Decreased Levels of Circulating α2-Heremans-Schmid Glycoprotein/Fetuin-A (AHSG) in Patients with Rheumatoid Arthritis
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概要
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Objective Alpha2-Heremans Schmid glycoprotein/Fetuin-A (AHSG) is a circulating negative acute-phase protein, which inhibits bimineralization. It is often considered as a potential mediator between chronic inflammation and cardiovascular diseases. The metabolism of AHSG in patients with rheumatoid arthritis (RA) is unknown. Methods Serum AHSG concentrations were measured in 102 patients with RA using a newly developed indirect enzyme-linked immunosorbent assay (ELISA). Results The serum AHSG levels in the RA patients were significantly lower than that in healthy volunteers (249.8 ± 84.1 vs 425.0 ± 93.0 μg/ml, P<0.0001). Serum C-reactive protein concentration and erythrocyte sedimentation rate were inversely correlated, while albumin, hemoglobin and total cholesterol were positively correlated with AHSG. Current serum AHSG levels did not affect the presence of aortic calcification, whereas cumulative glucocorticoid dosage was significantly related to aortic calcification (P=0.005). Conclusion Serum AHSG levels were significantly decreased in patients with RA. The levels reflected inflammatory and malnutritional conditions. Its role in the development of cardiovascular diseases or inflammatory bone resorption remain uncertain in RA patients.
- 社団法人 日本内科学会の論文
著者
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GEJYO Fumitake
Division of Respiratory Medicine, Niigata University Graduate School of Medical and Dental Sciences
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NARITA Ichiei
Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and
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Narita Ichiei
新潟大学 大学院医歯学総合研究科腎･膠原病内科学
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SATO Hiroe
Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and
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KAZAMA Junichiro
Division of Nephrology and Intensive Care Medicine, Niigata University Medical and Dental Hospital
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KURODA Takeshi
Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and
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Wada Yoko
Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and
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Gao Ping
Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and
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Yamashita Hiroyuki
Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and
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Kuroda Takeshi
Division Of Clinical Nephrology And Rheumatology Niigata University Graduate School Of Medical And D
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Wada Yoko
Division Of Clinical Nephrology And Rheumatology Niigata University Graduate School Of Medical And D
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Narita Ichiei
Division Of Clinical Nephrology And Intensive Care Medicine Niigata University Graduate School Of Me
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Sato Hiroe
Division Of Clinical Nephrology And Rheumatology Niigata University Graduate School Of Medical And D
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Gejyo Fumitake
Division Of Clinical Infection Control And Prevention Niigata University Graduate School Of Medical
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KAZAMA Junichiro
Division of Blood Purification Therapy, Niigata University Medical and Dental Hospital
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KURODA Takeshi
Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences
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Sato Hiroe
Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences
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