Panax ginseng Extract Improves the Performance of Aged Fischer 344 Rats in Radial Maze Task but Not in Operant Brightness Discrimination Task
スポンサーリンク
概要
- 論文の詳細を見る
The effect of Panax ginseng extract on the learning performance of aged Fischer 344 rats using the 8-arm radial maze task and the operant discrimination task was examined. Aged rats showed significantly impaired learning performance in both tasks. Daily administration of ginseng extract (8g/kg/d, p. o. for 12-33 d) ameliorated the impairment of learning performance in the radial maze task but not in the operant discrimination task. These results suggest that subchronic treatment with ginseng extract improves spatial cognitive impairment in aged rats.
- 社団法人日本薬学会の論文
- 1995-09-15
著者
-
清水 岑夫
富山医科薬科大学薬学部
-
渡辺 裕司
International Research Center For Traditional Medicine Toyama Prefecture International Health Comple
-
新田 浩之
富山医科薬科大学和漢薬研究所生物試験部門
-
新田 浩之
Division of Pharmacology, Research Institute for Wakan-Yaku (Oriental Medicines) Toyama Medical and
-
松本 欣三
Division of Pharmacology, Research Institute for Wakan-Yaku (Oriental Medicines) Toyama Medical and
-
清水 岑夫
Laboratory of Pharmacognosy, Department of Medicinal Resources, Faculty of Pharmaceutical Sciences T
-
倪 小虎
Division of Pharmacology, Research Institute for Wakan-Yaku (Oriental Medicines) Toyama Medical and
-
渡辺 裕司
Division of Pharmacology, Research Institute for Wakan-Yaku (Oriental Medicines) Toyama Medical and
-
清水 岑夫
Faculty Of Pharmaceutical Science Toyama Medical And Pharmaceutical University
-
清水 岑夫
富山医科薬科大学薬
-
清水 岑夫
富山大学薬学部
-
清水 岑夫
富山医科薬科大学和漢薬研究所
-
清水 岑夫
Faculty Of Pharmaceutical Science
-
松本 欣三
富山大学和漢医薬学総合研究所複合薬物薬理学
-
倪 小虎
Division Of Pharmacology Research Institute For Wakan-yaku (oriental Medicines) Toyama Medical And P
-
Ni Xiao-hu
Division Of Pharmacology Research Institute For Wakan-yaku (oriental Medicines)
-
Matsumoto Kinzo
Division Of Pharmacology Research Institute For Wakan-yaku (oriental Medicines)
-
Nitta Hiroyuki
Division Of Pharmacology Research Institute For Wakan-yaku (oriental Medicines)
-
渡辺 裕司
Division of Medicinal Pharmacology, Institute of Natural Medicine, University of Toyama
関連論文
- Studies on Aldose Reductase Inhibitors from Natural Products. IV. Constituents and Aldose Reductase Inhibitory Effect of Chrysanthemum morifolium, Bixa orellana and Ipomoea batatas
- Enhanced expression of BCL2/adenovirus EIB 19-kDa-interacting protein 3 mRNA, a candidate for intrinsic depression-related factor, and effects of imipramine in the frontal cortex of stressed mice
- P-35 一過性脳虚血誘発のマウス学習障害に対する釣藤鈎の作用
- MS-I-3 一過性脳虚血誘発のマウス学習障害に対する釣藤鈎の作用
