Expression Changes of the mRNA of Alzheimer's Disease Related Factors in the Permanent Ischemic Rat Brain(Pharmacology)
スポンサーリンク
概要
- 論文の詳細を見る
The rat with permanent occlusion of the bilateral common carotid arteries (2VO) is useful model for the study of dementia. The expression changes of amyloid precursor protein (APP), secretase, α7 nicotinic acetylcholine receptor (α7NicR) and acetylcholine esterase (AChE), which are involved in Alzheimer's disease, were examined by quantitative RT/PCR in this model rat brain. The expression of APP, α7NicR and secretase were increased 4 d after 2VO. The α7NicR level at 2 d after operation already tended to increase. These result suggest that α7NicR expression was enhanced at early stage of brain ischemia. Using this model to find drugs which regulate the α7NicR expression will be useful to assay the materials with anti-dementive effect.
- 社団法人日本薬学会の論文
- 2004-12-01
著者
-
渡邉 裕司
富山医科薬科大学和漢薬研究所生物試験部門
-
Tohda Michihisa
和漢医薬学総合研究所 複合薬物薬理学分野
-
Tohda Michihisa
富山医科薬科大学和漢薬研究所
-
Tohda Michihisa
タイ
-
Tohda Michihisa
Department Of Pharmacology Institute Of Natural Medicine Toyama Medical And Pharmaceutical Universit
-
Tohda Michihisa
和漢医薬学総合研究所 複合薬物薬理学
-
渡辺 裕司
International Research Center For Traditional Medicine Toyama Prefecture International Health Comple
-
Hayashi Hisae
富山医科薬科大学和漢薬研究所
-
Hayashi Hisae
Division Of Medicinal Pharmacology Institute Of Natural Medicine Toyama Medical And Pharmaceutical U
-
Watanabe Hiroshi
Department of Cardiology, Niigata City General Hospital
-
JEENAPONGSA Rattima
Department of Pharmacology, Institute of Natural Medicine, Toyama Medical and Pharmaceutical Univers
-
MATSUMOTO Kinzo
Department of Pharmacology, Institute of Natural Medicine, Toyama Medical and Pharmaceutical Univers
-
HAYASHI Hideyuki
Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido
-
渡邉 浩司
富山医科薬科大学和漢薬研究所生物試験部門
-
HAYASHI HISAE
Department of Cardiovascular Surgery, Tokyo Women's Medical College
-
Tohda Michihisa
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Hokkaido University
-
Tohda Michihisa
Department Of Pharmacology Institute Of Natural Medicine (wakan-yaku) Toyama Medical And Pharmaceuti
-
Matsumoto Kinzo
Div. Of Medicinal Pharmacology Inst. Of Natural Medicine Univ. Of Toyama
-
Matsumoto Kinzo
Division Of Medicinal Pharmacology Institute Of Natural Medicine Toyama Medical And Pharmaceutical U
-
Matsumoto Kinzo
Department Of Pharmacology Institute Of Natural Medicine:21st Century Coe Program Toyama Medical And
-
SUWANAKITCH Prawpan
Department of Pharmacology, Institute of Natural Medicine, Toyama Medical and Pharmaceutical Univers
-
Matsumoto K
Div. Of Medicinal Pharmacology Inst. Of Natural Medicine Univ. Of Toyama
-
Watanabe H
Health Science University Of Hokkaido
-
Watanabe Hiroshi
Radia Industry Co. Ltd
-
Jeenapongsa Rattima
Department Of Pharmacology Institute Of Natural Medicine Toyama Medical And Pharmaceutical Universit
-
Matsumoto Kinzo
富山大学和漢医薬学総合研究所 複合薬物薬理学
-
Hayashi H
Division Of Medicinal Pharmacology Institute Of Natural Medicine Toyama Medical And Pharmaceutical U
