Induction of Right Ventricular Hypertrophy in Neonatal Guinea Pigs by Monocrotaline
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概要
- 論文の詳細を見る
The purpose of this study was to develop an experimental model of neonatal right ventricular hypertrophy which was similar to human congenital heart disease associated with pulmonary hypertension. Monocrotaline (200 mg/kg), a pyrrolizidine alkaloid, was injected into neonatal Hartley guinea pigs on the day of delivery. The occurrence of pulmonary hypertension and right ventricular hypertrophy was confirmed by pressure studies and a determination of the right ventricular wet weight and myocyte diameter on the seventh day after delivery. Right ventricular systolic pressure was significantly increased at 7 days after monocrotaline treatment compared with the untreated control group. The ratio of right ventricular systolic pressure to left ventricular systolic pressure, an indicator of pulmonary hypertension, was significantly elevated from 0.32±0.02 in the controls to 0.59±0.03 in the monocrotaline group. Right ventricular wet weight was also significantly increased, indicating right ventricular hypertrophy. The diameter of cardiac myocytes was significantly increased in the right ventricle, and was decreased in the left ventricle and interventricular septum in the monocrotaline group. Neonatal guinea pigs developed pulmonary hypertension and marked right ventricular hypertrophy within 1 week after treatment with monocrotaline. This simple experimental model may have features similar to those of human congenital heart disease associated with pulmonary hypertension.
- 社団法人日本循環器学会の論文
- 1996-07-20
著者
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Eguchi S
Department Of Thoracic And Cardiovascular Surgery Niigata University School Of Medicine
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Watanabe Hiroshi
Department of Cardiology, Niigata City General Hospital
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EGUCHI SHOJI
Niigata University School of Medicine
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EGUCHI SHOJI
The 2nd Dep. of Surgery
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Tatebe Shoh
Department of Thoracic and Cardiovascular Surgery, Niigata University School of Medicine
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Miyamura Haruo
Department of Thoracic and Cardiovascular Surgery, Niigata University School of Medicine
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Sugawara Masa-aki
Department of Thoracic and Cardiovascular Surgery, Niigata University School of Medicine
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Eguchi Shoji
Department of Thoracic and Cardiovascular Surgery, Niigata University School of Medicine
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Miyamura Haruo
The Second Department of Surgery Niigata University School of Medicine
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Miyamura Haruo
Department Of Thoracic And Cardiovascular Surgery Niigata University School Of Medicine
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Eguchi Shoji
Department Of Cardiovascular Surgery Niigata Kobari Hospital
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Eguchi Shoji
The Second Department Of Surgery Of Niigata School Of Medicine
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Eguchi Shoji
Dept Of Thoracic And Cardiovascular Surgery Niigata University Hospital
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Eguchi Shoji
Second Department Of Surgery Niigata University School Of Medicine
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Tatebe Shoh
Department Of Thoracic And Cardiovascular Surgery Mito Saiseikai General Hospital
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Eguchi Shoji
Department Of Molecular Design And Engineering Nagoya University
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Sugawara Masa-aki
Department Of Thoracic And Cardiovascular Surgery Niigata University School Of Medicine
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Eguchi Shoji
The 2nd Department Of Surgery Niigata University School Of Medicine
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Sugawara Masaaki
Department Of Thoracic And Cardiovascular Surgery Niigata University School Of Medicine
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Watanabe Hiroshi
Division Of Thoracic And Cardiovascular Surgery Niigata University Graduate School Of Medical And De
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Watanabe Hiroshi
Department Of Applied Chemistry And Bioengineering Graduate School Of Engineering Osaka City Univers
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Eguchi Shoji
Department of Applied Chemistry Faculty of Engineering Nagoya University
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