- Effects of Manganese Complexes of Curcumin and Diacetylcurcumin on Kainic Acid-Induced Neurotoxic Responses in the Rat Hippocampus(Pharmacology)
- 日本茶の血糖降下作用成分に関する研究^
- Effects of Choto-san and Chotoko on thiopental-induced sleeping time
- 一過性虚血及び抗コリン薬スコポラミン誘発の学習障害に対する四物湯の改善作用及び処方解析
- スコポラミン誘発のマウス学習行動障害に対する四物湯及び構成生薬の影響 : 産婦・中枢神経系
- 生薬資源の生産と品質管理
- 茵〓蒿湯に含まれるβ-Glucuronidase阻害物質
- 5,7-ジヒドロキシ-4', 8-ジメトキシフラボンの合成 : CirsitakaogeninとCirsitakaosideの構造の訂正
- 5,7-ジヒドロキシ-4', 8-ジメトキシフラボンの合成 : CirsitakaogeninとCirsitakaosideの構造の訂正
- 5,7-ジヒドロキシ-4', 8-ジメトキシフラボンの合成 : CirsitakaogeninとCirsitakaosideの構造の訂正
- Panax ginseng Extract Improves the Scopolamine-Induced Disruption of 8-Arm Radial Maze Performance in Rats
- Panax ginseng Extract Improves the Performance of Aged Fischer 344 Rats in Radial Maze Task but Not in Operant Brightness Discrimination Task
- D-1 老齢ラットの学習行動障害に対する薬用人参の作用
- Corymine Potentiates NMDA-Induced Currents in Xenopus Oocytes Expressing NR1a/NR2B Glutamate Receptors
- P-01 補中益気湯長期間処置によるNG108-15細胞の遺伝子発現変化(脳神経・精神,一般演題ポスター,第24回和漢医薬学会大会 和漢薬の複雑さ-経験知と科学知-)
- The mRNA Expression Differences of RNA Editing Enzymes in Differentiated and Undifferentiated NG108-15 Cells
- Effects of Choto-san and Its Related Constituents on Endogenous Antioxidant Systems(Pharmacology)
- Antioxidant and Free Radical-Scavenging Activity of Choto-san and Its Related Constituents(Pharmacology)
- Chronic Treatment With Imipramine Inhibits Cell Growth and Enhances Serotonin 2C Receptor mRNA Expression in NG 108-15 Cells
- II-B-2 薬用人参 Ginseng Radix の神経細胞活性化物質と farcarinol について
- Studies on Aldose Reductase Inhibitors from Natural Products. V. Active Components of Hachimi-jio-gan (Kampo Medicine)
- I-C-13 薬用人参脂溶性エキス中の神経突起誘導作用物質について
- Evaluation of Angelicae Radix (Touki) by the Inhibitory Effect on Platelet Aggregation
- Studies on Aldose Reductase Inhibitors from Medicinal Plant of "Sinfito, " Potentilla candicans, and Further Synthesis of Their Related Compounds
- Radiation response mechanisms of the extremely radioresistant bacterium Deinococcus radiodurans
- 脳血管性認知症病態モデルにおける漢方薬「釣藤散」の薬理作用とその機序
- 複合薬物薬理学分野(病態制御部門,各部門・附属センターの活動と業績)
- 複合薬物薬理学分野(病態制御部門,各部門・附属センターの活動と業績)
- 生物試験分野(各部門・附属センターの活動と業績)
- 自然発症高血圧ラットにおける釣藤散の抗高血圧作用 : 釣藤鈎及び石膏の役割について
- P-29 釣藤鈎フェノール分画及び成分の降圧, 脳虚血予防作用
- 生物試験部門
- 釣藤散,釣藤鈎及びそのアルカロイド成分の脳虚血予防作用 : マウス水迷路学習行動を指標として
- P-6 自然発症高血圧ラットの血圧に対する釣藤鈎メタノールエキスおよびそのフェノール成分の作用
- P-5 自然発症高血圧ラットにおける釣藤散の降圧作用
- P-13 両側総頸動脈永久結紮ラットの学習行動に対する薬用人参及びタクリンの影響
- Anti-inflammatory Constituents of Topically Applied Crude Drugs. V. Constituents and Anti-inflammatory Effect of Aoki, Aucuba japonica THUNB.