-
渡邉 裕司
富山医科薬科大学生物試験部門
-
Tohda M
Department Of Pharmacology Institute Of Natural Medicine Toyama Medical And Pharmaceutical Universit
-
東田 道久
Division Of Medicinal Pharmacology Institute Of Natural Medicine University Of Toyama
-
Watanabe Hiroshi
Biotechnology Laboratory Japan Atomic Energy Research Institute
-
Suwanakitch Prawpan
Department Of Pharmacology Institute Of Natural Medicine Toyama Medical And Pharmaceutical Universit
-
Watanabe Hiroshi
Department Of Applied Chemistry And Bioengineering Graduate School Of Engineering Osaka City Univers
関連論文
- Enhanced expression of BCL2/adenovirus EIB 19-kDa-interacting protein 3 mRNA, a candidate for intrinsic depression-related factor, and effects of imipramine in the frontal cortex of stressed mice
- I-074(30) 釣藤鈎アルカロイド成分リンコフィリン及びイソリンコフィリンの in vitro 海馬虚血モデルにおける神経保護作用とその機序
- P-35 一過性脳虚血誘発のマウス学習障害に対する釣藤鈎の作用
- MS-I-3 一過性脳虚血誘発のマウス学習障害に対する釣藤鈎の作用
- Effects of Manganese Complexes of Curcumin and Diacetylcurcumin on Kainic Acid-Induced Neurotoxic Responses in the Rat Hippocampus(Pharmacology)
- P-11 Eupafolin のα_2 受容体への作用 : 血圧および血管平滑筋収縮への影響
- Effects of Choto-san and Chotoko on thiopental-induced sleeping time
- A-011(31) 脳卒中易発症高血圧ラットにおける釣藤散構成生薬エキスの抗高血圧効果
- 神経分化・増殖へのセロトニン2C受容体の関与と和漢薬作用 (第14回天然薬物の開発と応用シンポジウム 講演要旨集) -- (一般講演 漢方薬の有効性の科学的解明2)
- 釣藤散の脳血管性痴呆改善効果の薬理学的裏付け (第14回天然薬物の開発と応用シンポジウム 講演要旨集) -- (シンポジウム-2 漢方薬の基礎研究から新しい臨床研究への展開)
- 両側総頚動脈永久結紮による中枢神経の進行性障害及び脳内ACh含量の変化
- 一過性虚血及び抗コリン薬スコポラミン誘発の学習障害に対する四物湯の改善作用及び処方解析
- スコポラミン誘発のマウス学習行動障害に対する四物湯及び構成生薬の影響 : 産婦・中枢神経系
- 生薬資源の生産と品質管理
- Panax ginseng Extract Improves the Scopolamine-Induced Disruption of 8-Arm Radial Maze Performance in Rats
- Panax ginseng Extract Improves the Performance of Aged Fischer 344 Rats in Radial Maze Task but Not in Operant Brightness Discrimination Task
- D-1 老齢ラットの学習行動障害に対する薬用人参の作用
- Analysis of Resonance Transitions in X-Ray Spectra of Electron Interaction with Highly Charged Iron Ions
- Analysis of Dielectronic Recombination Transitions for Highly Charged Iron Ions
- Corymine Potentiates NMDA-Induced Currents in Xenopus Oocytes Expressing NR1a/NR2B Glutamate Receptors
- P-01 補中益気湯長期間処置によるNG108-15細胞の遺伝子発現変化(脳神経・精神,一般演題ポスター,第24回和漢医薬学会大会 和漢薬の複雑さ-経験知と科学知-)
- The mRNA Expression Differences of RNA Editing Enzymes in Differentiated and Undifferentiated NG108-15 Cells
- Effects of Choto-san and Its Related Constituents on Endogenous Antioxidant Systems(Pharmacology)
- RNA Editing and Short Variant of Serotonin 2C Receptor mRNA in Neuronally Differentiated NG108-15 Cells
- Antioxidant and Free Radical-Scavenging Activity of Choto-san and Its Related Constituents(Pharmacology)
- RNA Editing and Short Variant of Serotonin 2C Receptor mRNA in Neuronally Differentiated NG108-15 Cells
- Chronic Treatment With Imipramine Inhibits Cell Growth and Enhances Serotonin 2C Receptor mRNA Expression in NG 108-15 Cells
- Inhibition in a microgravity environment of the recovery of Escherichia coli cells damaged by heavy ion beams during the NASDA ISS Phase I Program of NASA Shuttle/Mir Mission No. 6
