Analysis of the Effect of Surgical Lung Biopsy on Serum KL-6 Levels in Patients with Interstitial Pneumonia: Surgical Lung Biopsy Does not Elevate Serum KL-6 Levels
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概要
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Objective: It is well known that the serum level of KL-6 can be an indicator of disease activity in patients with interstitial pneumonia (IP). However, surgical lung biopsy is often required for the diagnosis of IP, although this can result in IP exacerbation. Methods: The effect of surgical lung biopsy on the serum level of KL-6 in patients with IP was analyzed. Thirty-two cases of IP were examined in this study. There were no cases showing exacerbation of IP. Results: The serum level of KL-6 demonstrated 1067±550 U/ml (mean±SD) before lung biopsy, 991±471 U/ml a day, 824±377 U/ml 4 days and 826±384 U/ml 7 days after lung biopsy. The serum KL-6 levels on the 1st, 4th, 7th day after the lung biopsy were significantly lower than that before the lung biopsy (P<0.05, P<0.01 and P<0.01, respectively). The percent decrease of the serum KL-6 levels on the 4th day (the lowest level) was dependent on the urine volume, and the analysis of the urinary levels of KL-6 showed a transient increase in urinary KL-6 excretion, suggesting that the decrease in serum KL-6 levels associated with surgical lung biopsy may be caused by this increase in urinary KL-6 excretion. Conclusion: Surgical lung biopsy of patients with IP has little effect on the increase in serum KL-6 levels. An elevation of serum KL-6 after surgical lung biopsy may indicate exacerbation of IP.
- 社団法人 日本内科学会の論文
著者
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HASEGAWA Takashi
Department of General Medicine, Niigata University Medical and Dental Hospital
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GEJYO Fumitake
Division of Respiratory Medicine, Niigata University Graduate School of Medical and Dental Sciences
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SUZUKI Eiichi
Department of General Medicine, Niigata University Medical and Dental Hospital
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NARITA Ichiei
Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and
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Narita Ichiei
新潟大学 大学院医歯学総合研究科腎・膠原病内科学
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TAKADA Toshinori
Division of Respiratory Medicine, Department of Homeostatic Regulation and Development, Course in Bi
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TSUKADA Hiroki
Division of Clinical Infection Control and Prevention, Niigata University Graduate School of Medical
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Narita Jun-ichi
Division of Respiratory Medicine, Niigata University Graduate School of Medical and Dental Sciences
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Tsuchida Masanori
Division of Thoracic and Cardiovascular Surgery, Niigata University Graduate School of Medical and D
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Terada Masaki
Division of Respiratory Medicine, Niigata University Graduate School of Medical and Dental Sciences
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Hashimoto Takehisa
Division of Thoracic and Cardiovascular Surgery, Niigata University Graduate School of Medical and D
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Aoki Tadashi
Division of Thoracic and Cardiovascular Surgery, Niigata University Graduate School of Medical and D
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Hayashi Jun-ichi
Division of Thoracic and Cardiovascular Surgery, Niigata University Graduate School of Medical and D
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Tsukada Hiroki
Division Of Clinical Infection Control And Prevention Niigata University Graduate School Of Medical
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Terada Masaki
Division Of Respiratory Medicine Graduate School Of Medical And Dental Sciences Niigata University
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Narita Ichiei
Division Of Clinical Nephrology And Intensive Care Medicine Niigata University Graduate School Of Me
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Takada Toshinori
Division Of Respiratory Medicine Department Of Homeostatic Regulation And Development Course In Biol
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Tsuchida Masanori
Division Of Thoracic And Cardiovascular Surgery Niigata University Graduate School Of Medical And De
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Hashimoto Takehisa
Division Of Thoracic And Cardiovascular Surgery Niigata University Graduate School Of Medical And De
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Narita Jun-ichi
Division Of Respiratory Medicine Graduate School Of Medical And Dental Sciences Niigata University
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Gejyo Fumitake
Division Of Clinical Infection Control And Prevention Niigata University Graduate School Of Medical
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Hayashi Jun-ichi
Division Of Cardiovascular And Thoracic Surgery Department Of Cardiovascular And Vital Control Gradu
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Aoki Tadashi
Division Of Chest Surgery Niigata Cancer Center Hospital
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Hasegawa Takashi
Department Of Biology Division Of Natural Science International Christian University
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Suzuki Eiichi
Department Of Applied Chemistry Tokyo Institute Of Technology
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NARITA Ichiei
Division of Respiratory Medicine, Niigata University Graduate School of Medical and Dental Sciences
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HASHIMOTO Takehisa
Division of Thoracic and Cardiovascular Surgery, Niigata University Graduate School of Medical and Dental Sciences
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Tsukada Hiroki
Division of Respiratory Medicine, Niigata University Graduate School of Medical and Dental Sciences
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