- [総合ディスカッション] (現代社会のストレスと漢方の役割)
- 現代社会のストレスと漢方の役割
- 漢方薬の効果発現と臨床応用
- Inhibitory Effects of Corymine-Related Compounds on Glycine Receptors Expressed in Xenopus Oocytes
- タイ薬用植物成分 mitragynine の抗侵害受容作用に関与するオピオイド受容体サブタイプ
- Effects of Mitragynine on cAMP Formation Mediated by δ-Opiate Receptors in NG108-15 Cells
- Behavioral Studies on Alkaloids Extracted from the Leaves of Hunteria zeylanica
- Inhibitory Effect of Alkaloids Extracted from the Stem Bark of Hunteria zeylanica on 5-Lipoxygenase Activity in Vitro
- Effects of Alkaloids Extracted from the Stem Bark of Hunteria zeylanica on Acute Inflammation in Experimental Animals
- Heavy-Ion Microbeam System at JAEA-Takasaki for Microbeam Biology
- II-B-6 前脳基底核破壊ラットの明暗弁別学習障害に対する paeoniflorin の作用
- Permanent Occlusion of Bilateral Internal Carotid Arteries Produces Cognitive Deficits in Two Learning Behavior Tasks
- Tetramethylpyrazine Improves Spatial Cognitive Impairment Induced by Permanent Occlusion of Bilateral Common Carotid Arteries or Scopolamine in Rats
- Chotosan Enhances Macrophage Colony-Stimulating Factor mRNA Expression in the Ischemic Rat Brain and C6Bu-1 Glioma Cells(Biochemistry)
- Chotosan, a Kampo Formula, Ameliorates Chronic Cerebral Hypoperfusion-Induced Deficits in Object Recognition Behaviors and Central Cholinergic Systems in Mice
- Preventive Effect of Chotosan, a Kampo Medicine, on Transient Ischemia-Induced Learning Deficit Is Mediated by Stimulation of Muscarinic M_1 But Not Nicotinic Receptor(Pharmacology)
- Social Isolation Stress-Induced Oxidative Damage in Mouse Brain and Its Modulation by Majonoside-R2, a Vietnamese Ginseng Saponin(Pharmacology)
- The Effects of Choto-san on the mRNA Expression of Alzheimer's Disease Related Factors in the Permanent Ischemic Rat Brain(Pharmacology)
- 脳虚血誘発のマウス空間認知障害に対する釣藤散の効果 (第15回天然薬物の開発と応用シンポジウム講演要旨集) -- (一般講演)
- Expression Changes of the mRNA of Alzheimer's Disease Related Factors in the Permanent Ischemic Rat Brain(Pharmacology)
- DNA array analysis of gene expression changes by Choto-san in the ischemic rat brain
- Evaluation of the Nitric Oxide Radical Scavenging Activity of Manganese Complexes of Curcumin and Its Derivative(Pharmacology)
- Cytoprotective and Cytotoxic Effects of Curcumin : Dual Action on H_2O_2-Induced Oxidative Cell Damage in NG108-15 Cells
- Protective effect of Choto-san and its related constituents on hydrogen peroxide-induced cell damage in NG108-15 cells
- Ameliorative Effects of Paeoniflorin, a Major Constituent of Peony Root, on Adenosine A_1 Receptor-Mediated Impairment of Passive Avoidance Performance and Long-Term Potentiation in the Hippocampus
- Paeoniflorin, a Major Constituent of Peony Root, Reverses Muscarinic M_1-Receptor Antagonist-Induced Suppression of Long-Term Potentiation in the Rat Hippocampal Slice
