in NG108-15 Cells
- Protective effect of Choto-san and its related constituents on hydrogen peroxide-induced cell damage in NG108-15 cells
- Ameliorative Effects of Paeoniflorin, a Major Constituent of Peony Root, on Adenosine A_1 Receptor-Mediated Impairment of Passive Avoidance Performance and Long-Term Potentiation in the Hippocampus
- Diazepam binding inhibitor (DBI) gene expression in the brains of socially isolated and group-housed mice
- Antihypertensive Potential and Mechanism of Action of Astaxanthin : III. Antioxidant and Histopathological Effects in Spontaneously Hypertensive Rats(Pharmacology)
- Antihypertensive Potential and Mechanism of Action of Astaxanthin : II. Vascular Reactivity and Hemorheology in Spontaneously Hypertensive Rats(Pharmacology)
- Developmental Changes in Serotonin 2C Receptor mRNA Editing in the Rat Cerebral Cortex and Primary Cultured Cortical Neurons(Pharmacology)
- The Possible Involvement of GABA_A Systems in the Antinarcotic Effect of Majonoside-R2, a Major Constituent of Vietnamese Ginseng, in Mice
- P-64 Type II コラーゲン誘導性関節炎に対する「補中益気湯」の有効性と免疫調節作用の検討
- P-19 長期隔離飼育マウスのペントバルビタール誘発睡眠と闘争行動に対する四物湯及びその構成生薬の作用
- The mRNA Expression of Serotonin 2C Subtype Receptors Uncoupled With Inositol Hydrolysis in NG108-15 Cells
- 日本学術振興会の拠点大学方式による学術交流事業
- Studies on the Activation Mechanisms of Guanylyl Cyclase by Serotonin, Probably through a Novel Subtype of Serotonin Receptor (5-HT_)
- P-21 フラボノイドの一種 Eupafolin の一般薬理ならびに生化学的薬理作用の研究
- P-18 慢性脳虚血ラットの学習行動障害に対する四物湯の影響
- Facilitatory and Inhibitory Effects of Harmaline on the Tryptophan- Induced 5-Hydroxytryptamine Syndrome and Body Temperature Changes in Pargyline-Pretreated Rats
- 108) 黄〓エキス並びに黄〓関連フラボノイドの神経細胞受容体 : アデニル酸シクラーゼ系への作用
- Neuropharmacological Actions of Pluchea indica LESS Root Extract in Socially Isolated Mice
- Serotonin 2C Receptor (5-HT2CR) mRNA Editing-Induced Down-Regulation of 5-HT2CR Function in Xenopus Oocytes : the Significance of Site C Editing
- 漢方方剤の中枢薬理作用の研究
- P-50 補中益気湯によるセロトニン 2C mRNA 発現促進作用
- 抗うつ薬連投によるセロトニン2C受容体mRNA発現
- P-E-2 フラボノイドの薬理作用、特に細胞情報伝達系への作用
- 富山医科薬科大学和漢薬研究所生物試験部門