Regulatory Functioning T Cell Population Contributing to the Mediation of Endotoxin Tolerance

概要

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Endotoxin tolerance (ET) has been considered to develop mainly due to the hyporesponsiveness of monocytes and macrophages. Weexamined the role ofT cells in ET mice. T cells derived from ET mice showed a decreased level of interferon-γ (IFN-γ) production in comparison to those from the control mice when T cells were cocultured with peritoneal exudate cells (PEC) adherent cells from the controls or lipopolysaccharide (LPS)- injected ET mice. After anti-CD3 stimulation, IFN-γ induction by T cells derived from ET mice was significantly decreased in comparison to those from the control mice. On the other hand, interleukin-10 (IL-10) secretion by T cells derived from ET mice was higher than in those of the control mice. When T cells with a high CD62L expression (CD62Lhigh T cells) were co-cultured with PEC adherent cells, the secretion of IFN-γ tended to decrease more than when these were co-cultured with T cells with a low CD62L expression (CD62Llow T cells). Our data suggest that T cells expressing CD62Lhigh T cells in ET mice can play a suppressive role in antigen-presenting cells through their cytokine production.
新潟大学の論文