DOES RECOMBINANT HUMAN ERYTHROPOIETIN ACCELERATE ERYTHROPOIESIS FOR PREDONATION BEFORE CARDIAC SURGERY?
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概要
- 論文の詳細を見る
This study was performed to determine the effect of recombinant human erythropoietin (rEPO) on preoperative autologous blood donation in patients undergoing elective coronary bypass or valvular operations. Nineteen patients received 200 u/kg of rEPO intravenously 3 times a week, and 210 mg/day of iron sulfate orally, for 2 weeks before surgery (EPO group). Seven matched patients only took the same dose of iron sulfate (control group). Bone marrow was aspirated from the sternum during surgery, and the Myeloids/Erythroids ratio was calculated in 13 patients of the EPO group. The total donated blood mass was 853±231 g in the EPO group, and 657±140 g in the control group (p<0.05). The average increase in hemoglobin (Hb) mass from admission to the day before surgery was 87±33 g in the EPO group, and 24±13 g in the control group (p<0.001). Furthermore, the logarithm of the ratio of "increased Hb mass / Hb mass at admission" was significantly correlated to the Myeloids / Erythroids ratio (r= -0.9130, p<0.01). These results strongly indicate that rEPO is a very useful agent for predonation of autologous blood for cardiac operations.
- 社団法人日本循環器学会の論文
- 1993-06-20
著者
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Eguchi S
Department Of Thoracic And Cardiovascular Surgery Niigata University School Of Medicine
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EGUCHI SHOJI
Niigata University School of Medicine
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Nakazawa Satoshi
The Second Department Of Surgery Niigata University School Of Medicine
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EGUCHI SHOJI
The 2nd Dep. of Surgery
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SHINONAGA MAYUMI
Second Department of Surgery, Niigata University School of Medicine
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Miyamura Haruo
Department of Thoracic and Cardiovascular Surgery, Niigata University School of Medicine
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Hayashi Jun-ichi
The Second Department of Surgery Niigata University School of Medicine
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Miyamura Haruo
The Second Department of Surgery Niigata University School of Medicine
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Eguchi Shoji
The Second Department of Surgery Niigata University School of Medicine
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HAYASHI JUN_ICHI
The Second Department of Surgery, Niigata University School of Medicine
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SHINONAGA MAYUMI
The Second Department of Surgery, Niigata University School of Medicine
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SHINADA SHOJI
The Second Department of Surgery, Niigata University School of Medicine
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Eguchi S
Department Of Molecular Design And Engineering Nagoya University
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Hayashi Junichi
The Department Of Thoracic And Cardiovascular Surgery Niigata University School Of Medicine
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Eguchi Shoji
The Second Department Of Surgery Of Niigata School Of Medicine
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Eguchi Shoji
Dept Of Thoracic And Cardiovascular Surgery Niigata University Hospital
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Eguchi Shoji
Second Department Of Surgery Niigata University School Of Medicine
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Shinada Shoji
The Second Department Of Surgery Niigata University School Of Medicine:the Blood Transfusion Divisio
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Hayashi Jun-ichi
The Second Department Of Surgery University Of Niigata Faculty Of Medicine
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Eguchi Shoji
The Second Department Of Surgery Niigata University
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Eguchi Shoji
Department Of Molecular Design And Engineering Nagoya University
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Eguchi Shoji
The 2nd Department Of Surgery Niigata University School Of Medicine
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Hayashi Jun-ichi
Division Of Thoracic And Cardiovascular Surgery Niigata University Graduate School Of Medical And De
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Hayashi Jun-ichi
Division Of Thoracic And Cardiovascular Surgery Niigata University Graduate School Of Medical And De
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Hayashi Jun-ichi
Division Of Cardiovascular And Thoracic Surgery Department Of Cardiovascular And Vital Control Gradu
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Hayashi Junichi
Department Of Thoracic And Cardiovascular Surgery Niigata University Graduate School Of Medical And
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Shinonaga Mayumi
Second Department Of Surgery Niigata University School Of Medicine
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EGUCHI Shoji
Department of Molecular Design and Engineering, Nagoya University
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