- Effects of Hochu-ekki-to (Bu-Zhong-Yi-Qi-Tang), a Kampo medicine on serotonin 2C subtype receptor-evoked current response and the receptor mRNA expression
- Radiation response mechanisms of the extremely radioresistant bacterium Deinococcus radiodurans
- Characterization of RecA424 and RecA670 Proteins from Deinococcus radiodurans
- The Characterization of Deinococcus radiodurans RecA424 and RecA670 Proteins
- DNA Repair-promoting Protein from Deinococcus radiodurans
- 脳血管性認知症病態モデルにおける漢方薬「釣藤散」の薬理作用とその機序
- 複合薬物薬理学分野(病態制御部門,各部門・附属センターの活動と業績)
- 複合薬物薬理学分野(病態制御部門,各部門・附属センターの活動と業績)
- 生物試験分野(各部門・附属センターの活動と業績)
- 自然発症高血圧ラットにおける釣藤散の抗高血圧作用 : 釣藤鈎及び石膏の役割について
- P-29 釣藤鈎フェノール分画及び成分の降圧, 脳虚血予防作用
- 生物試験部門
- 釣藤散,釣藤鈎及びそのアルカロイド成分の脳虚血予防作用 : マウス水迷路学習行動を指標として
- P-6 自然発症高血圧ラットの血圧に対する釣藤鈎メタノールエキスおよびそのフェノール成分の作用
- P-5 自然発症高血圧ラットにおける釣藤散の降圧作用
- P-13 両側総頸動脈永久結紮ラットの学習行動に対する薬用人参及びタクリンの影響
- Investigation on traditional medicine in Myanmar and Vietnam
- [総合ディスカッション] (現代社会のストレスと漢方の役割)
- 現代社会のストレスと漢方の役割
- 漢方薬の効果発現と臨床応用
- Inhibitory Effects of Corymine-Related Compounds on Glycine Receptors Expressed in Xenopus Oocytes
- タイ薬用植物成分 mitragynine の抗侵害受容作用に関与するオピオイド受容体サブタイプ
- Effects of Mitragynine on cAMP Formation Mediated by δ-Opiate Receptors in NG108-15 Cells
- Behavioral Studies on Alkaloids Extracted from the Leaves of Hunteria zeylanica
- Inhibitory Effect of Alkaloids Extracted from the Stem Bark of Hunteria zeylanica on 5-Lipoxygenase Activity in Vitro
- Effects of Alkaloids Extracted from the Stem Bark of Hunteria zeylanica on Acute Inflammation in Experimental Animals
- Heavy-Ion Microbeam System at JAEA-Takasaki for Microbeam Biology
- Why Does Hemocyte Density Rise during the Wandering Stage of the Silkworm, Bombyx mori?
- Regeneration of Hemopoietic Organs in the Silkworm, Bombyx mori, After Locally Targeted Irradiation with Heavy Ion Beams
- Cloning of Structural Gene of Deinococcus radiodurans UV-Endonuclease β(Biochemistry & Molecular Biology)
- Effects of Heavy-ion Radiosurgery on the Hemopoietic Function of the Silkworm Bombyx mori
- Radiosurgery applications of the local irradiation by heavy ion beams : Decrease of antibacterial activity ofhemolymph after local irradiation on the hemopoietic organs of larvae of silkworm, Bomyx mori
- Cell Irradiation System with a Single or Precise Numbers of Heavy Ions using a Collimated Heavy Ion Microbeamat TIARA, JAERI Takasaki
- Recovery of Deinococcus radiodurans from radiation damage was enhanced under microgravity
- II-B-6 前脳基底核破壊ラットの明暗弁別学習障害に対する paeoniflorin の作用
- Permanent Occlusion of Bilateral Internal Carotid Arteries Produces Cognitive Deficits in Two Learning Behavior Tasks
- 桂アルデヒドの中枢作用
- Possible Involvement of Signal Transducers and Activators of Transcription 3 System on Depression in the Model Mice Brain
- Chotosan Enhances Macrophage Colony-Stimulating Factor mRNA Expression in the Ischemic Rat Brain and C6Bu-1 Glioma Cells(Biochemistry)
- Chotosan, a Kampo Formula, Ameliorates Chronic Cerebral Hypoperfusion-Induced Deficits in Object Recognition Behaviors and Central Cholinergic Systems in Mice