- Diazepam binding inhibitor (DBI) gene expression in the brains of socially isolated and group-housed mice
- GTS-21, a Nicotinic Agonist, Attenuates Multiple Infarctions and Cognitive Deficit Caused by Permanent Occlusion of Bilateral Common Carotid Arteries in Rats
- Chronic Cerebral Hypoperfusion-Induced Neuropathological Changes in Rats
- Tacrine Improves Working Memory Deficit Caused by Permanent Occlusion of Bilateral Common Carotid Arteries in Rats
- Effect of Pilocarpine on Striatal Acetylcholine Release in Dopamine-Depleted Rats
- In Vitro Antioxidant Activity of Vietnamese Ginseng Saponin and Its Components
- The Possible Involvement of GABA_A Systems in the Antinarcotic Effect of Majonoside-R2, a Major Constituent of Vietnamese Ginseng, in Mice
- P-64 Type II コラーゲン誘導性関節炎に対する「補中益気湯」の有効性と免疫調節作用の検討
- P-19 長期隔離飼育マウスのペントバルビタール誘発睡眠と闘争行動に対する四物湯及びその構成生薬の作用
- 慢性脳循環障害モデルとしての両側総頸動脈永久結紮ラットの有用性
- The mRNA Expression of Serotonin 2C Subtype Receptors Uncoupled With Inositol Hydrolysis in NG108-15 Cells
- 29G-03 抗コリン薬 scopolamine によるラット海馬長期増強現象の抑制とそれに対する芍薬成分 paeoniflorin の効果
- 2'-Hydroxymatteucinol, a New C-Methyl Flavanone Derivative from Matteccia orientalis; Potent Hypoglycemic Activity in Streptozotocin (STZ)-Induced Diabetic Rat
- P-41 マウス肝及び脳ホモジェネートの脂質過酸化反応に対するベトナム人参サポニン画分及びその成分の影響
- Two New 2-Arylbenzofuran Derivatives from Hypoglycemic Activity-Bearing Fractions of Morus insignis
- 心理的ストレス負荷マウスにおける脳内脂質過酸化反応 : 一酸化窒素の関与及びGABA_A-ベンゾジアゼピン受容体系による修飾
- P-20 白血球及びマクロファージの貪食活性に及ぼすベトナム人参の影響
- P-18 慢性脳虚血ラットの学習行動障害に対する四物湯の影響
- II-A-9 ラットのスコポラミン誘発性空間認知障害に対する芍薬中のペオニフロリン関連成分の作用
- Antinociceptive and Antipyretic Effects of Alkaloids Extracted from the Stem Bark of Hunteria zeylanica
- P-8 芍薬成分 paeoniflorin の中枢作用に関する実験薬理学的研究
- Facilitatory and Inhibitory Effects of Harmaline on the Tryptophan- Induced 5-Hydroxytryptamine Syndrome and Body Temperature Changes in Pargyline-Pretreated Rats
- II-A-7 芍薬配糖体分画のスコポラミン誘発性空間認知障害に対する改善作用
- P-7 芍薬成分 paeoniflorin の記憶学習障害に対する改善作用
- I-A-19 前脳基底核破壊ラットの放射状迷路学習障害に対する芍薬成分 paeoniflorin の改善効果
- I-A-18 タイ民族薬 Randia siamensis Craib エキスの中枢作用
- P-10 総頚動脈永久結紮ラットの空間認知障害に対する Tetramethylpyrazine の改善作用
- 培養神経細胞の生存維持および神経膠細胞の増殖におよぼす薬用人参脂溶性画分の影響
- II-A-1 薬用人参の神経細胞生存維持効果
- A Comparative Study on the Effects of Nicotine and GTS : 21, a New Nicotinic Agonist, on the Locomotor Activity and Brain Monoamine Level
- Protective Effect of GTS-21, a Novel Nicotinic Receptor Agonist, on Delayed Neuronal Death Induced by Ischemia in Gerbils
- GTS-21, a Nicotinic Agonist, Protects against Neocortical Neuronal Cell Loss Induced by the Nucleus Basalis Magnocellularis Lesion in Rats
- 生薬の薬理学的評価:各種の学習行動障害モデルラットに対する四物湯及び構成生薬の作用 (〔第47回日本東洋医学会総会〕学会シンポジウム) -- (生薬資源の生産と品質管理)