Chotosan, a Kampo Formula, Ameliorates Chronic Cerebral Hypoperfusion-Induced Deficits in Object Recognition Behaviors and Central Cholinergic Systems in Mice

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概要

• 論文の詳細を見る

• We previously demonstrated that the Kampo formula chotosan (CTS) ameliorated spatial cognitive impairment via central cholinergic systems in a chronic cerebral hypoperfusion (P2VO) mouse model. In this study, the object discrimination tasks were used to determine if the ameliorative effects of CTS on P2VO-induced cognitive deficits are a characteristic pharmacological profile of this formula, with the aim of clarifying the mechanisms by which CTS enhances central cholinergic function in P2VO mice. The cholinesterase inhibitor tacrine (THA) and Kampo formula saikokeishito (SKT) were used as controls. P2VO impaired object discrimination performance in the object recognition, location, and context tests. Daily administration of CTS (750 mg/kg, p.o.) and THA (2.5 mg/kg, i.p.) improved the object discrimination deficits, whereas SKT (750 mg/kg, p.o.) did not. In ex vivo assays, tacrine but not CTS or SKT inhibited cortical cholinesterase activity. P2VO reduced the mRNA expression of m3 and m5 muscarinic receptors and choline acetyltransferase but not that of other muscarinic receptor subtypes in the cerebral cortex. Daily administration of CTS and THA but not SKT reversed these expression changes. These results suggest that CTS and THA improve P2VO-induced cognitive impairment by normalizing the deficit of central cholinergic systems and that the beneficial effect on P2VO-induced cognitive deficits is a distinctive pharmacological characteristic of CTS.

• 社団法人 日本薬理学会の論文
• 2007-04-20

著者

• TOHDA Michihisa

  Division of Medical Pharmacology, Institute of Natural Medicine, University of Toyama

• 渡邉 裕司

  富山医科薬科大学和漢薬研究所生物試験部門

• Tohda Michihisa

  和漢医薬学総合研究所 複合薬物薬理学分野

• Tohda Michihisa

  富山医科薬科大学和漢薬研究所

• Tohda Michihisa

  タイ

• Tohda Michihisa

  和漢医薬学総合研究所 複合薬物薬理学

• MURAKAMI Yukihisa

  Division of Medicinal Pharmacology, Institute of Natural Medicine, Toyama Medical and Pharmaceutical

• MATSUMOTO Kinzo

  Division of Medicinal Pharmacology, Institute of Natural Medicine, Toyama Medical and Pharmaceutical

• 渡辺 裕司

  International Research Center For Traditional Medicine Toyama Prefecture International Health Comple

• Murakami Yukihisa

  富山大学和漢医薬学総合研究所 複合薬物薬理学

• Mukarami Yukihisa

  Institute Of Natural Medicine Toyama Medical And Pharmaceutical University

• Murakami Yukihisa

  Division Of Medicinal Pharmacology Institute Of Natural Medicine Toyama Medical And Pharmaceutical U

• Murakami Yukihisa

  Research Institute For Wakan-yaku (traditional Sino-japanese Medicines)

• SHIMADA Yutaka

  Department of Japanese Oriental Medicine, Faculty of Medicine, Toyama Medical and Pharmaceutical Uni

• 渡邉 浩司

  富山医科薬科大学和漢薬研究所生物試験部門

• Obi Ryosuke

  Department of Japanese Oriental Medicine, Toyama Medical and Pharmaceutical University

• Shimada Y

  Tokyo Inst. Technol. Yokohama Jpn

• Murakami Yuko

  Department Of Bioactive Molecules National Institute Of Infectious Diseases

• Tohda Michihisa

  Division Of Medical Pharmacology Institute Of Natural Medicine University Of Toyama

• Tohda Michihisa

  Department Of Pharmacology Institute Of Natural Medicine (wakan-yaku) Toyama Medical And Pharmaceuti

• Matsumoto Kinzo

  Div. Of Medicinal Pharmacology Inst. Of Natural Medicine Univ. Of Toyama

• Matsumoto Kinzo

  Division Of Medicinal Pharmacology Institute Of Natural Medicine Toyama Medical And Pharmaceutical U

• Shimada Yuji

  Microsystem Research Center Precision And Intelligence Laboratory Tokyo Institute Of Technology

• ZHAO Qi

  Division of Medicinal Pharmacology, Institute of Natural Medicine,University of Toyama

• Shimada Y

  Tohoku Univ. Sendai Jpn

• Matsumoto K

  Div. Of Medicinal Pharmacology Inst. Of Natural Medicine Univ. Of Toyama

• Zhao Qi

  Division Of Medicinal Pharmacology Institute Of Natural Medicine University Of Toyama

• Zhao Qi

  Division Of Pharmacology Institute Of Natural Medicine Toyama Medical & Pharmaceutical Universit

• Watanabe H

  Health Science University Of Hokkaido

• 嶋田 豊

  富山医科薬科大学医学部和漢診療学

• Watanabe Hiroshi

  Radia Industry Co. Ltd

• Matsumoto Kinzo

  富山大学和漢医薬学総合研究所 複合薬物薬理学

• Murakami Y

  Department Of Bioactive Molecules National Institute Of Infectious Diseases

• Obi Ryosuke

  Division Of Medicinal Pharmacology Institute Of Natural Medicine University Of Toyama:department Of

• Obi Ryosuke

  Department Of Japanese Oriental Medicine Graduate School Of Medical And Pharmaceutical Sciences Univ

• Murakami Y

  Toho Univ. Chiba Jpn

• 渡邉 裕司

  富山医科薬科大学生物試験部門

• Tohda M

  Department Of Pharmacology Institute Of Natural Medicine Toyama Medical And Pharmaceutical Universit

• 島田 洋蔵

  Dept. Of Japanese Oriental Medicine Faculty Of Medicine University Of Toyama

• Shimada Yutaka

  Department Of Anatomy And Cell Biology School Of Medicine Chiba Unversity

• Shimada Yutaka

  Department Of Japanese Oriental Medicine Faculty Of Medicine

• Shimada Yutaka

  21^<st> Century Coe Program Toyama Medical And Pharmaceutical University

• 東田 道久

  Division Of Medicinal Pharmacology Institute Of Natural Medicine University Of Toyama

• Watanabe Hiroshi

  Biotechnology Laboratory Japan Atomic Energy Research Institute

• Shimada Yutaka

  Department Of Anatomy And Cell Biology School Of Medicine Chiba University

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