Expression Changes of the mRNA of Alzheimer's Disease Related Factors in the Permanent Ischemic Rat Brain(Pharmacology)

元データ 2004-12-01 社団法人日本薬学会

概要

The rat with permanent occlusion of the bilateral common carotid arteries (2VO) is useful model for the study of dementia. The expression changes of amyloid precursor protein (APP), secretase, α7 nicotinic acetylcholine receptor (α7NicR) and acetylcholine esterase (AChE), which are involved in Alzheimer's disease, were examined by quantitative RT/PCR in this model rat brain. The expression of APP, α7NicR and secretase were increased 4 d after 2VO. The α7NicR level at 2 d after operation already tended to increase. These result suggest that α7NicR expression was enhanced at early stage of brain ischemia. Using this model to find drugs which regulate the α7NicR expression will be useful to assay the materials with anti-dementive effect.

著者

渡邉 裕司 富山医科薬科大学和漢薬研究所生物試験部門
Tohda Michihisa 和漢医薬学総合研究所 複合薬物薬理学分野
Tohda Michihisa 富山医科薬科大学和漢薬研究所
Tohda Michihisa Department Of Pharmacology Institute Of Natural Medicine Toyama Medical And Pharmaceutical Universit
Tohda Michihisa 和漢医薬学総合研究所 複合薬物薬理学
渡辺 裕司 International Research Center For Traditional Medicine Toyama Prefecture International Health Comple
Hayashi Hisae 富山医科薬科大学和漢薬研究所
Hayashi Hisae Division Of Medicinal Pharmacology Institute Of Natural Medicine Toyama Medical And Pharmaceutical U
Watanabe Hiroshi Department of Cardiology, Niigata City General Hospital
JEENAPONGSA Rattima Department of Pharmacology, Institute of Natural Medicine, Toyama Medical and Pharmaceutical Univers
MATSUMOTO Kinzo Department of Pharmacology, Institute of Natural Medicine, Toyama Medical and Pharmaceutical Univers
HAYASHI Hideyuki Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido
渡邉 浩司 富山医科薬科大学和漢薬研究所生物試験部門
HAYASHI HISAE Department of Cardiovascular Surgery, Tokyo Women's Medical College
Tohda Michihisa Department Of Pharmacology Faculty Of Pharmaceutical Sciences Hokkaido University
Tohda Michihisa Department Of Pharmacology Institute Of Natural Medicine (wakan-yaku) Toyama Medical And Pharmaceuti
Matsumoto Kinzo Div. Of Medicinal Pharmacology Inst. Of Natural Medicine Univ. Of Toyama
Matsumoto Kinzo Division Of Medicinal Pharmacology Institute Of Natural Medicine Toyama Medical And Pharmaceutical U
Matsumoto Kinzo Department Of Pharmacology Institute Of Natural Medicine:21st Century Coe Program Toyama Medical And
SUWANAKITCH Prawpan Department of Pharmacology, Institute of Natural Medicine, Toyama Medical and Pharmaceutical Univers
Matsumoto K Div. Of Medicinal Pharmacology Inst. Of Natural Medicine Univ. Of Toyama
Watanabe H Health Science University Of Hokkaido
Watanabe Hiroshi Radia Industry Co. Ltd
Jeenapongsa Rattima Department Of Pharmacology Institute Of Natural Medicine Toyama Medical And Pharmaceutical Universit
Matsumoto Kinzo 富山大学和漢医薬学総合研究所 複合薬物薬理学
Hayashi H Division Of Medicinal Pharmacology Institute Of Natural Medicine Toyama Medical And Pharmaceutical U
渡邉 裕司 富山医科薬科大学生物試験部門
Tohda M Department Of Pharmacology Institute Of Natural Medicine Toyama Medical And Pharmaceutical Universit
東田 道久 Division Of Medicinal Pharmacology Institute Of Natural Medicine University Of Toyama
Watanabe Hiroshi Biotechnology Laboratory Japan Atomic Energy Research Institute
Suwanakitch Prawpan Department Of Pharmacology Institute Of Natural Medicine Toyama Medical And Pharmaceutical Universit
Watanabe Hiroshi Department Of Applied Chemistry And Bioengineering Graduate School Of Engineering Osaka City Univers

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