- Preventive Effect of Chotosan, a Kampo Medicine, on Transient Ischemia-Induced Learning Deficit Is Mediated by Stimulation of Muscarinic M_1 But Not Nicotinic Receptor(Pharmacology)
- Social Isolation Stress-Induced Oxidative Damage in Mouse Brain and Its Modulation by Majonoside-R2, a Vietnamese Ginseng Saponin(Pharmacology)
- The Effects of Choto-san on the mRNA Expression of Alzheimer's Disease Related Factors in the Permanent Ischemic Rat Brain(Pharmacology)
- 脳虚血誘発のマウス空間認知障害に対する釣藤散の効果 (第15回天然薬物の開発と応用シンポジウム講演要旨集) -- (一般講演)
- Expression Changes of the mRNA of Alzheimer's Disease Related Factors in the Permanent Ischemic Rat Brain(Pharmacology)
- DNA array analysis of gene expression changes by Choto-san in the ischemic rat brain
- Evaluation of the Nitric Oxide Radical Scavenging Activity of Manganese Complexes of Curcumin and Its Derivative(Pharmacology)
- Serotonin 2C Receptor (5-HT2CR) mRNA Editing–Induced Down-Regulation of 5-HT2CR Function in Xenopus Oocytes: the Significance of Site C Editing
- Cytoprotective and Cytotoxic Effects of Curcumin : Dual Action on H_2O_2-Induced Oxidative Cell Damage in NG108-15 Cells
- Protective effect of Choto-san and its related constituents on hydrogen peroxide-induced cell damage in NG108-15 cells
- Ameliorative Effects of Paeoniflorin, a Major Constituent of Peony Root, on Adenosine A_1 Receptor-Mediated Impairment of Passive Avoidance Performance and Long-Term Potentiation in the Hippocampus
- Diazepam binding inhibitor (DBI) gene expression in the brains of socially isolated and group-housed mice
- Uptake of Liposomally Entrapped Fluorescent Antisense Oligonucleotides in NG108-15 Cells : Conventional versus pH-Sensitive
- Influence of Chronic Treatment With Imipramine on mRNA Levels in Rat Brain : Elevation of Glyceraldehyde-3-phosphate Dehydrogenase Levels
- Enhancement of Serotonin 2C Receptor mRNA Expression by Antidepressants Possessing the Receptor-Blocking Activity in the Rat Brain
- Molecular Cloning and Characterization of a Novel Sequence, vof-16, with Enhanced Expression in Permanent Ischemic Rat Brain(Pharmacology)
- Influence of Aging on Rolipram-Sensitive Phosphodiesterase Activity and [^3H] Rolipram Binding in the Rat Brain
- P-64 Type II コラーゲン誘導性関節炎に対する「補中益気湯」の有効性と免疫調節作用の検討
- P-19 長期隔離飼育マウスのペントバルビタール誘発睡眠と闘争行動に対する四物湯及びその構成生薬の作用
- The mRNA Expression of Serotonin 2C Subtype Receptors Uncoupled With Inositol Hydrolysis in NG108-15 Cells
- 日本学術振興会の拠点大学方式による学術交流事業
- Studies on the Activation Mechanisms of Guanylyl Cyclase by Serotonin, Probably through a Novel Subtype of Serotonin Receptor (5-HT_)
- P-21 フラボノイドの一種 Eupafolin の一般薬理ならびに生化学的薬理作用の研究
- P-18 慢性脳虚血ラットの学習行動障害に対する四物湯の影響
- 108) 黄〓エキス並びに黄〓関連フラボノイドの神経細胞受容体 : アデニル酸シクラーゼ系への作用
- Neuropharmacological Actions of Pluchea indica LESS Root Extract in Socially Isolated Mice
- Serotonin 2C Receptor (5-HT2CR) mRNA Editing-Induced Down-Regulation of 5-HT2CR Function in Xenopus Oocytes : the Significance of Site C Editing
- 漢方方剤の中枢薬理作用の研究
- P-50 補中益気湯によるセロトニン 2C mRNA 発現促進作用
- 抗うつ薬連投によるセロトニン2C受容体mRNA発現
- P-E-2 フラボノイドの薬理作用、特に細胞情報伝達系への作用
- 富山医科薬科大学和漢薬研究所生物試験部門